2015
DOI: 10.1523/jneurosci.1469-15.2015
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FGF Signaling Is Necessary for Neurogenesis in Young Mice and Sufficient to Reverse Its Decline in Old Mice

Abstract: The mechanisms regulating hippocampal neurogenesis remain poorly understood. Particularly unclear is the extent to which age-related declines in hippocampal neurogenesis are due to an innate decrease in precursor cell performance or to changes in the environment of these cells. Several extracellular signaling factors that regulate hippocampal neurogenesis have been identified. However, the role of one important family, FGFs, remains uncertain. Although a body of literature suggests that FGFs can promote the pr… Show more

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Cited by 85 publications
(70 citation statements)
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“…Kuhn et al (1996) were the first to report a gradual age-related decline in hippocampal neurogenesis in the rat DG. This age-related decline in levels of neurogenesis is now well described in both mice and rats (Heine et al, 2004;Kang and Hebert, 2015;Rao et al, 2006). The age-related decline in neurogenesis is also accompanied by an age-related decline in cognitive function (Bolognin et al, 2014).…”
Section: Adult Hippocampal Neurogenesis and Cognitive Functionmentioning
confidence: 88%
“…Kuhn et al (1996) were the first to report a gradual age-related decline in hippocampal neurogenesis in the rat DG. This age-related decline in levels of neurogenesis is now well described in both mice and rats (Heine et al, 2004;Kang and Hebert, 2015;Rao et al, 2006). The age-related decline in neurogenesis is also accompanied by an age-related decline in cognitive function (Bolognin et al, 2014).…”
Section: Adult Hippocampal Neurogenesis and Cognitive Functionmentioning
confidence: 88%
“…1 mice demonstrated that FGF signaling is required for maintaining SGZ stem cells and sufficient to induce neurogenesis. 30 Altogether, FGF signaling is important for neurogenesis from the earliest stages of development through control of adult neurogenesis.…”
Section: Introductionmentioning
confidence: 99%
“…In addition to neurotrophic factors (e.g., BDNF) and growth factors (e.g., IGF-II) (Chen et al, 2011; Finsterwald and Alberini, 2014; Tyler et al, 2002) (Fig. 1), the FGF signaling has recently emerged as a new key player in synaptic plasticity and memory (Bookout et al, 2013; Kang and Hebert, 2015; Owen et al, 2013; Turner et al, 2012; Wu et al, 2012). In mammals, the FGF family consists of 22 members, of which FGF1 is predominantly expressed in neurons (Elde et al, 1991).…”
Section: Fgf1b a Crtc1-creb Target Gene Required For Memory Consolidmentioning
confidence: 99%