FGF19 Promotes the Proliferation and Insulin Secretion from Human
Pancreatic β Cells Via the IRS1/GLUT4 Pathway
Ting Zeng,
Xi Tang,
Xiaosu Bai
et al.
Abstract:Background Type 2 diabetes mellitus (T2DM) is a commonly observed
complication associated with obesity. The effect of fibroblast growth factor 19
(FGF19), a promising therapeutic agent for metabolic disorders, on pancreatic β
cells in obesity-associated T2DM remains poorly understood.
Methods Human pancreatic β cells were cultured with high glucose (HG) and
palmitic acid (PA), followed by treatment with FGF19. The cell pr… Show more
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