FGFR/Heartless and Smog interact synergistically to negatively regulate Fog mediated G-protein coupled receptor signaling in the <i>Drosophila</i> nervous system

Shweta, Kumari; Basargekar, Anagha; Ratnaparkhi, Anuradha

doi:10.1093/g3journal/jkaa029

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…The FGFR, Heartless (Htl), is expressed in glia and regulates glial morphogenesis (Stork et al, 2014). Htl was found to interact with Smog in a synergistic manner to suppress Fog signaling (Shweta et al, 2021).…”

Section: Regulation By G-protein-coupled Receptorsmentioning

confidence: 99%

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New developments in the biology of fibroblast growth factors

Ornitz

Itoh

2022

WIREs Mechanisms of Disease

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The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine kinases (FGFRs 1-4) and four intracellular proteins (intracellular FGFs or iFGFs) that primarily function to regulate the activity of voltagegated sodium channels and other molecules. The canonical FGFs, endocrine FGFs, and iFGFs have been reviewed extensively by us and others. In this review, we briefly summarize past reviews and then focus on new developments in the FGF field since our last review in 2015. Some of the highlights in the past 6 years include the use of optogenetic tools, viral vectors, and inducible transgenes to experimentally modulate FGF signaling, the clinical use of small molecule FGFR inhibitors, an expanded understanding of endocrine FGF signaling, functions for FGF signaling in stem cell pluripotency and differentiation, roles for FGF signaling in tissue homeostasis and regeneration, a continuing elaboration of mechanisms of FGF signaling in development, and an expanding appreciation of roles for FGF signaling in neuropsychiatric diseases.

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Section: Regulation By G-protein-coupled Receptorsmentioning

confidence: 99%

“…Fog elicits cell-shape change during gastrulation through the G-protein-coupled receptors Mist and Smog. FGFR (Htl) interacts synergistically with Smog to suppress Fog signaling (Shweta et al, 2021).…”

Section: Arthropod (Drosophila)mentioning

confidence: 99%

New developments in the biology of fibroblast growth factors

Ornitz

Itoh

2022

WIREs Mechanisms of Disease

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Embryonic spatiotemporal expression pattern of Folded gastrulation suggests roles in multiple morphogenetic events and regulation by AbdA

Katagade,

Kandroo,

Ratnaparkhi

2024

G3: Genes, Genomes, Genetics

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In Drosophila, the signaling pathway activated by the ligand Folded gastrulation (Fog) is amongst the few known G-protein coupled receptor (GPCR) pathways to regulate cell shape change with a well characterized role in gastrulation. However, an understanding of the spectrum of morphogenetic events regulated by Fog signaling is still lacking. Here, we present an analysis of the expression pattern and regulation of fog using a genome engineered Fog::sfGFP line. We show that Fog expression is widespread and in tissues previously not associated with the signaling pathway including germ cells, trachea and amnioserosa. In the CNS, we find that the ligand is expressed in multiple types of glia indicating a prominent role in the development of these cells. Consistent with this, we have identified three intronic enhancers whose expression in the CNS overlaps with Fog::sfGFP. Further, we show that enhancer-1, (fog intenh-1) located proximal to the coding exon is responsive to AbdA. Supporting this, we find that fog expression is downregulated in abdA mutants. Together, our study highlights the broad scope of Fog-GPCR signaling during embryogenesis and identifies Hox gene AbdA as a novel regulator of fog expression.

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The fly brain lands in Tokyo: A report on the 3rd Asia Pacific Drosophila Neurobiology Conference

Das,

Malak,

Sharma

et al. 2024

Genes to Cells

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The third Asia Pacific Drosophila Neurobiology Conference (APDNC3) was held in the Wako Campus of RIKEN in Tokyo, Japan, from February 27th to March 1st, 2024. While APDNC2 was held in Taiwan in 2019, the global coronavirus pandemic enforced a long hiatus. Hence, APDNC3 was a much‐anticipated meeting that attracted ~218 scientists from 18 different countries and regions, 154 from outside Japan. The meeting was divided into 13 scientific, 2 poster, and 3 career development sessions. Two plenary talks were delivered by Professor Daisuke Yamamoto, from NICT and Professor Claude Desplan from NYU. Thirty‐seven other speakers were invited to give lectures. Eighty‐six poster presenters were selected from submitted abstracts. Talks and posters described how neuronal circuits underlying specific behaviors were identified and how they developed. The presented work also demonstrated circuit‐specific cellular and molecular mechanisms in health and disease. It was clear that technological advances, like molecular genetic tools for identifying, manipulating, and imaging individual neurons and the great granularity of the fly brain connectome, were significantly augmenting research. Overall, the meeting highlighted the remarkable biological insights that fly neurobiologists continue to provide.

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FGFR/Heartless and Smog interact synergistically to negatively regulate Fog mediated G-protein coupled receptor signaling in the Drosophila nervous system

Cited by 3 publications

References 29 publications

New developments in the biology of fibroblast growth factors

New developments in the biology of fibroblast growth factors

Embryonic spatiotemporal expression pattern of Folded gastrulation suggests roles in multiple morphogenetic events and regulation by AbdA

The fly brain lands in Tokyo: A report on the 3rd Asia Pacific Drosophila Neurobiology Conference

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