FGFR3 and FGFR4 overexpression in juvenile nasopharyngeal angiofibroma: impact of smoking history and implications for personalized management

Safhi, Fatmah Ahmed; Al-Hazani, Tahani Mohamed Ibrahim; Jalal, Areej Saud; Alduwish, Manal Abdullah; Alshaya, Dalal S.; Almufareh, Nawaf Abdulrahman; Domiaty, Dalia Mostafa; Alshehri, Eman; Al-Shamrani, Salha M.; Abboosh, Tahani Saeed; Alotaibi, Mashael Alhumaidi; Alwaili, Maha Abdulla; Al-Qahtani, Wedad Saeed

doi:10.1007/s13353-023-00780-w

J Appl Genetics

2023

DOI: 10.1007/s13353-023-00780-w

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FGFR3 and FGFR4 overexpression in juvenile nasopharyngeal angiofibroma: impact of smoking history and implications for personalized management

Fatmah Ahmed Safhi,

Tahani Mohamed Ibrahim Al-Hazani,

Areej Saud Jalal

et al.

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2024

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Integrated Molecular and Histological Insights for Targeted Therapies in Mesenchymal Sinonasal Tract Tumors

Hoch,

Knoedler,

Knoedler

et al. 2024

Curr Oncol Rep

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Purpose of Review This review aims to provide a comprehensive overview of mesenchymal sinonasal tract tumors (STTs), a distinct subset of STTs. Despite their rarity, mesenchymal STTs represent a unique clinical challenge, characterized by their rarity, often slow progression, and frequently subtle or overlooked symptoms. The complex anatomy of the sinonasal area, which includes critical structures such as the orbit, brain, and cranial nerves, further complicates surgical treatment options. This underscores an urgent need for more advanced and specialized therapeutic approaches. Recent Findings Advancements in molecular diagnostics, particularly in next-generation sequencing, have significantly enhanced our understanding of STTs. Consequently, the World Health Organization has updated its tumor classification to better reflect the distinct histological and molecular profiles of these tumors, as well as to categorize mesenchymal STTs with greater accuracy. The growing understanding of the molecular characteristics of mesenchymal STTs opens new possibilities for targeted therapeutic interventions, marking a significant shift in treatment paradigms. Summary This review article concentrates on mesenchymal STTs, specifically addressing sinonasal tract angiofibroma, sinonasal glomangiopericytoma, biphenotypic sinonasal sarcoma, and skull base chordoma. These entities are marked by unique histopathological and molecular features, which challenge conventional treatment approaches and simultaneously open avenues for novel targeted therapies. Our discussion is geared towards delineating the molecular underpinnings of mesenchymal STTs, with the objective of enhancing therapeutic strategies and addressing the existing shortcomings in the management of these intricate tumors.

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Integrated Molecular and Histological Insights for Targeted Therapies in Mesenchymal Sinonasal Tract Tumors

Hoch,

Knoedler,

Knoedler

et al. 2024

Curr Oncol Rep

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show abstract

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FGFR3 and FGFR4 overexpression in juvenile nasopharyngeal angiofibroma: impact of smoking history and implications for personalized management

Cited by 1 publication

References 49 publications

Integrated Molecular and Histological Insights for Targeted Therapies in Mesenchymal Sinonasal Tract Tumors

Integrated Molecular and Histological Insights for Targeted Therapies in Mesenchymal Sinonasal Tract Tumors

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