FGFR4 Gly388Arg Polymorphism Reveals a Poor Prognosis, Especially in Asian Cancer Patients: A Meta-Analysis

Kim, Jung Han; Jeong, Seri; Jang, Hyun Joo; Park, Sung Taek; Kim, Hyeong Su

doi:10.3389/fonc.2021.762528

Cited by 6 publications

(2 citation statements)

References 72 publications

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“…In our case, the molecular-genetic analysis of the tumor showed controversial data: stable MSS status and low tumor mutation burden, but positive PD-L1 IHC and qPCR, overexpression of PD-1, TIGIT, CTLA4, IDO1, and LAG3 were identified. Using next-generation sequencing, FGFR p.G388R was found, and this variant was earlier identified in cancer patients with a high risk of recurrence and poor outcome [ 33 , 34 ]. In addition, expression analysis showed the progression phenotype of this tumor: adenosine A2b receptor was found to be a driver of progression in oral SCC cancer, and TGF-beta can undergo a conversion from tumor suppressor to tumor promoter in squamous cell cancer [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

HER2-Positive Lacrimal Sac Squamous Cell Carcinoma in a 57-Year-Old Man

Grachev,

Rabaev,

Avdalyan

et al. 2024

Case Rep Oncol

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Introduction: Lacrimal sac squamous cell carcinoma (SCC) is a rare tumor. Only 241 cases of lacrimal sac SCC have been reported in the literature. However, the detailed molecular profile of this tumor is unknown. Case Presentation: Fifty-seven-year-old Caucasian male presented with a 6-month history of epiphora. Multimodal examination revealed a unilateral lacrimal sac SCC T4aN0M0. The patient underwent primary surgery with subsequent chemoradiotherapy. The patient was alive 18 months after the end of the treatment, with no signs of local or distant relapse. Complex molecular profiling revealed the FGFR p.G388R variant, HER2 amplification, and progression phenotype. Conclusion: Here, we describe a clinical case of a male patient with lacrimal sac SCC with a careful description of the disease history, treatment, and molecular-genetic patterns of the tumor. This is the first report of HER2-positive lacrimal sac SCC.

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Section: Discussionmentioning

confidence: 99%

HER2-Positive Lacrimal Sac Squamous Cell Carcinoma in a 57-Year-Old Man

Grachev,

Rabaev,

Avdalyan

et al. 2024

Case Rep Oncol

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“…Loss of FGFR protein activity regulation is reported to be oncogenic leading to the overexpression of FGFR protein [ 32 ]. Another study has shown that the G388R in the protein kinase domain on FGFR4 has been proven to increase the potential of promoting cancer cells [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

In-Silico Analysis of Deleterious SNPs of FGF4 Gene and Their Impacts on Protein Structure, Function and Bladder Cancer Prognosis

Lim

Tan

et al. 2022

Life

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Dysregulation of fibroblast growth factors is linked to the pathogenesis of bladder cancer. The role of FGF1 and FGF3 is evident in bladder cancer; however, the role of FGF4 is vague. Despite being reported that FGF4 interacts with FGF1 and FGF3 in MAPK pathways, its pathogenesis and mechanism of action are yet to be elucidated. Therefore, this study aimed to elucidate pathogenic nsSNPs and their role in the prognosis of bladder cancer by employing in-silico analysis. The nsSNPs of FGF4 were retrieved from the NCBI database. Different in silico tools, PROVEAN, SIFT, PolyPhen-2, SNPs&GO, and PhD-SNP, were used for predicting the pathogenicity of the nsSNPs. Twenty-seven nsSNPs were identified as “damaging”, and further stability analysis using I-Mutant 2.0 and MUPro indicated 22 nsSNPs to cause decreased stability (DDG scores < −0.5). Conservation analysis predicted that Q97K, G106V, N164S, and N167S were highly conserved and exposed. Biophysical characterisation indicated these nsSNPs were not tolerated, and protein-protein interaction analysis showed their involvement in the GFR-MAPK signalling pathway. Furthermore, Kaplan Meier bioinformatics analyses indicated that the FGF4 gene deregulation affected the overall survival rate of patients with bladder cancer, leading to prognostic significance. Thus, based on these analyses, our study suggests that the reported nsSNPs of FGF4 may serve as potential targets for diagnoses and therapeutic interventions focusing on bladder cancer.

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Fast Claisen condensation reaction optimization in a continuous flow reactor

Michałek,

Powała,

Gurba-Bryśkiewicz

et al. 2023

Monatsh Chem

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In our previous study, we described the batch synthesis of CPL304110, an innovative pan-FGFR inhibitor. Herein, we transferred the Claisen condensation reaction, one of the synthesis steps to a continuous flow reactor. A simple solvent switch from ethanol to tetrahydrofuran shortened the original reaction time from 20 h to 10 min. With the use of the design of experiment method and program Statistica®, we optimized reaction parameters and increased the reaction yields from 73 to 84% with greatly shortened reaction times (20 h vs. 2 min), improved productivity (74.4 g h−1), and increased space–time yield (3720 kg h−1 m−3). Graphical abstract

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FGFR4 Gly388Arg Polymorphism Reveals a Poor Prognosis, Especially in Asian Cancer Patients: A Meta-Analysis

Cited by 6 publications

References 72 publications

HER2-Positive Lacrimal Sac Squamous Cell Carcinoma in a 57-Year-Old Man

HER2-Positive Lacrimal Sac Squamous Cell Carcinoma in a 57-Year-Old Man

In-Silico Analysis of Deleterious SNPs of FGF4 Gene and Their Impacts on Protein Structure, Function and Bladder Cancer Prognosis

Fast Claisen condensation reaction optimization in a continuous flow reactor

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