Fiber-based early diagnosis of venous thromboembolic disease by label-free D-dimer detection

Zubiate, Pablo; Urrutia, Aitor; Zamarreño, Carlos R.; Egea-Urra, Josune; Fernández‐Irigoyen, Joaquín; Giannetti, Ambra; Baldini, Francesco; Díaz, Silvia; Matı́as, Ignacio R.; Arregui, Francisco J.; Santamaría, Enrique; Chiavaioli, Francesco; Villar, Ignacio Del

doi:10.1016/j.biosx.2019.100026

Cited by 51 publications

(45 citation statements)

References 56 publications

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“…These results were due to the optical properties of the thin film, which were in agreement with the established theory that predicts that a LMR support coating with a high refractive index will lead to devices with high sensitivity to SRI variations [6]. Accordingly, several biosensors have been designed using tin oxide coatings as LMR support coatings, aiming to obtain the lowest possible limit of detection (LOD), as is the case D-dimer [34] and immunoglobulin G [29] sensors.…”

Section: Discussionsupporting

confidence: 82%

“…This improvement is a direct consequence of the higher sensitivity of tin oxide coating based refractometers. Additionally, a D-dimer sensor was studied in [34] using a tin-oxide-coated D-shaped fiber. This work presents LODs of 10 ng/mL and 100 ng/mL when tested in buffer and human serum, respectively, with response times of 10-20 min, which fit the range of other D-dimer detection platforms.…”

Section: Tin Oxidementioning

confidence: 99%

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A Comprehensive Review: Materials for the Fabrication of Optical Fiber Refractometers Based on Lossy Mode Resonance

Ozcáriz

Zamarreño

Arregui

2020

Sensors

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Lossy mode resonance based sensors have been extensively studied in recent years. The versatility of the lossy mode resonance phenomenon has led to the development of sensors based on different configurations that make use of a wide range of materials. The coating material is one of the key elements in the performance of a refractometer. This review paper intends to provide a global view of the wide range of coating materials available for the development of lossy mode resonance based refractometers.

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Section: Discussionsupporting

confidence: 82%

Section: Tin Oxidementioning

confidence: 99%

A Comprehensive Review: Materials for the Fabrication of Optical Fiber Refractometers Based on Lossy Mode Resonance

Ozcáriz

Zamarreño

Arregui

2020

Sensors

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“…Furthermore, taking into account its simplest configuration, robustness, etc., its transfer to the industry seems more straightforward than its fiber optic counterpart. For all this reasons, and in view of the results achieved already with optical fiber [25], it is a good platform for development of chemical and biological applications.…”

Section: Introductionmentioning

confidence: 99%

Generation of lossy mode resonances with different nanocoatings deposited on coverslips

Fuentes¹,

Goicoechea²,

Corres³

et al. 2020

Opt. Express

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The generation of lossy mode resonances (LMRs) with a setup based on lateral incidence of light in coverslips is a simple platform that can be used for sensing. Here the versatility of this platform is proved by studying the deposition of different coating materials. The devices were characterized with both SEM and AFM microscopy, as well as ellipsometry, which allowed obtaining the main parameters of the coatings (thickness, refractive index and extinction coefficient) and relating them with the different sensitivities to refractive index attained with each material. In this way it was possible to confirm and complete the basic rules observed with lossy mode resonance based optical fiber sensors towards the design of simpler and more compact applications in domains such as chemical sensors or biosensors.

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“…Another advantage that optical fiber offers is that silica surfaces can be easily modified in order to allow the deposition of different materials such as polymers [25], polyelectrolytes [26], or even biochemical species [27]. Furthermore, the properties of the deposited materials can be tailored in a nanometric scale [28], which enables the fabrication of custom-made sensors.…”

Section: Introductionmentioning

confidence: 99%

Development of an Aptamer Based Luminescent Optical Fiber Sensor for the Continuous Monitoring of Hg2+ in Aqueous Media

Elosúa

Arregui

2020

Sensors

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A fluorescent optical fiber sensor for the detection of mercury (Hg2+) ions in aqueous solutions is presented in this work. The sensor was based on a fluorophore-labeled thymine (T)-rich oligodeoxyribonucleotide (ON) sequence that was directly immobilized onto the tip of a tapered optical fiber. In the presence of mercury ions, the formation of T–Hg2+-T mismatches quenches the fluorescence emission by the labeled fluorophore, which enables the measurement of Hg2+ ions in aqueous solutions. Thus, in contrast to commonly designed sensors, neither a fluorescence quencher nor a complementary ON sequence is required. The sensor presented a response time of 24.8 seconds toward 5 × 10−12 M Hg2+. It also showed both good reversibility (higher than the 95.8%) and selectivity: the I0/I variation was 10 times higher for Hg2+ ions than for Mn2+ ions. Other contaminants examined (Co2+, Ag+, Cd2+, Ni2+, Ca2+, Pb2+, Mn2+, Zn2+, Fe3+, and Cu2+) presented an even lower interference. The limit of detection of the sensor was 4.73 × 10−13 M Hg2+ in buffer solution and 9.03 × 10−13 M Hg2+ in ultrapure water, and was also able to detect 5 × 10−12 M Hg2+ in tap water.

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Fiber-based early diagnosis of venous thromboembolic disease by label-free D-dimer detection

Cited by 51 publications

References 56 publications

A Comprehensive Review: Materials for the Fabrication of Optical Fiber Refractometers Based on Lossy Mode Resonance

A Comprehensive Review: Materials for the Fabrication of Optical Fiber Refractometers Based on Lossy Mode Resonance

Generation of lossy mode resonances with different nanocoatings deposited on coverslips

Development of an Aptamer Based Luminescent Optical Fiber Sensor for the Continuous Monitoring of Hg2+ in Aqueous Media

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