Fiber Bragg Grating Sensors-Based Thermometry of Gold Nanorod-Enhanced Photothermal Therapy in Tumor Model

Bianchi, L.; Mooney, Rachael; Cornejo, Yvonne R; Hyde, Caitlyn; Schena, Emiliano; Berlin, Jacob M.; Aboody, Karen S.; Saccomandi, Paola

doi:10.1109/jsen.2021.3082042

Cited by 27 publications

(14 citation statements)

References 48 publications

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“…Moreover, the complexity and invasiveness as well as the strict dependence of the overall result on the operator’s ability and experience restrain the applicability of this treatment approach 4 . Therefore, novel therapeutic strategies are emerging 5 – 7 . Among these, thermal ablation procedures demonstrated encouraging results 8 : they aim at reducing cancer tumor volume, to achieve better local disease control, with the final intent of improving survival and quality of life 9 .…”

Section: Introductionmentioning

confidence: 99%

Estimation of porcine pancreas optical properties in the 600–1100 nm wavelength range for light-based therapies

Lanka

Bianchi

Farina

et al. 2022

Sci Rep

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This work reports the optical properties of porcine pancreatic tissue in the broad wavelength range of 600–1100 nm. Absorption and reduced scattering coefficients (µa and µs′) of the ex vivo pancreas were obtained by means of Time-domain Diffuse Optical Spectroscopy. We have investigated different experimental conditions—including compression, repositioning, spatial sampling, temporal stability—the effect of the freezing procedure (fresh vs frozen-thawed pancreas), and finally inter-sample variability. Good repeatability under different experimental conditions was obtained (median coefficient of variation less than 8% and ~ 16% for µa and µs′, respectively). Freezing–thawing the samples caused an irreversible threefold reduction of µs′ and no effect on µa. The absorption and reduced scattering spectra averaged over different samples were in the range of 0.12–0.74 cm−1 and 12–21 cm−1 with an inter-sample variation of ~ 10% and ~ 40% for µa and µs′, respectively. The calculated effective transport coefficient (µeff) for fresh pancreatic tissue shows that regions between 800–900 nm and 1050–1100 nm are similar and offer the lowest tissue attenuation in the considered range (i.e., µeff ranging from 2.4 to 2.7 cm−1). These data, describing specific light-pancreas interactions in the therapeutic optical window for the first time, provide pivotal information for planning of light-based thermotherapies (e.g., laser ablation) and instruction of light transport models for biophotonic applications involving this organ.

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Section: Introductionmentioning

confidence: 99%

Estimation of porcine pancreas optical properties in the 600–1100 nm wavelength range for light-based therapies

Lanka

Bianchi

Farina

et al. 2022

Sci Rep

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“…Additionally, they provide multi-point temperature measurements using a small-sized optical fiber embedding multiple FBG sensors, thus enabling the reconstruction of the temperature profile with accuracy for each sensor of 0.1 °C. Additional details on FBG sensors are reported in the previous papers of our group [ 12 , 56 , 57 , 58 , 59 , 60 ].…”

Section: Methodsmentioning

confidence: 99%

Gold Nanoparticles-Mediated Photothermal Therapy of Pancreas Using GATE: A New Simulation Platform

Asadi

Bianchi

Landro

et al. 2022

Cancers

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This work presents the first investigation of gold nanorods (GNRs)-based photothermal therapy of the pancreas tumor using the Monte Carlo-based code implemented with Geant4 Application for Emission Tomography (GATE). The model of a human pancreas was obtained by segmenting an abdominal computed tomography (CT) scan, and its physical and chemical properties, were obtained from experimental and theoretical data. In GATE, GNRs-mediated hyperthermal therapy, simple heat diffusion as well as interstitial laser ablation were then modeled in the pancreas tumor by defining the optical parameters of this tissue when it is loaded with GNRs. Two different experimental setups on ex vivo pancreas tissue and GNRs-embedded water were devised to benchmark the developed Monte Carlo-based model for the hyperthermia in the pancreas alone and with GNRs, respectively. The influence of GNRs on heat distribution and temperature increase within the pancreas tumor was compared for two different power values (1.2 W and 2.1 W) when the tumor was exposed to 808 nm laser irradiation and with two different laser applicator diameters. Benchmark tests demonstrated the possibility of the accurate simulating of NPs-assisted thermal therapy and reproducing the experimental data with GATE software. Then, the output of the simulated GNR-mediated hyperthermia emphasized the importance of the precise evaluation of all of the parameters for optimizing the preplanning of cancer thermal therapy. Simulation results on temperature distribution in the pancreas tumor showed that the temperature enhancement caused by raising the power was increased with time in both the tumor with and without GNRs, but it was higher for the GNR-load tumor compared to tumor alone.

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“…Recently, Yasli theoretically designed a surface plasmon resonance (SPR)-based photonic crystal fiber biosensor for the detection of early-stage cancer, which exhibited a maximum sensitivity of 7142.86 nm/RIU . The advancements in optical fiber technology have renovated the sensing capabilities of optical fiber-based sensing devices − and enhanced their use for biomedical applications in the oncological domain. , These devices have plenty of advantageous features such as resistance to electromagnetic interference, light weight, remote sensing applications, easy designing, capability of wavelength multiplexing, multiparameter measurements, fast response time, and high sensitivity with a wide detection range. , Thus, by taking into consideration the several advantageous features accessible from optical fiber, the research area of fiber optic sensors is reached to a level where miniaturized low-cost devices are easily achievable for fast and consistent sensing applications. In this framework, prism/optical fiber-based sensors satisfy many of these valuable properties.…”

Section: Introductionmentioning

confidence: 99%

Antimonene-Coated Uniform-Waist Tapered Fiber Optic Surface Plasmon Resonance Biosensor for the Detection of Cancerous Cells: Design and Optimization

Vikas

Saccomandi

2023

ACS Omega

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For early-stage cancer detection, a novel design of graphene-antimonene-coated uniform-waist tapered fiber optic surface plasmon resonance (SPR) biosensor is demonstrated. The proposed optical biosensor outperforms over a wide range of refractive index (RI) variations including biological solutions and is designed to detect various cancerous cells in the human body whose RIs are in the range of 1.36–1.4. Here, antimonene is used to enhance the performance of the designed SPR sensor for sensing cancer analytes because of its high binding energy toward adsorption of biomolecules and large active surface area. The design and analysis of the sensor are done with the help of a transfer matrix method-based simulation platform, and the effect of the taper ratio is also studied. The performance of the proposed SPR biosensor is evaluated with performance parameters such as sensitivity, full width at half maximum, detection accuracy (DA), figure of merit (FOM), and limit of detection (LOD). The numerical results show that the designed sensor is able to provide a sensitivity of 7.3465, 10.9250, 11.8914, and 15.2414 μm/RIU, respectively, for sensing skin, cervical, blood, and adrenal gland cancer with a maximum FOM of 131.1525 RIU–1, DA of 14.2126 μm–1, and LOD of 7.2 × 10–5 RIU. Based on the derived results, the authors believe that the designed SPR sensor could practically find its potential applications in the field of medical science for the early-stage diagnosis of cancer and hence, opens a new window in the field of biosensing.

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Fiber Bragg Grating Sensors-Based Thermometry of Gold Nanorod-Enhanced Photothermal Therapy in Tumor Model

Cited by 27 publications

References 48 publications

Estimation of porcine pancreas optical properties in the 600–1100 nm wavelength range for light-based therapies

Estimation of porcine pancreas optical properties in the 600–1100 nm wavelength range for light-based therapies

Gold Nanoparticles-Mediated Photothermal Therapy of Pancreas Using GATE: A New Simulation Platform

Antimonene-Coated Uniform-Waist Tapered Fiber Optic Surface Plasmon Resonance Biosensor for the Detection of Cancerous Cells: Design and Optimization

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