Fiber-Optic Biosensor Technology for Rapid, Accurate and Specific Detection of Enzymes

Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVII

2017

Self Cite

We demonstrate a novel single point, multi-parameter, fiber optic sensor concept based on a combination of interferometric and plasmonic sensor modalities on an optical fiber end face. The sensor consists of a micro-Fabry-Perot interferometer in the form of a hemispherical stimuli-responsive hydrogel with immobilized gold nanoparticles. We present results of proof-of-concept experiments demonstrating local surface plasmon resonance (LSPR) sensing of refractive index (RI) in the visible range and interferometric measurements of volumetric changes of the pH stimuli-responsive hydrogel in near infrared range. The response of LSPR to RI ( ∆λr ∆RI ∼ 877nm/RI) and the free spectral range (FSR) to pH ( ∆pH ∆FSR = 0.09624/nm) were measured with LSPR relatively constant for hydrogel swelling degree and FSR relatively constant for RI. We expect this novel sensor concept to be of great value for biosensors for medical applications.

Section: Resultsmentioning

confidence: 99%

Section: Figure 5: Fsr Measurements As a Function Hydrogel Swelling Dmentioning

confidence: 99%

Section: Lspr and Fsr Measuements As A Function Of Bulk Rimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Interferometric and localized surface plasmon based fiber optic sensor

Muri

Bano

Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVII

2017

Self Cite

“…Fiber-optic biosensors based on interferometric measurement of dimensional change in stimuli-responsive hydrogels immobilized on an optical fiber end-face is an emerging sensor technology with many interesting applications in medicine [1,2]. We have used this technology for tissue PSA measurements [3] and glucose measurements [4,5].…”

Section: Introductionmentioning

confidence: 99%

Low-cost high performance readout system for fiber-optic biosensors

Strømstad

2015

SPIE Proceedings

We have developed an instrument for real time continuous interferometric measurement of dimensional change in stimuli-responsive hydrogel sensors. The instrument consists of a superfluorecent LED and a low-cost grating spectrometer. All signal conditioning and processing is performed using a microprocessor. We have tested the instrument with a glucose sensitive hydrogel sensor. The rms noise on the length measurement is less than 1.4 nm, whereas rms noise on the length change is less than 0.25 nm. An observed bias of the length measurement can be reduced by minor changes in the frequency estimation algorithm used.

A Single-Point, Multiparameter, Fiber Optic Sensor Based on a Combination of Interferometry and LSPR

Muri

Bano

2018

J. Lightwave Technol.

Self Cite

We demonstrate a new single point, multiparameter, fiber optic sensor concept based on a combination of interferometric and plasmonic sensor modalities on an optical fiber end face. The sensor consists of an extrinsic Fabry-Perot interferometer in the form of a hemispherical stimuli-responsive hydrogel with immobilized gold nanoparticles (GNPs). The GNPs exhibit local surface plasmon resonance (LSPR) that is sensitive towards the local refractive index (RI) of the surrounding environment, while the stimuli-responsive hydrogel is sensitive towards specific chemical compounds. We evaluate the quality of the interferometric and LSPR signals as function of GNP concentration and of hydrogel swelling degree stimulated by ethanol solutions. The GNPs have little influence on the visibility of the Fabry-Perot etalon. The swelling degree of the hydrogel, with corresponding bulk RI changes, have little influence on the local surface RI of the GNPs. We expect this novel sensor concept to be of great value for biosensors for medical applications.