Fiber-reinforced silicone for tracheobronchial stents: An experimental study

Vearick, Samanta Bianchi; Demétrio, Kétner Bendo; Xavier, Rogério Gastal; Moreschi, Alexandre Heitor; Müller, André Frotta; Sanches, Paulo Roberto Stefani; Santos, Luís Alberto Loureiro dos

doi:10.1016/j.jmbbm.2017.10.013

Cited by 13 publications

(8 citation statements)

References 17 publications

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“…However, the Natural stent did not present any tangible benefit over the Dumon stent for managing benign tracheobronchial stenosis patients. Given the limitations in terms of shape and mechanical features of the silicone, Vearick et al (23) tested the reinforcement of silicone using fibers, including polypropylene (PP), polyamide (PA) and carbon fiber (CF). Tensile strength and Shore A hardness testing showed that CF exhibited the best mechanical performance, and subsequent finite element compression strength tests further confirmed this result.…”

Section: Novel Silicone Stentsmentioning

confidence: 99%

A narrative review of progress in airway stents

Tian

Huang

et al. 2022

J Thorac Dis

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Background and Objective: Airway stents, used to restore airway patency, are mostly utilized by patients with malignant airway strictures, and are occasionally used in a range of other airway related diseases, including conditions which result in benign stenosis, malacia, and fistula. There has been an increasing number of airway stents that are being developed thanks to improvements in interventional therapy. However, the method of promoting airway stents for clinical application remains undetermined.Herein, we describe the recent advances in airway stents by reviewing the published studies, providing the reference for clinical decision-making and further research on airway stents.Methods: Relevant articles between January 1964 and November 2021 were obtained from PubMed, Web of Science, and EMBASE databases. The terms "metallic", "silicone", "drug-eluting", "biodegradable", "radioactive", "three-dimensional (3D)", and "stents" were searched in different combinations.

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Section: Novel Silicone Stentsmentioning

confidence: 99%

A narrative review of progress in airway stents

Tian

Huang

et al. 2022

J Thorac Dis

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“…[17] Nylon, the most common form of polyamide (PA) has good elasticity, fatigue resistance, and stability is widely used as suture materials and in dentures production. Because of the excellent biological stability and good elasticity, silicone is especially suitable for the usages as scaffolds, [18] for instance, as artificial implants used in laryngeal surgery and plastic surgery due to low infection risk. [19] Polyvinylidene fluoride (PVDF), polyimide, parylene, and polydimethylsiloxane (PDMS) have excellent chemical and thermal stability, even compatible with biological substances, extensively used as envelopes to protect implanted electronic devices from moisture and ions inside the human body.…”

Section: Bioinert Polymersmentioning

confidence: 99%

Emerging polymeric biomaterials and manufacturing techniques in regenerative medicine

et al. 2022

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The current demand for patients’ organ and tissue repair and regeneration is continually increasing, where autologous or allograft is the golden standard treatment in the clinic. However, due to the shortage of donors, mismatched size and modality, functional loss of the donor region, possible immune rejection, and so forth, the application of auto‐/allo‐grafts is frequently hindered in many cases. In order to solve these problems, artificial constructs structurally and functionally imitating the extracellular matrix have been developed as substitutes to promoting cell attachment, proliferation, and differentiation, and ultimately forming functional tissues or organs for better tissue regeneration. Particularly, polymeric materials have been widely utilized in regenerative medicine because of their ease of manufacturing, flexibility, biocompatibility, as well as good mechanical, chemical, and thermal properties. This review presents a comprehensive overview of a variety of polymeric materials, their fabrication methods as well applications in regenerative medicine. Finally, we discussed the future challenges and perspectives in the development and clinical transformation of polymeric biomaterials.

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“…64 Specific materials include PDS (n = 5), polycaprolactone (n = 3), poly(lactic-co-glycolic acid) (n = 4), poly-L-lactic acid (n = 5), poly(L-lactideco-ε-caprolactone) (n = 1), polyisoprene (n = 1), poly-Llactide-caprolactone (n = 1), poly(D,L-lactide-co-ε-caprolactone)s [poly(DLLA-co-CL)s] (n = 1), and Poly(D,Llactide) (n = 1) (Tables I and IV). 22,[53][54][55][56][57]59,[61][62][63][64][65][67][68][69][70][71][72][73][74][75][76][77] One study utilized a woven polymer stent without additional material details. 15 The animal models included leporine (n = 13), canine (n = 2), rats (n = 1), mouse (n = 1), and swine (n = 1).…”

Section: Polymer Stentsmentioning

confidence: 99%

State of the Science in Tracheal Stents: A Scoping Review

et al. 2021

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Objective: Recent material science advancements are driving tracheal stent innovation. We sought to assess the state of the science regarding materials and preclinical/clinical outcomes for tracheal stents in adults with benign tracheal disease.Methods: A comprehensive literature search in April 2021 identified 556 articles related to tracheal stents. One-hundred and twenty-eight full-text articles were reviewed and 58 were included in the final analysis. Datapoints examined were stent materials, clinical applications and outcomes, and preclinical findings, including emerging technologies.Results: In the 58 included studies, stent materials were metals (n = 28), polymers (n = 19), coated stents (n = 19), and drug-eluting (n = 5). Metals included nitinol, steel, magnesium alloys, and elgiloy. Studies utilized 10 different polymers, the most popular included polydioxanone, poly-L-lactic acid, poly(D,L-lactide-co-glycolide), and polycaprolactone. Coated stents employed a metal or polymer framework and were coated with polyurethane, silicone, polytetrafluoroethylene, or polyester, with some polymer coatings designed specifically for drug elution. Drug-eluting stents utilized mitomycin C, arsenic trioxide, paclitaxel, rapamycin, and doxycycline. Of the 58 studies, 18 were human and 40 were animal studies (leporine = 21, canine = 9, swine = 4, rat = 3, ovine/feline/murine = 1). Noted complications included granulation tissue and/or stenosis, stent migration, death, infection, and fragmentation.Conclusion: An increasing diversity of materials and coatings are employed for tracheal stents, growing more pronounced over the past decade. Though most studies are still preclinical, awareness of tracheal stent developments is important in contextualizing novel stent concepts and clinical trials.

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Fiber-reinforced silicone for tracheobronchial stents: An experimental study

Cited by 13 publications

References 17 publications

A narrative review of progress in airway stents

A narrative review of progress in airway stents

Emerging polymeric biomaterials and manufacturing techniques in regenerative medicine

State of the Science in Tracheal Stents: A Scoping Review

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