Fibersol-2 induces apoptosis of<i>Apc</i>-deficient colorectal Cancer (SW480) cells and decreases polyp formation in<i>Apc</i>MIN mice

Cuesta, Sara; Olson, Susan Losee; So, Eui Young; Shimomura, Kazuhiro; Ouchi, Toru; Preuss, Fabian

doi:10.1080/15384047.2016.1177685

Cited by 6 publications

(5 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Resistant maltodextrin (RM), a soluble dietary fiber classified as resistant starch type V, will not be absorbed in the small intestine because of its debranching structure [ 30 ]. A previous study has even indicated anticancer activity of resistant maltodextrin in vitro [ 18 ]. In the present study, we found that RM oral administration could alleviate the DAI score increase induced by DSS, improve the intestinal histology damage, and significantly suppress the proinflammatory cytokines through increasing faecal butyric acid.…”

Section: Discussionmentioning

confidence: 99%

“…Resistant maltodextrin (RM), a soluble dietary fiber [ 16 ] classified as resistant starch type V, is produced by debranching of the starch structure [ 17 ]. Fibersol-2 (a type of digest-resistant maltodextrin) showed anticancer activity in vitro [ 18 ] and is fermentable in the colon by colonic bacteria and produces short-chain fatty acid [ 17 ]. Fibersol-2 can also increase faecal Bifidobacterium populations and butyrate proportion [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Resistant Maltodextrin Alleviates Dextran Sulfate Sodium-Induced Intestinal Inflammatory Injury by Increasing Butyric Acid to Inhibit Proinflammatory Cytokine Levels

Wang

Zhang

Huang

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD), one kind of intestinal chronic inflammatory disease, is characterized by colonic epithelial barrier injury, overproduction of proinflammatory cytokines, and fewer short-chain fatty acids (SCFAs). The present study is aimed at testing the hypothesis that resistant maltodextrin (RM), a soluble dietary fiber produced by starch debranching, alleviated dextran sulfate sodium- (DSS-) induced colitis in mice. Female C57BL/6 mice with or without oral administration of 50 mg/kg RM for 19 days were challenged with 3% DSS in drinking water to induce colitis (from day 14 to day 19). Although RM could not reverse DSS-induced weight loss or colon shortening, it reduced inflammatory cell infiltration and epithelial damage in colon tissue, as well as the transfer of intestinal permeability indicators including serum diamine oxidase (DAO) and D-lactic acid (D-LA). ELISA analysis indicated that RM significantly suppressed the increase of Th1 cytokines induced by DSS in the colon such as tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). The levels of proinflammatory cytokines interleukin-1β (IL-1β), IL-17, and IL-8 in the DSS group were significantly higher than those in the control group and RM group, but no significant difference was observed in the RM-DSS group compared with the RM group. Interestingly, IL-10 levels of the DSS group were significantly higher than those of the other groups. With respect to SCFAs, DSS administration significantly decreased the concentration of faecal butyric acid while the RM-DSS group showed a tendency to increase (P=0.08). In general, RM alleviated dextran sulfate sodium-induced intestinal inflammation through increasing the level of butyric acid and subsequently inhibiting the expression of proinflammatory cytokines.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Resistant Maltodextrin Alleviates Dextran Sulfate Sodium-Induced Intestinal Inflammatory Injury by Increasing Butyric Acid to Inhibit Proinflammatory Cytokine Levels

Wang

Zhang

Huang

et al. 2020

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Gu et al found that the citrus peel residue SDF has good antioxidant capacity and can promote intestinal health . Sara et al found that water-soluble dietary fiber Fibersol-2 inhibits the proliferation of colorectal cancer cell SW480 by increasing reactive oxygen species (ROS), while reducing the number of intestinal adenomas in mice …”

Section: Introductionmentioning

confidence: 99%

“…20 Sara et al found that water-soluble dietary fiber Fibersol-2 inhibits the proliferation of colorectal cancer cell SW480 by increasing reactive oxygen species (ROS), while reducing the number of intestinal adenomas in mice. 21 Foxtail millet (Setaria italica L.), an annual grass plant, is widely planted worldwide and is a good source of dietary fiber, vitamins, proteins, minerals, and other nutrients. It has pharmacological properties such as anticancer, anti-inflammatory, antioxidant, hypoglycemic, and intestinal health enhancement.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Soluble Dietary Fiber from Foxtail Millet on Colorectal Cancer by the Restoration of Gut Microbiota

Zhao,

Ren,

Shan

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

Colorectal cancer (CRC) is a common malignant tumor that occurs in the colon. Gut microbiota is a complex ecosystem that plays an important role in the pathogenesis of CRC. Our previous studies showed that the soluble dietary fiber of foxtail millet (FMB-SDF) exhibited significant antitumor activity in vitro. The present study evaluated the anticancer potential of FMB-SDF in the azoxymethane (AOM)- and dextran sodium sulfate (DSS)-induced mouse CRC models. The results showed that FMB-SDF could significantly alleviate colon cancer symptoms in mice. Further, we found that FMB-SDF consumption significantly altered gut microbiota diversity and the overall structure and regulated the abundance of some microorganisms in CRC mice. Meanwhile, KEGG pathway enrichment showed that FMB-SDF can also alleviate the occurrence of colon cancer in mice by regulating certain cancer-related signaling pathways. In conclusion, our findings may provide a novel approach for the prevention and biotherapy of CRC.

show abstract

“…Currently, the prevailing consensus is that short-chain fatty acids, represented by butyrate, were produced by commensal butyrate-producing bacteria in the large intestine [ 12 , 13 , 14 ] through fermentation of non-digestible dietary fibers [ 15 ] like polydextrose (PDX) [ 16 ] and fibersol-2 (FS2) [ 17 ]. Butyrate plays a critical role in maintaining gut epithelial cell homeostasis as their primary energy source, and it could inhibit CRC cells growth and promotes apoptosis by modulating the inhibition of histone deacetylases (HDAC) and NF-kB proinflammatory signaling pathways [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

The Pathogenicity of Fusobacterium nucleatum Modulated by Dietary Fibers—A Possible Missing Link between the Dietary Composition and the Risk of Colorectal Cancer

Nawab

Bao

et al. 2023

Microorganisms

View full text Add to dashboard Cite

The dietary composition has been approved to be strongly associated with the risk of colorectal cancer (CRC), one of the most serious malignancies worldwide, through regulating the gut microbiota structure, thereby influencing the homeostasis of colonic epithelial cells by producing carcinogens, i.e., ammonia or antitumor metabolites, like butyrate. Though butyrate-producing Fusobacterium nucleatum has been considered a potential tumor driver associated with chemotherapy resistance and poor prognosis in CRC, it was more frequently identified in the gut microbiota of healthy individuals rather than CRC tumor tissues. First, within the concentration range tested, the fermentation broth of F. nucleatum exhibited no significant effects on Caco-2 and NCM460 cells viability except for a notable up-regulation of the expression of TLR4 (30.70%, p < 0.0001) and Myc (47.67%, p = 0.021) and genes encoding proinflammatory cytokines including IL1B (197.57%, p < 0.0001), IL6 (1704.51%, p < 0.0001), and IL8 (897.05%, p < 0.0001) in Caco-2 cells exclusively. Although no marked effects of polydextrose or fibersol-2 on the growth of F. nucleatum, Caco-2 and NCM460 cells were observed, once culture media supplemented with polydextrose or fibersol-2, the corresponding fermentation broths of F. nucleatum significantly inhibited the growth of Caco-2 cells up to 48.90% (p = 0.0003, 72 h, 10%) and 52.96% (p = 0.0002, 72 h, 10%), respectively in a dose-dependent manner. These two kinds of fibers considerably promoted butyrate production of F. nucleatum up to 205.67% (p < 0.0001, 6% polydextrose at 24 h) and 153.46% (p = 0.0002, 6% fibersol-2 at 12 h), which explained why and how the fermentation broths of F. nucleatum cultured with fibers suppressing the growth of Caco-2 cells. Above findings indicated that dietary fiber determined F. nucleatum to be a carcinogenic or antitumor bacterium, and F. nucleatum played an important role in the association between the dietary composition, primarily the content of dietary fibers, and the risk of CRC.

show abstract

Fibersol-2 induces apoptosis ofApc-deficient colorectal Cancer (SW480) cells and decreases polyp formation inApcMIN mice

Cited by 6 publications

References 44 publications

Resistant Maltodextrin Alleviates Dextran Sulfate Sodium-Induced Intestinal Inflammatory Injury by Increasing Butyric Acid to Inhibit Proinflammatory Cytokine Levels

Resistant Maltodextrin Alleviates Dextran Sulfate Sodium-Induced Intestinal Inflammatory Injury by Increasing Butyric Acid to Inhibit Proinflammatory Cytokine Levels

Inhibitory Effects of Soluble Dietary Fiber from Foxtail Millet on Colorectal Cancer by the Restoration of Gut Microbiota

The Pathogenicity of Fusobacterium nucleatum Modulated by Dietary Fibers—A Possible Missing Link between the Dietary Composition and the Risk of Colorectal Cancer

Contact Info

Product

Resources

About