Fibre and cancer of the colon

Irving, Doreen; Drašar, B. S.

doi:10.1038/bjc.1973.173

Cited by 55 publications

(4 citation statements)

References 5 publications

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“…The type of fibre recommended is wheat bran, even though the Ugandans with extremely low cancer rates eat vast amounts of banana fibre and very little cereal. Irving and D rasar [31] showed little correlation between the intake of cereal fibre and the incidence of colon cancer. It has been suggested that the increase in incidence of colon cancer over the last 100 years has correlated with a corresponding decrease in fibre intake; Robertson [35] has shown that in fact in the UK no such change in fibre intake has taken place.…”

Section: Populations Living On An Unrefined Diet Rich In Fibre Have Amentioning

confidence: 94%

Colon Cancer: A Disease of Fibre Depletion or of Dietary Excess ?

Hill¹

1974

Digestion

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It cannot be denied that the fibre theory is attractive and appears to be firmly based in ‘common sense’ – one would expect a priori that all of the statements are likely to be true. When further investigated, however, we find that ‘common sense’ has again let us down and that an expected relation is in fact reversed simply because the situation is much more complex than expected (the best example is the lack of relation between bowel transit time and the degree of bacterial degradation of fecal steroids, etc.). There is little virtue in criticising a hypothesis unless a better one can be suggested as a replacement. I would therefore like to reiterate the hypothesis that I and my colleagues have been investigating. We believe that it offers a better rationalisation of the facts.

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Section: Populations Living On An Unrefined Diet Rich In Fibre Have Amentioning

confidence: 94%

Colon Cancer: A Disease of Fibre Depletion or of Dietary Excess ?

Hill¹

1974

Digestion

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“…A possible correlation between dietary factors such as meat, total fat, and incidence of colon cancer has been reported (241)(242)(243). Factors such as paucity of dietary fiber (244), nonnutritive substances in food (245), certain food additives, and by-products arising from frying or barbecuing meat or fish (246) have also been implicated. Reddy et al (247,248) observed that the incidence of dimethylhydrazine (DMH)-Downloaded by [New York University] at 12:05 23 May 2015 induced colon cancer was higher in animals consuming diets rich in animal protein and fat.…”

Section: Prevention Of Colon Cancermentioning

confidence: 99%

Acidophilus milk products: Manufacture and therapeutics

Mital

Garg

1992

Food Reviews International

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Consumption of acidophilus milk products as a dietary adjunct is considered to impart many health benefits. These include (i) control of intestinal infections, (ii) stabilization of intestinal microflora, (iii) control of serum cholesterol level, (iv) prevention of colon cancer, and (v) enhanced availability of nutrients. However, L. acidophilus grows slowly in milk, which results in overgrowth of other microorganisms present. Hence, acidophilus milk products are characterized by an unpleasant flavor and are not acceptable as a normal component of diet. Attempts have, therefore, been made to manufacture acceptable acidophilus milk products possessing wider consumer appeal. The manufacturing and therapeutical aspects of acidophilus milk products are discussed in this review.

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“…Geographic correlation studies have generally supported a negative association between dietary fiber (DF) and colorectal cancer risk, but they are of limited value (Irving and Drasar, 1973; Bingham, 1985). Several population comparison studies with fiber intake data for individual subjects have suggested a protective effect of fiber against colon cancer incidence (Englyst et al, 1982;Jensen et al, 1982;Reddy et al, 1983;Rosen et al, 1988).…”

mentioning

confidence: 99%

Diet and colorectal cancer with special reference to fiber intake

Heilbrun

Nomura

Hankin

et al. 1989

Intl Journal of Cancer

128

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In this nested case-control study, 8,006 American Japanese men were examined and interviewed with a dietary questionnaire from 1965 to 1968. After a follow-up period of over 16 years, 102 colon and 60 rectal cancer incident cases were identified. Dietary data from these patients and from 361 cancer-free controls were analyzed for intake of dietary fiber (DF), vitamins, minerals, macronutrients, and selected food groups. We found a significant (p = 0.042) negative association of DF and colon cancer risk among low fat intake men (less than 61 g/d). In this subgroup, the men consuming less than 7.5 g/d of DF had an adjusted relative risk (RR) for colon cancer of 2.28 (95% CI 0.93-5.60), compared to those consuming greater than or equal to 14.8 g/d of DF. We also observed (among the complete group of subjects) a significant (p = 0.011) negative association between vitamin C intake and the risk of colon cancer. Men in the lowest quintile of vitamin C intake (less than 37 mg/d) had an adjusted colon cancer RR of 1.87 (95% CI 1.03-3.37), compared to men in the highest quintile (greater than or equal to 160 mg/d). We view these dietary associations with colon cancer risk with caution. There were no other significant associations of dietary variables with colon cancer risk. Also, there were no significant associations between intake levels of DF, micronutrients, or food groups and rectal cancer risk.

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Fibre and cancer of the colon

Cited by 55 publications

References 5 publications

Colon Cancer: A Disease of Fibre Depletion or of Dietary Excess ?

Colon Cancer: A Disease of Fibre Depletion or of Dietary Excess ?

Acidophilus milk products: Manufacture and therapeutics

Diet and colorectal cancer with special reference to fiber intake

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