Fibre-optic coupling to high-resolution CCD and CMOS image sensors

Silfhout, R. G. van; Kachatkou, Anton

doi:10.1016/j.nima.2008.09.015

Cited by 13 publications

(14 citation statements)

References 7 publications

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“…In this case, removal of the CMOS glass lid and positioning of the FOP directly on the pixel area may be investigated. 42 Moreover, validation of the system on skin-mimicking multilayer phantoms should be conducted. In order to further increase the sensitivity of diffuse reflectance spectra to superficial layers, several authors have explored the use of oblique illumination.…”

Section: Discussionmentioning

confidence: 99%

Contact, high-resolution spatial diffuse reflectance imaging system for skin condition diagnosis

et al. 2018

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Spatially resolved diffuse reflectance spectroscopy (srDRS) is a well-established technique for noninvasive, in vivo characterization of tissue optical properties toward diagnostic applications. srDRS has a potential for depth-resolved analysis of tissue, which is desired in various clinical situations. However, current fiber-based and photodiode-based systems have difficulties achieving this goal due to challenges in sampling the reflectance with a high enough resolution. We introduce a compact, low-cost architecture for srDRS based on the use of a multipixel imaging sensor and light-emitting diodes to achieve lensless diffuse reflectance imaging in contact with the tissue with high spatial resolution. For proof-of-concept, a prototype device, involving a commercially available complementary metal-oxide semiconductor coupled with a fiber-optic plate, was fabricated. Diffuse reflectance profiles were acquired at 645 nm at source-to-detector separations ranging from 480 μm to 4 mm with a resolution of 16.7 μm. Absorption coefficients (μ a ) and reduced scattering coefficients (μ 0 s ) of homogeneous tissue-mimicking phantoms were measured with 4.2 AE 3.5% and 7.0 AE 4.6% error, respectively. The results obtained confirm the potential of our approach for quantitative characterization of tissue optical properties in contact imaging modality. This study is a first step toward the development of low-cost, wearable devices for skin condition diagnosis in vivo.

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Section: Discussionmentioning

confidence: 99%

Contact, high-resolution spatial diffuse reflectance imaging system for skin condition diagnosis

et al. 2018

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“…Bottom: the reconstructed cross-sectional image with the corresponding horizontal image profile (left inset) and the image obtained by exposing the X-ray camera directly to the beam (right inset). XBI parameters: L/D = 2, 50 mm copper foil, = 18.7 , CMOS detector with 7 mm pixels fibre-optically coupled with a Gd 2 O 2 S : Tb scintillator foil (van Silfhout & Kachatkou, 2008), integration time 0.25 s. position measurements by improving the SNR of the measured image profiles. Moreover, the resolution of beam position measurements can be increased even when using the cross aperture with the width of slits considerably smaller than the diameter of the pinhole.…”

Section: Discussionmentioning

confidence: 99%

“…First, one needs the XBI impulse response which can be calculated a priori for a given foil material, the detector and known device dimensions. The detector's PSF can be obtained from the manufacturer or measured separately ( van Silfhout & Kachatkou, 2008). The effect of the XBI impulse response is then removed by resorting to one of the well established deconvolution techniques (Jansson, 2012).…”

Section: Image Reconstructionmentioning

confidence: 99%

“…Other XBI parameters: 125 mm Kapton foil, = 27.8 , and L = 5 mm, D = 10 mm, CMOS detector with 7 mm pixels fibre-optically coupled with a Gd 2 O 2 S : Tb scintillator foil (vanSilfhout & Kachatkou, 2008), integration time 3 s.…”

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confidence: 99%

“…Images of a 50 mm-thick gold wire placed into an unfocused monochromatic (15 keV) beam at bending-magnet beamline B16 (DLS, UK): direct image taken with an X-ray microscope (left); raw XBI image obtained using 400 mm circular aperture and L/D = 2 (centre); beam cross-section image reconstructed using 20 Lucy-Richardson iterations (right). Other XBI parameters: 125 mm Kapton foil, = 27.8 , and L = 5 mm, D = 10 mm, CMOS detector with 7 mm pixels fibre-optically coupled with a Gd 2 O 2 S : Tb scintillator foil (vanSilfhout & Kachatkou, 2008), integration time 3 s.…”

mentioning

confidence: 99%

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