Fibrin Adsorption on Cardiovascular Biomaterials and Medical Devices

Nzulumike, Achebe N.O.; Thormann, Esben

doi:10.1021/acsabm.2c01057

Cited by 8 publications

(3 citation statements)

References 71 publications

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“…The coatings were washed with excess water to remove any unattached material and dried under nitrogen before storage or use. AFM imaging, reported in a recent work, revealed that the dry coatings are flat with a root-mean-square roughness of around 0.5 nm. Further, the coatings proved to be robust and stable during repeated ice adhesion measurements (see Supporting Information, Figure S14).…”

Section: Methodsmentioning

confidence: 80%

Reducing Ice Adhesion to Polyelectrolyte Surfaces by Counterion-Mediated Nonfrozen Hydration Water

Biro,

Tyrode,

Thormann

2024

ACS Appl. Mater. Interfaces

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Hydrophilic anti-icing coatings can be energy-effective passive solutions for combating ice accretion and reducing ice adhesion. However, their underlying mechanisms of action remain inferential and are ill-defined from a molecular perspective. Here, we systematically investigate the influence of the counterion identity on the shear ice adhesion strength to cationic polymer coatings having quaternary alkyl ammonium moieties as chargeable groups. Temperature-dependent molecular information on the hydrated polymer films is obtained using total internal reflection (TIR) Raman spectroscopy, complemented with differential scanning calorimetry (DSC) and ellipsometry. Ice adhesion measurements show a pronounced counterion-specific behavior with a sharp increase in adhesion at temperatures that depend on the anion identity, following the order Cl − < F − < SCN − < Br − < I − . Linked to the freezing of hydration water, the specific ordering results from differences in ion pairing and the amount of water present within the polymer film. Moreover, similar effects can be promoted by varying the cross-linking density in the coating while keeping the anion identity fixed. These findings shed new light on low ice adhesion mechanisms and may inspire novel approaches for improved anti-icing coatings.

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Section: Methodsmentioning

confidence: 80%

Reducing Ice Adhesion to Polyelectrolyte Surfaces by Counterion-Mediated Nonfrozen Hydration Water

Biro,

Tyrode,

Thormann

2024

ACS Appl. Mater. Interfaces

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“…Native fibrin is deposited at the site of arterial injury and, in part, determines the neointimal response, according to studies in the porcine coronary model. This evidence served as the impetus for the initial investigation into how fibrin-coated stents affected the arterial wall [79]. Twenty animals received 34 of these stents using the same porcine coronary model, and there were no immediate complications.…”

Section: Fibrin-based Coatingsmentioning

confidence: 99%

Coatings for Cardiovascular Stents—An Up-to-Date Review

Udriște,

Burdușel,

Niculescu

et al. 2024

IJMS

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Cardiovascular diseases (CVDs) increasingly burden health systems and patients worldwide, necessitating the improved awareness of current treatment possibilities and the development of more efficient therapeutic strategies. When plaque deposits narrow the arteries, the standard of care implies the insertion of a stent at the lesion site. The most promising development in cardiovascular stents has been the release of medications from these stents. However, the use of drug-eluting stents (DESs) is still challenged by in-stent restenosis occurrence. DESs’ long-term clinical success depends on several parameters, including the degradability of the polymers, drug release profiles, stent platforms, coating polymers, and the metals and their alloys that are employed as metal frames in the stents. Thus, it is critical to investigate new approaches to optimize the most suitable DESs to solve problems with the inflammatory response, delayed endothelialization, and sub-acute stent thrombosis. As certain advancements have been reported in the literature, this review aims to present the latest updates in the coatings field for cardiovascular stents. Specifically, there are described various organic (e.g., synthetic and natural polymer-based coatings, stents coated directly with drugs, and coatings containing endothelial cells) and inorganic (e.g., metallic and nonmetallic materials) stent coating options, aiming to create an updated framework that would serve as an inception point for future research.

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“…The most widespread medicaltechnological products containing noble metals are diagnostic electrophysiology catheters, diagnostic guide wires, and self-expanding stents. Such products contain Pt/Ir alloy marker bands [6], Au-coating media [7], and Ta marker dots at each edge [8], respectively.…”

Section: Introductionmentioning

confidence: 99%

Recovery of Noble Metals (Au, Pt, Ir, and Ta) from Spent Single-Use Medical–Technological Products

Kokkinos,

Prochaska,

Lampou

et al. 2024

Minerals

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Due to their unique properties, i.e., fluoroscopy response and inertness, noble metals and alloys are present in several widespread medical–technological products, such as catheters, guide-wires, and stents. Despite their value, these products serve as single-use consumables, following a fate of solid waste disposal and loss of their valuable metals. This work studies the development of a treatment methodology to recover noble metals such as Pt, Ir, Au, and Ta from certain commercial products commonly used for medical practices. In particular, a sequence of preliminary pyrolysis, aiming at polymer elimination, as well as an acid digestion step for selective metals dissolution, is suggested. Pyrolysis was capable of enriching samples with the targeted metals, though a small change in their oxidation states was observed. Still, acid digestion was fully able to successfully separate Au using a 50% v/v aqua regia solution for 30 min at room temperature and the Pt/Ir using concentrated aqua regia for 72 h under heating. Dissolution of Ta required a different leaching solution, i.e., a 50% v/v HF/H2SO4 mixture for 10 h under heating. According to the developed method, selective extraction of such noble metals in a concentrated slurry provides a high potential for the complete recovery and valorization of otherwise disposed medical wastes.

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Fibrin Adsorption on Cardiovascular Biomaterials and Medical Devices

Cited by 8 publications

References 71 publications

Reducing Ice Adhesion to Polyelectrolyte Surfaces by Counterion-Mediated Nonfrozen Hydration Water

Reducing Ice Adhesion to Polyelectrolyte Surfaces by Counterion-Mediated Nonfrozen Hydration Water

Coatings for Cardiovascular Stents—An Up-to-Date Review

Recovery of Noble Metals (Au, Pt, Ir, and Ta) from Spent Single-Use Medical–Technological Products

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