Fibrin-based cardiac patch containing neuregulin-1 for heart repair after myocardial infarction

Chang, Tianqi; Liu, Chunxia; Yang, Hong; Lu, Kunyan; Han, Yanchao; Zheng, Yu; Huang, Haoyue; Wu, Yong; Song, Yumeng; Yu, Qian; Shen, Zhenya; Jiang, Tingbo; Zhang, Yanxia

doi:10.1016/j.colsurfb.2022.112936

Cited by 20 publications

(12 citation statements)

References 51 publications

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“…Currently, the approaches for preventing cardiac fibrosis after MI generally involve i) application of biomaterials (e.g., injectable hydrogels and cardiac patches), to support the infarcted tissue and reduce elevated wall stress, [10][11][12][13][14][15][16] and ii) delivery of antifibrotic drugs or bioactive factors to inhibit specific signaling pathways related to fibrosis (e.g., transforming growth factor-𝛽 (TGF-𝛽)-related signaling pathways that play a dominant role in myocardial fibrosis by inducing the transformation of cardiac fibroblasts into myofibroblasts and promoting the production and deposition of collagens). [17][18][19][20][21] Recently, microRNAs (miRNAs), a class of small noncoding RNAs that play crucial roles in regulating gene expression, have been discovered to treat fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Microneedle Patch Loaded with Exosomes Containing MicroRNA‐29b Prevents Cardiac Fibrosis after Myocardial Infarction

Yuan

Yang

Liu

et al. 2023

Adv Healthcare Materials

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Myocardial infarction (MI) is a cardiovascular disease that poses a serious threat to human health. Uncontrolled and excessive cardiac fibrosis after MI has been recognized as a primary contributor to mortality by heart failure. Thus, prevention of fibrosis or alleviation of fibrosis progression is important for cardiac repair. To this end, a biocompatible microneedle (MN) patch based on gelatin is fabricated to load exosomes containing microRNA-29b (miR-29b) mimics with antifibrotic activity to prevent excessive cardiac fibrosis after MI. Exosomes are isolated from human umbilical cord mesenchymal stem cells and loaded with miR-29b mimics via electroporation, which can be internalized effectively in cardiac fibroblasts to upregulate the expression of miR-29b and downregulate the expression of fibrosis-related proteins. After being implanted in the infarcted heart of a mouse MI model, the MN patch can increase the retention of loaded exosomes in the infarcted myocardium, leading to alleviation of inflammation, reduction of the infarct size, inhibition of fibrosis, and improvement of cardiac function. This design explored the MN patch as a suitable platform to deliver exosomes containing antifibrotic biomolecules locally for the prevention of cardiac fibrosis, showing the potential for MI treatment in clinical applications.

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Section: Introductionmentioning

confidence: 99%

Microneedle Patch Loaded with Exosomes Containing MicroRNA‐29b Prevents Cardiac Fibrosis after Myocardial Infarction

Yuan

Yang

Liu

et al. 2023

Adv Healthcare Materials

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“…Their engineering with magnetic nanoparticles or carbon nanotubes further contributed to improving cell alignment and electrical crosstalk ( Sun et al, 2017 ; Yu et al, 2017 ; Zwi-Dantsis et al, 2020 ). Besides collagen I, other natural materials found large use to manufacture hydrogels for cardiac applications, as the collagen-originated gelatin, the brown seaweed-derived alginate, the coagulation-related fibrin, the non-sulfated linear glycosaminoglycan hyaluronic acid, the crustacean chitosan, or their combinations ( So et al, 2009 ; Nezhad-Mokhtari et al, 2020 ; Sisso et al, 2020 ; Zhang et al, 2022a ; Chang et al, 2022 ; Tohidi et al, 2022 ; Wu et al, 2023 ). Hydrogel composites can better replicate the thin and delicate ECM network typical of the myocardium.…”

Section: Biomimetic Design: From Extracellular Matrix To Scaffoldmentioning

confidence: 99%

Advances in the design, generation, and application of tissue-engineered myocardial equivalents

Bernava,

Iop

2023

Front. Bioeng. Biotechnol.

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Due to the limited regenerative ability of cardiomyocytes, the disabling irreversible condition of myocardial failure can only be treated with conservative and temporary therapeutic approaches, not able to repair the damage directly, or with organ transplantation. Among the regenerative strategies, intramyocardial cell injection or intravascular cell infusion should attenuate damage to the myocardium and reduce the risk of heart failure. However, these cell delivery-based therapies suffer from significant drawbacks and have a low success rate. Indeed, cardiac tissue engineering efforts are directed to repair, replace, and regenerate native myocardial tissue function. In a regenerative strategy, biomaterials and biomimetic stimuli play a key role in promoting cell adhesion, proliferation, differentiation, and neo-tissue formation. Thus, appropriate biochemical and biophysical cues should be combined with scaffolds emulating extracellular matrix in order to support cell growth and prompt favorable cardiac microenvironment and tissue regeneration. In this review, we provide an overview of recent developments that occurred in the biomimetic design and fabrication of cardiac scaffolds and patches. Furthermore, we sift in vitro and in situ strategies in several preclinical and clinical applications. Finally, we evaluate the possible use of bioengineered cardiac tissue equivalents as in vitro models for disease studies and drug tests.

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“…Biomaterials possess customizable carrier properties that enable a continuous and local release of factors, as well as provide mechanical support to the injured area and bioactive cues for cell adhesion, survival, and differentiation. − Alginate (Alg) is a natural anion polysaccharide extracted from brown algae, which can be cross-linked with divalent cations to form hydrogel with a certain viscosity and mechanical strength . This polymer offers modifiable properties and is a nonthrombogenic biomaterial, making it a suitable candidate for cardiac applications .…”

Section: Introductionmentioning

confidence: 99%

Annexin A1-Loaded Alginate Hydrogel Promotes Cardiac Repair via Modulation of Macrophage Phenotypes after Myocardial Infarction

Zhang,

Shao,

et al. 2024

ACS Biomater. Sci. Eng.

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Myocardial infarction (MI) is associated with inflammatory reaction, which is a pivotal component in MI pathogenesis. Moreover, excessive inflammation post-MI can lead to cardiac dysfunction and adverse remodeling, emphasizing the critical need for an effective inflammation-regulating treatment for cardiac repair. Macrophage polarization is crucial in the inflammation process, indicating its potential as an adjunct therapy for MI. In this study, we developed an injectable alginate hydrogel loaded with annexin A1 (AnxA1, an endogenous anti-inflammatory and pro-resolving mediator) for MI treatment. In vitro results showed that the composite hydrogel had good biocompatibility and consistently released AnxA1 for several days. Additionally, this hydrogel led to a reduced number of pro-inflammatory macrophages and an increased proportion of pro-healing macrophages via the adenosine monophosphate (AMP)-activated protein kinase (AMPK)-mammalian target of the rapamycin (mTOR) axis. Furthermore, the intramyocardial injection of this composite hydrogel into a mouse MI model effectively modulated macrophage transition to pro-healing phenotypes. This transition mitigated early inflammatory responses and cardiac fibrosis, promoted angiogenesis, and improved cardiac function. Therefore, our study findings suggest that combining biomaterials and endogenous proteins for MI treatment is a promising approach for limiting adverse cardiac remodeling, preventing cardiac damage, and preserving the function of infarcted hearts.

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Fibrin-based cardiac patch containing neuregulin-1 for heart repair after myocardial infarction

Cited by 20 publications

References 51 publications

Microneedle Patch Loaded with Exosomes Containing MicroRNA‐29b Prevents Cardiac Fibrosis after Myocardial Infarction

Microneedle Patch Loaded with Exosomes Containing MicroRNA‐29b Prevents Cardiac Fibrosis after Myocardial Infarction

Advances in the design, generation, and application of tissue-engineered myocardial equivalents

Annexin A1-Loaded Alginate Hydrogel Promotes Cardiac Repair via Modulation of Macrophage Phenotypes after Myocardial Infarction

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