Fibrin Degradation Products in Pre-Eclamptic Toxaemia and Eclampsia

Henderson, A. H.; Pugsley, D. J.; Thomas, Duncan P.

doi:10.1097/00006254-197104000-00007

Cited by 3 publications

(4 citation statements)

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“…The present study has revealed evidence of increased in travascular coagulation in many patients with gestational hypertension and especially pre-eclampsia, thus confirming earlier observations (Henderson et al 1970, Bonnar et al 197 1, Starkie et al 1971, McKillop et al 1976. The proportion of patients who displayed abnormal results varied with the severity of their clinical condition and with the different tests (Table 5).…”

Section: Discussionsupporting

confidence: 91%

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Intravascular coagulation in gestational hypertension and pre-eclampsia: the value of haematological screening tests

Giles¹

2008

Clinical &Amp; Laboratory Haematology

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Summary. Routine investigations designed to detect excessive intravascular coagulation in patients with gestational hypertension and pre‐eclampsia have been analysed in 936 cases. Reticulocyte counts did not differ significantly from those in normal controls and abnormal red cell morphology was detected in only two patients. Fibrinogen degradation products and thrombocytopenia were found in about 10% of all hypertensive women and macrothrombocytosis in 32%. Neither reticulocyte counts nor the scanning of stained blood films for evidence of microangiopathic haemolysis have a place in the routine investigation of preeclampsia and it is doubtful whether any of the other screening tests can influence the management of patients with uncomplicated gestational hypertension. In fully developed pre‐eclampsia, macrothrombocytosis is found in about 50% of patients, fibrinogen degradation products and thrombocytopenia in about 15%. All three parameters reflect the degree of clinical severity of the disease.

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Section: Discussionsupporting

confidence: 91%

“…In pre-eclampsia intravascular coagulation is intensified ; fibrinogen degradation products (FDP) increase both in the blood (Henderson et al 1970, McKillop et al 1976) and urine (Preston et al 1972), the platelet count tends to fall (Bonnar et al 1971, Starkie et al 1971) and there is rise in the mean platelet volume , Giles & Inglis 1981.…”

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confidence: 99%

Intravascular coagulation in gestational hypertension and pre-eclampsia: the value of haematological screening tests

Giles¹

2008

Clinical &Amp; Laboratory Haematology

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“…Intravasal coagulation with increased fibrinolysis and split products have been demonstrated in most cases of eclampsia (DAVID- SON et al 1972, HENDERSON et al 1970, REID et al 1971, STARKIE et al 1971, WARDLE 1971.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Pre‐eclampsia and Eclampsia as a Hypoperfusion Syndrome

Söder

GRENROTH

Norée

et al. 1975

Acta Anaesthesiol Scand

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A therapeutical program in pre-eclampsia and eclampsia is presented. The results in 10 patients suggest that the same basic program as is used in the hypoperfusion syndrome can be used in pre-eclampsia and eclampsia:Chlorpromazin to combat vasoconstriction and dilate the vascular bed. Plasma expanders, plasma, albumin and glucose with electrolytes to fill up Buffers to combat acidosis, oxygen to combat hypoxemia, hypertonic Manni-Furosemide to force diuresis.the dilated vascular bed and restore the tissue perfusion.to1 to mobilize edema.

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“…A n u m b e r of studies have shown that gestosis (preeclampsia; toxaemia) is always accompanied by thickening of the glomerular basement membrane a n d swelling of the endothelium (8,9), which is a result of disseminated intravascular coagulation (4,11). T h e proteinuria in gestosis is the result of the increased glomerular permeability present in this disease (2).…”

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confidence: 99%

The Urine‐Plasma Ratio of Some Proteins in Gestosis

Tervilä

Vartiainen

Timonen

et al. 1975

Acta Obstet Gynecol Scand

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Abstroct. The urine and plasma content of certain proteins was studied near term in healthy gravidas, in gravidas with essential hypertension, proteinuria, hypertension of pregnancy and gestosis (pre-eclampsia; toxaemia). besides this the ratio of urine-plasma concentrations for each protein was calculated. In gestosis only the urine-plasma ratio of ceruloplasmin differed from those of the other proteins, but in the other diseases studied this ratio showed no difference from that in healthy gravidas. The amounts of different proteins excreted in urine did not correlate with the molecular size of the respective protein.A n u m b e r of studies have shown that gestosis (preeclampsia; toxaemia) is always accompanied by thickening of the glomerular basement membrane a n d swelling of the endothelium (8,9), which is a result of disseminated intravascular coagulation (4, 11). T h e proteinuria in gestosis is the result of the increased glomerular permeability present in this disease (2). It has been s h o w n that the clearance rate of plasma proteins is dependent upon molecular weight a n d that it decreases in proportion with higher molecular weight (3, 5). This simple selectivity is also found in gestosis (10).Attempts have been made t o find, f o r s o m e proteins, a urine-plasma ratio characteristic of gestosis (6, 12) b u t no definitely specific protein has been detected. Since the discovery o f such a specific protein might be of great importance in differentialThe series studied consisted of 15 healthy pregnant women and 22 gravidas with essential hypertension, 3 with proteinuria of late pregnancy, 17 with hypertension of late pregnancy and 8 with gestosis. The criteria of gestosis were a pathological blood pressure and proteinuiia. The upper limit of normal blood pressure was set at 140/90 mmHg and the highest normal proteinuria at 0.3 g/24 h, measured by Esbach's method. Gestosis was considered as a complication of late pregnancy if it had begun in the 26th week of gestation at the earliest. At the time of study the pregnancies were all in the 36th4Oth week of gestation. All the fetuses were alive.Of the collected 24-hour urine, 400 ml was concentrated to 10 ml. Concentration was done under nitrogen pressure, using a magnetic mixer and ultrafiltration apparatus (Amicon N.V., Oosterhout, Holland). The same manufacturer's filter paper XM-50 was used, allowing particles of molecular weight 50 OOO to remain in the solution to be studied.Twenty ml of blood was obtained from the cubital vein and centrifuged immediately. The plasma was studied without concentration.From both groups of samples 8 proteins were determined in mg per to0 ml, using radial immunodiffusion containing specific antiserum (Partigen plates, Behringwerke AG, Marburg, BRD)' (7). The standard sera of the same manufacturer were used as standards. The standard deviation of the method was less than 2% of the mean.The proteins to be studied were selected so as to be representative of different molecular sizes, but nevertheless were within the limits...

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Fibrin Degradation Products in Pre-Eclamptic Toxaemia and Eclampsia

Cited by 3 publications

References 4 publications

Intravascular coagulation in gestational hypertension and pre-eclampsia: the value of haematological screening tests

Intravascular coagulation in gestational hypertension and pre-eclampsia: the value of haematological screening tests

Treatment of Pre‐eclampsia and Eclampsia as a Hypoperfusion Syndrome

The Urine‐Plasma Ratio of Some Proteins in Gestosis

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