Fibrin Glue

Singh, Kimberly A.; Moyer, Hunter R.; Williams, Joseph K.; Schwartz, Zvi; Boyan, Barbara D.

doi:10.1097/sap.0b013e3181fc0507

Cited by 18 publications

(2 citation statements)

References 18 publications

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“…It has been widely used in many surgical disciplines including cranioplasty [12], spine surgery [13,14], and maxillofacial surgery [10,15,16]. Beside its hemostatic capabilities, FG has been employed as scaffolds for bone and cartilage tissue engineering [17][18][19]. It has been studied in vitro studies that the addition of fibrin network to collagen sponge increased the osteoblast differentiation in a dose-dependent way, suggesting that these materials may favor bone repair [20].…”

Section: Introductionmentioning

confidence: 99%

Effect of fibrin glue on the healing efficacy of deproteinized bovine bone and autologous bone in critical-sized calvarial defects in rats

Bajwa

Shi

et al. 2022

Clin Oral Invest

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Section: Introductionmentioning

confidence: 99%

Effect of fibrin glue on the healing efficacy of deproteinized bovine bone and autologous bone in critical-sized calvarial defects in rats

Bajwa

Shi

et al. 2022

Clin Oral Invest

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“…Several recent studies showed reproducible cartilage formation in the defect of rat xiphoid. 28 - 30 They also showed that the formation of neocartilage in rat xiphoid was increased with fibroblast growth factor-2 in the absence of exogenous chondrocytes. 30 Since xiphoid cartilage in mice is subcutaneous, it allows for easy access; only limited surgical exposure is required, and the placement of the tissue allows for the application of consistent and quantifiable mechanical injury.…”

Section: Introductionmentioning

confidence: 94%

Posttraumatic Chondrocyte Apoptosis in the Murine Xiphoid

et al. 2013

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Objective. To demonstrate posttraumatic chondrocyte apoptosis in the murine xiphoid after a crush-type injury and to ultimately determine the pathway (i.e., intrinsic or extrinsic) by which chondrocytes undergo apoptosis in response to mechanical injury. Design. The xiphoids of adult female wild-type mice were injured with the use of a modified Kelly clamp. Postinjury xiphoid cartilage was analyzed via 3 well-described independent means of assessing apoptosis in chondrocytes: hematoxylin and eosin staining, terminal deoxynucleotidyl transferase dUTP nick end labeling assay, and activated caspase-3 staining. Results. Injured specimens contained many chondrocytes with evidence of apoptosis, which is characterized by cell shrinkage, chromatin condensation, nuclear fragmentation, and the liberation of apoptotic bodies. There was a statistically significant increase in the number of chondrocytes undergoing apoptosis in the injured specimens as compared with the uninjured specimens. Conclusions. Chondrocytes can be stimulated to undergo apoptosis as a result of mechanical injury. These experiments involving predominantly cartilaginous murine xiphoid in vivo establish a baseline for future investigations that employ the genetic and therapeutic modulation of chondrocyte apoptosis in response to mechanical injury.

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