Fibrin Glue Reduces Intra-Abdominal Adhesions to Synthetic Mesh in a Rat Ventral Hernia Model

Toosie, Katayoun; Gallego, Kelly; Stabile, Bruce E.; Schaber, Bethann; French, Samuel W.; Virgilio, Christian de

doi:10.1177/000313480006600109

Cited by 57 publications

(1 citation statement)

References 14 publications

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“…Sheppard and associates [33] demonstrated in a long‐term model that animals treated with wound sealing had significantly less high‐grade adhesions. In addition, sealing of wound tissues might decrease inflammatory processes following surgical interventions, and thus to a reduction of adhesion formation [12, 38].…”

Section: Discussionmentioning

confidence: 99%

Autologous platelet gel and fibrin sealant enhance the efficacy of total knee arthroplasty: improved range of motion, decreased length of stay and a reduced incidence of arthrofibrosis

Everts

Devilee

Oosterbos

et al. 2007

Knee Surg Sports Traumatol Arthr

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In this study we describe the potential role of autologous platelet gel and fibrin sealant in unilateral total knee arthroplasty to improve the postoperative range of motion and to reduce the incidence of arthrofibrosis. Total knee arthroplasty is often associated with a considerable amount of post-operative blood loss. Persistent limited motion directly after surgery may ultimately result in arthrofibrosis. To counteract these effects we investigated whether the use of autologous derived platelet gel and fibrin sealant would reduce postoperative blood loss, decrease the impaired range of motion and the incidence of arthrofibrosis. All patients were consecutively operated and assigned to the study or control groups. Study group patients (n = 85) were treated with the application of autologous platelet gel and fibrin sealant at the end of surgery. Eighty patients were operated without the use of platelet gel and fibrin sealant, and served as the control group. The postoperative hemoglobin decrease, range of motion and length of hospitalization were recorded. During a 5-month postoperative period patients were followed to observe the incidence of arthrofibrosis. In patients in the treatment group the hemoglobin concentration in blood decreased significantly less when compared to the control group. They also showed a superior postoperative range of motion when compared to those of the control group (P < 0.001). The incidence of arthrofibrosis and subsequent forced manipulation was significantly less (P < 0.001) in patients managed with platelet gel and fibrin sealant. We conclude that peri-operatively applied platelet gel and fibrin sealant may improve the range of motion after total knee arthroplasty, decreases the length of stay and may reduce the incidence of arthrofibrosis.

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Section: Discussionmentioning

confidence: 99%

Autologous platelet gel and fibrin sealant enhance the efficacy of total knee arthroplasty: improved range of motion, decreased length of stay and a reduced incidence of arthrofibrosis

Everts

Devilee

Oosterbos

et al. 2007

Knee Surg Sports Traumatol Arthr

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The effect of tranexamic acid in fibrin sealant on adhesion formation in the rat

Wiseman

Lyachovetsky²,

Keidan

et al. 2003

J Biomed Mater Res

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The objective of the research was to determine the effect of the type, dose, and volume of anti-fibrinolytic agents (tranexamic acid, aprotinin) added to fibrin formulations, on adhesion development. Adhesions were induced in 228 male rats by creating apposing parietal and visceral peritoneal defects. Animals were randomized to receive no treatment or a fibrin formulation containing aprotinin or tranexamic acid. Seven days later the incidence of adhesions, and the force and energy required to detach them, were determined. Adhesions developed in 13/13 rats in the control and aprotinin groups. Treatment with fibrin (100 mg/ml tranexamic acid) resulted in adhesions in 4/14 rats (as strips, p < or = 0.0005), 4/10 rats (as spray, p < or = 0.0036), and 12/15 rats (by drip). The reduction of adhesions was dependent on the concentration of tranexamic acid with strip and spray application. Using commercial formulations, tranexamic-acid-containing fibrin (10/15, p = 0.042), but not aprotinin-containing fibrin (13/15), reduced the incidence of side-wall adhesions from 15/15 in controls. Fibrin containing either tranexamic or aprotinin reduced the incidence and severity of adhesions. This effect was greater when tranexamic acid was used and was dependent on the mode of administration, the volume, and to a degree, the concentration of tranexamic acid.

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Improved surgical outcome by modification of porcine dermal collagen implant in abdominal wall reconstruction in rats

Zheng

Verbeken

Ridder

et al. 2005

Neurourology and Urodynamics

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Fibrin Glue Reduces Intra-Abdominal Adhesions to Synthetic Mesh in a Rat Ventral Hernia Model

Cited by 57 publications

References 14 publications

Autologous platelet gel and fibrin sealant enhance the efficacy of total knee arthroplasty: improved range of motion, decreased length of stay and a reduced incidence of arthrofibrosis

Autologous platelet gel and fibrin sealant enhance the efficacy of total knee arthroplasty: improved range of motion, decreased length of stay and a reduced incidence of arthrofibrosis

The effect of tranexamic acid in fibrin sealant on adhesion formation in the rat

Improved surgical outcome by modification of porcine dermal collagen implant in abdominal wall reconstruction in rats

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