Fibrin hydrogel incorporated with graphene oxide functionalized nanocomposite scaffolds for bone repair — In vitro and in vivo study

Pathmanapan, Srinivetha; Prabu, P.; Anandasadagopan, Suresh Kumar

doi:10.1016/j.nano.2020.102251

Cited by 53 publications

(53 citation statements)

References 47 publications

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“…Despite the fact that the performed numerical modeling requires direct in vitro analysis for a detailed study of the influence of the shape and pore size of scaffolds, the type of nutrient and its composition, on the growth of cells, our studies are in agreement with a number of works [49][50][51]. Moreover, the numerical results of our studies on the rate of diffusion flow of nutrients at a certain rate of rotation of the scaffold were lower than the actual rate of particle movement, observed in these works.…”

Section: Results Of Internal Flow Modelingsupporting

confidence: 85%

A Numerical Study of Fluid Flow in the Porous Structure of Biological Scaffolds

Daulbayev

Mansurov

Sultanov

et al. 2020

Eurasian Chem. Tech. J.

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Tissue engineering (TE) is one of the promising areas that aims to address the global problem of organ and tissue shortages. The successful development of TE, particularly in bone tissue engineering, consists of the use of modern methods that allow the creation of scaffolds, the physicochemical, mechanical, and structural parameters of which will allow achieving the desired clinical results. The vast possibilities of the rapidly developing technology of three-dimensional (3D) printing, which allows the creation of individual scaffolds with high precision, has led to various developments in bone tissue TE. In this work, for the successful use of three-dimensional printing in TE to ensure the diffusion of nutrients during cell cultivation throughout the entire structure of the scaffold, a model of a rotating scaffold is proposed, and the movement of the diffusion flow of nutrient fluid is calculated based on Darcy’s law, which regulates the flow of fluids through porous media. The conducted studies of the rate of diffusion flow of nutrients based on glucose in the porous structure of scaffolds with a 10% content of calcium hydroxyapatite demonstrated the promise of using a model of a rotating composite scaffold in TE of bone tissue. The results show that at a scaffold rotation speed of 12 rpm, the diffusion flow rate of nutrients in the composite scaffolds porous structure is practically not affected by their geometric shape.

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Section: Results Of Internal Flow Modelingsupporting

confidence: 85%

A Numerical Study of Fluid Flow in the Porous Structure of Biological Scaffolds

Daulbayev

Mansurov

Sultanov

et al. 2020

Eurasian Chem. Tech. J.

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“…Bone is a piezoelectric tissue; hence, using GOBMs, they supply either essential mechanical and biological requirements or electrical conductivity [ 28 ]. GOBMs, rGO in particular, could enhance levels of biocompatibility, alkaline phosphatase activity, and calcium deposits, which are essential for bone regeneration [ 62 ]. Biphasic calcium phosphate (BCP) coated with rGO (BCP-rGO) at various concentrations was fabricated in a previous study.…”

Section: Development Of Tissues and Organs Using Graphene-based Materialsmentioning

confidence: 99%

Graphene Oxide: Opportunities and Challenges in Biomedicine

et al. 2021

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Desirable carbon allotropes such as graphene oxide (GO) have entered the field with several biomedical applications, owing to their exceptional physicochemical and biological features, including extreme strength, found to be 200 times stronger than steel; remarkable light weight; large surface-to-volume ratio; chemical stability; unparalleled thermal and electrical conductivity; and enhanced cell adhesion, proliferation, and differentiation properties. The presence of functional groups on graphene oxide (GO) enhances further interactions with other molecules. Therefore, recent studies have focused on GO-based materials (GOBMs) rather than graphene. The aim of this research was to highlight the physicochemical and biological properties of GOBMs, especially their significance to biomedical applications. The latest studies of GOBMs in biomedical applications are critically reviewed, and in vitro and preclinical studies are assessed. Furthermore, the challenges likely to be faced and prospective future potential are addressed. GOBMs, a high potential emerging material, will dominate the materials of choice in the repair and development of human organs and medical devices. There is already great interest among academics as well as in pharmaceutical and biomedical industries.

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“…The gel precursor solution could be loaded with cells and growth factors into a syringe, so that, upon injection in vivo, the smart polymer responded to the body temperature by undergoing gelation into a scaffold to sustain neovascularization [ 91 ]. Similarly, the ability of GO to adsorb proteins was used to engineer a fibrin hydrogel for bone regeneration, which was loaded with hydroxyapatite to favor biomineralization, and with iron-oxide nanoparticles to render the system magneto-responsive [ 96 ]. Alternatively, bioactive proteins can be covalently bound to the large surface provided by graphene and stabilized through encapsulation within a hydrogel matrix.…”

Section: Recent Advancements On Hydrogels With Carbon Nanomaterials For Medicinementioning

confidence: 99%

Smart Hydrogels Meet Carbon Nanomaterials for New Frontiers in Medicine

2021

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Carbon nanomaterials include diverse structures and morphologies, such as fullerenes, nano-onions, nanodots, nanodiamonds, nanohorns, nanotubes, and graphene-based materials. They have attracted great interest in medicine for their high innovative potential, owing to their unique electronic and mechanical properties. In this review, we describe the most recent advancements in their inclusion in hydrogels to yield smart systems that can respond to a variety of stimuli. In particular, we focus on graphene and carbon nanotubes, for applications that span from sensing and wearable electronics to drug delivery and tissue engineering.

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Fibrin hydrogel incorporated with graphene oxide functionalized nanocomposite scaffolds for bone repair — In vitro and in vivo study

Cited by 53 publications

References 47 publications

A Numerical Study of Fluid Flow in the Porous Structure of Biological Scaffolds

A Numerical Study of Fluid Flow in the Porous Structure of Biological Scaffolds

Graphene Oxide: Opportunities and Challenges in Biomedicine

Smart Hydrogels Meet Carbon Nanomaterials for New Frontiers in Medicine

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