Fibrin in fibroblast cultures — a metabolic study as a contribution to inflammation and tissue repair

FDG Positron Emission Tomography for Differentiation of Degenerative and Infectious Endplate Abnormalities in the Lumbar Spine Detected on MR Imaging

“…These cell types are characterized by respiratory bursts when activated by inflammatory mediators present in infectious foci, which results in increased glucose metabolism [6,19,28]. The matured fibroblasts that are a typical constituent of granulation tissue [29,30] and therefore potentially found in degeneration do not react with such respiratory bursts. Daley et al [31] found that the cells present after sterile injury were predominantly fibroblasts.…”

Biochemical changes in endothelial cell monolayers induced by fibrin deposition in vitro.

“…Fibroblasts maintained in the presence of fibrin have altered rates of growth, glycosaminoglycan synthesis, and oxygen consumption. 39 Fibrin deposition also alters the production of plasminogen activator by fibroblasts. 40 Fibrin and fibrinogen bind to platelets, 41 macrophages, 42 and fibroblasts.…”