Fibrin Sealing of Fistulas in Crohn’s Disease

Eimiller, A.; Berg, P L; Born, Peter; Barina, W.; Zellmer, R.; Neuhaus, Horst; Paul, F; Homann, H.-H.

doi:10.1007/978-3-642-48362-2_7

Cited by 3 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The development of endoscopic injected therapy, in which a number of various solutions can be injected into the base of the lesions via a catheter with a retractable needle, has been demonstrated in recent years [9,10,11,13]: the injection of fibrin sealant has been used successfully in several trials and case series in patients with bleeding from peptic ulcers of varying degrees of severity [7].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Drug Targets in Colonoscopic Polypectomy: Biological Sealants with Special Reference to Fibrin-Glue (Tissucol)

Venezia¹

2005

curr drug targets immune endocr metabol disord

View full text Add to dashboard Cite

The increasing outpatient use of colonoscopy in the diagnostic study and prophylaxis of colon diseases has allowed early identification of polypoid neoformations, thus indicating their increased incidence during the asymptomatic phase. In this respect, the application of biological sealants immediately before the polypectomy has represented a novel therapeutic strategy in the treatment of these preneoplastic lesions. The injection of biological sealants with needle under the polyp peduncle or sub-mucosa has demonstrated a protective action on the electrocoagulated area, an anti-haemorrhagic effect owing to the strengthened seal of the eschar that is formed, and a facilitated tissue regeneration, respectively. The author report his experience acquired over the past five years with regard to the use of biological sealant in colonoscopic polypectomy and conclude that biological sealants, a human fibrin glue, which utilises components of the human plasma, may allow a more generous removal of neoformations, the absence of post-polypectomy complications and, consequently, the dramatic reduction of time of patient's admission in the hospital. In fact, all patients were discharged after two hours from polypectomy, thus implying a better quality of life for patients, in the absence of post-operative complications and a reduction of non-medical costs.

show abstract

Section: Discussionmentioning

confidence: 99%

“…These antiplasmins are blended inside the clot by the action of factor XIIIa so to operate their function of blockade of the fibrinolysis. This mechanism has as the result of augmenting the formation of the connective tissue [12][13][14][15][16][17][18][19].…”

Section: The Fibrin Glue In Surgery Why?mentioning

confidence: 99%

Drug Targets in Colonoscopic Polypectomy: Biological Sealants with Special Reference to Fibrin-Glue (Tissucol)

Venezia¹

2005

curr drug targets immune endocr metabol disord

View full text Add to dashboard Cite

show abstract

“…Bei kurzstreckiger Stenose ist auch der Versuch einer endoskopischen Dilatation gerechtfertigt [11,18]. In der Literatur wurde zwar auch wiederholt über den Versuch endoskopischer Fistelverklebungen mit Fibrin berichtet [6,18]. B. bei ileocolischen Anastomosenstenosen eine mögliche Therapiealternative dar [2].…”

Section: Therapieunclassified