Fibrinogen–albumin ratio predicting major adverse cardiovascular outcomes post‐percutaneous coronary intervention: A systematic review and exploratory meta‐analysis

Desai, Rupak; Fadah, Kahtan; Srikanth, Sashwath; Neha, N F N; Jain, Akhil

doi:10.1002/clc.23981

Cited by 6 publications

(3 citation statements)

References 11 publications

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“… 8–10 Furthermore, FAR has also been proven to be independently associated with the severity and prognosis of coronary artery disease (CAD). 37 Karahan O et al reported that FAR was strongly related to the severity of CAD in patients with ST-segment elevation myocardial infarction (STEMI). 38 Recently, a large observational study with a 5-year follow-up found that a higher FAR combined with DM was associated with worse 5-year outcomes in patients with CAD undergoing percutaneous coronary intervention (PCI).…”

Section: Discussionmentioning

confidence: 99%

A High Fibrinogen-to-Albumin Ratio on Admission is Associated with Early Neurological Deterioration Following Intravenous Thrombolysis in Patients with Acute Ischemic Stroke

Sun,

Cheng,

et al. 2024

JIR

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Section: Discussionmentioning

confidence: 99%

A High Fibrinogen-to-Albumin Ratio on Admission is Associated with Early Neurological Deterioration Following Intravenous Thrombolysis in Patients with Acute Ischemic Stroke

Sun,

Cheng,

et al. 2024

JIR

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“…It has been proven to be related to the prognosis of infectious disease, malignant tumors, and cardiovascular disease (13)(14)(15). High FAR was associated with adverse cardiovascular outcomes after percutaneous coronary intervention (16). In addition, FAR was related to the progression of gastric cancer and could predict long-term poor prognosis in patients with gastric cancer (17).…”

Section: Introductionmentioning

confidence: 99%

The association between the fibrinogen-to-albumin ratio and delirium after deep brain stimulation surgery in Parkinson’s disease

Lu,

Wang,

Lin

et al. 2024

Front. Med.

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IntroductionPostoperative delirium (POD) remains one of the most prevalent neuropsychiatric complications after deep brain stimulation (DBS) surgery. The fibrinogen-to-albumin ratio (FAR) has been shown to significantly correlate with the prognosis of many diseases related to inflammation. However, the association between FAR and POD remains unclear. We aimed to explore the association between POD and FAR in patients with Parkinson’s disease (PD) undergoing DBS surgery.MethodsPatients with PD who underwent DBS surgery in our hospital were included in this retrospective study. FAR was calculated from the blood sample collected on admission. The association between baseline FAR and delirium after surgery was assessed by binary logistic regression analysis, interaction analysis, and stratified analyses.ResultsOf 226 patients, 37 (16.4%) suffered from delirium after surgery. The average age of the participants was 63.3 ± 7.2 years, and 51.3% were male patients. Multivariate logistic regression analysis indicated that patients in the highest FAR tertile had a higher risk of POD compared with patients in the lowest FAR tertile (OR = 3.93, 95% CI: 1.24 ~ 12.67). Subgroup analysis demonstrated that FAR and the preoperative Mini-Mental State Examination score (p = 0.013) had an association with delirium after surgery.ConclusionOur data suggest that a higher preoperative FAR was significantly associated with delirium after DBS surgery. FAR on admission is a useful candidate biomarker to identify patients with PD who are at a high risk of delirium following DBS surgery.

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“…Albumin deficiency prevents platelet inhibition and leads to inflammatory and oxidative damage. The fibrinogen to albumin ratio (FAR) has been reported to be superior to considering fibrinogen or albumin individually [6,7]. The fibrinogen to CRP ratio (FCR), developed by Kim et al [8], aims to enhance sensitivity by accounting for the physiological changes in fibrinogen, an acute-phase reactant, during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of C‐Reactive Protein (CRP) to Albumin Ratio (CAR) and Fibrinogen to CRP Ratio (FCR) in Predicting the Latent Period of Preterm Labor

Seyhanli,

Bayraktar,

Cakir

et al. 2024

American J Rep Immunol

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ObjectiveTo investigate the role of inflammatory markers, including neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and monocyte to lymphocyte ratio (MLR), c‐reactive protein (CRP) to albumin ratio (CAR), fibrinogen to albumin ratio (FAR), and fibrinogen to CRP ratio (FCR) in predicting the latency period (≤72 vs. >72 hours) before preterm birth.Materials and MethodsIn a retrospective study, we assessed 135 patients meeting the specified criteria with signs of preterm labor (<34 weeks). The patients were categorized into two groups: 71 patients giving birth within 72 h (latency ≤ 72 h) and 64 patients giving birth after 72 h (latency > 72 h). We examined the demographic and medical characteristics and perinatal outcomes of all participants. Categorical variables between groups were compared using the Chi‐square test. The Student's t‐test was utilized for normally distributed continuous variables, and the Mann–Whitney U test was applied for non‐normally distributed data. Receiver operating characteristic (ROC) curve analysis was conducted to identify the optimal cut‐off levels for inflammatory markers in predicting the latency period before birth.ResultsAmong the parameters examined, significant differences were observed between the groups only in terms of CAR and FCR. While CAR showed a significantly higher value in the group with latency period ≤72 h (0.537 ± 1.239 vs. 0.247 ± 0.325, p = 0.022), FCR showed a significantly lower value in the group with latency period ≤72 h (63.58 (2.99–1165) vs. 88.93 (9.35–1165), p = 0.013). The identified cut‐off value for CAR was 0.190, providing a sensitivity of 57.7% and a specificity of 56.3% (p = 0.022). The cut‐off value for FCR was 71.67, with a sensitivity of 42.3% and a specificity of 42.2% (p = 0.013).ConclusionsThe CAR and the FCR, serving as predictive markers for preterm labor, may offer a simple, cost‐effective, and easily accessible approach, particularly in resource‐limited settings.

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Fibrinogen–albumin ratio predicting major adverse cardiovascular outcomes post‐percutaneous coronary intervention: A systematic review and exploratory meta‐analysis

Cited by 6 publications

References 11 publications

A High Fibrinogen-to-Albumin Ratio on Admission is Associated with Early Neurological Deterioration Following Intravenous Thrombolysis in Patients with Acute Ischemic Stroke

A High Fibrinogen-to-Albumin Ratio on Admission is Associated with Early Neurological Deterioration Following Intravenous Thrombolysis in Patients with Acute Ischemic Stroke

The association between the fibrinogen-to-albumin ratio and delirium after deep brain stimulation surgery in Parkinson’s disease

The Efficacy of C‐Reactive Protein (CRP) to Albumin Ratio (CAR) and Fibrinogen to CRP Ratio (FCR) in Predicting the Latent Period of Preterm Labor

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