Fibrinogen and Neutrophil-to-lymphocyte Ratio Predicts Survival in Patients with Advanced Hypopharyngeal Squamous Cell Carcinoma

Kuwahara, Tatsu; Takahashi, Hideaki; Sano, Daisuke; Matsuoka, Masao; Hyakusoku, Hiroshi; Hatano, Takashi; Hiiragi, Yohei

doi:10.21873/anticanres.12859

Cited by 17 publications

(13 citation statements)

References 38 publications

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“…The findings from the present study showed some relationships between peripheral blood hematological and serological parameters, patient demographics, clinicopathologic characteristics, and patient prognosis in LSCC. There have been previous reports that high preoperative plasma levels of fibrinogen correlated with poor patient survival in esophageal squamous cell carcinoma [40,41] and advanced hypopharyngeal squamous cell carcinoma [42]. Pretreatment measurement of the NLR and the platelet-to-lymphocyte ratio (PLR) have been shown to be a useful complement to TNM staging in the prognostic assessment of patients with nasopharyngeal carcinoma (NPC) [43].…”

Section: Discussionmentioning

confidence: 99%

A Retrospective Study of The Prognostic Significance of Preoperative Plasma Fibrinogen, Mean Platelet Volume, and the Neutrophil-to-Lymphocyte Ratio in Patients with Laryngeal Squamous Cell Carcinoma

Sheng

Zhang

et al. 2019

Med Sci Monit

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Background This study aimed to evaluate the prognostic significance of plasma fibrinogen, serum albumin, the mean platelet volume (MPV), and the neutrophil-to-lymphocyte ratio (NLR) in patients with laryngeal squamous cell carcinoma (LSCC) who underwent surgical resection. Material/Methods A retrospective study included 110 patients with LSCC who underwent surgical resection between January 2008 to June 2015. Clinicopathologic and demographic data were recorded. Preoperative levels of plasma fibrinogen, serum albumin, MPV, and NLR were measured, and all patients underwent postoperative follow-up. The Kaplan-Meier method was used to determine the impact of these factors on overall survival (OS) and disease-free survival (DFS). Results Preoperative hyperfibrinogenemia was significantly correlated with clinical stage, T stage, and tumor location in patients with LSCC (P<0.05). Serum albumin, MPV, and NLR were significantly correlated with the clinical stage and the T stage (P<0.05). The OS and DFS were significantly reduced in patients with hyperfibrinogenemia compared with patients with plasma fibrinogen <4 g/dL (P<0.05). Serum albumin of 35 g/L was not significantly correlated with OS (P>0.05). Patients with an MPV <9.5 fL had a significantly longer OS compared with patients with an MPV ≥9.5 fL (P=0.026). The DFS of patients with an NLR <2.22 was significantly longer than for those with an NLR ≥2.22. Conclusions Preoperative hyperfibrinogenemia, increased MPV and NLR were associated with reduced prognosis in patients with LSCC.

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Section: Discussionmentioning

confidence: 99%

A Retrospective Study of The Prognostic Significance of Preoperative Plasma Fibrinogen, Mean Platelet Volume, and the Neutrophil-to-Lymphocyte Ratio in Patients with Laryngeal Squamous Cell Carcinoma

Sheng

Zhang

et al. 2019

Med Sci Monit

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“…Eleven studies were conducted in China, and six in Japan. Five different types of DSCs were assessed in this study, including esophageal carcinoma (EC) ( 4 , 8 , 13 , 17 , 18 ), gastric cancer (GC) ( 5 , 6 , 11 , 14 , 16 , 20 ), colorectal cancer (CRC) ( 10 , 12 , 19 ), hypopharyngeal carcinoma (HPC) ( 9 ), hepatocellular carcinoma (HCC) ( 7 , 15 ). The characteristics of the included studies are summarized in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Recently, a new scoring system, termed fibrinogen and neutrophil-lymphocyte ratio (F-NLR), that combines pretreatment fibrinogen levels with neutrophil-lymphocyte ratio (NLR) has gradually attracted considerable research attention. The F-NLR score has been reported as a promising prognostic marker in patients with DSCs (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). However, the results remain controversial.…”

Section: Original Articlementioning

confidence: 99%

Prognostic value of combined pretreatment fibrinogen and neutrophil-lymphocyte ratio in digestive system cancers: a meta-analysis of 17 retrospective studies

Liu¹,

Dai²,

Zheng³

et al. 2021

Transl Cancer Res TCR

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Background: Several epidemiological studies have reported the relationship between the combined pretreatment fibrinogen and neutrophil-lymphocyte ratio (F-NLR) and prognosis of digestive system cancers (DSCs). However, the results are controversial. We aimed to assess the prognostic value of F-NLR in patients with DSCs.Methods: A comprehensive search for relevant studies was conducted until June, 2020. Studies that evaluated the association of the F-NLR score with survival outcome in patients with any DSCs were included. The hazard ratio (HR) and 95% confidence interval (CI) were calculated using a fixed-effects model. All data analyses were performed using the STATA 12.0 software.Results: A total of 17 studies involving 5,767 participants were included in the meta-analysis. We found that high F-NLR score was significantly associated with poor overall survival (OS) in patients with DSCs (HR =2.0; 95% CI, 1.78-2.24). In addition, patients with high F-NLR score had poor disease-free survival/ progression-free survival/recurrence-free survival (DFS/PFS/RFS) (HR =2.01; 95% CI, 1.47-2.74) and DFS (HR =1.97; 95% CI, 1.35-2.87). Sensitivity analyses for OS confirmed that the results were stable.Conclusions: High F-NLR score is significantly associated with poor prognostic outcomes in patients with DSCs and can serve as an effective prognostic indicator for the Asian population.

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“…Advances in treatment techniques may improve the survival rate; however, risk stratification is also important in developing an individualized treatment management schedule. To date, researchers have made efforts to identify prognostic factors, including clinical features (21), cellular adverse factors (22,23) and molecular markers (24,25). This information can be used to identify patients with high-risk HNSCC who may benefit from more aggressive therapy and frequent follow-up following primary treatment.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of COL1A1 and COL1A2 expression levels in hypopharyngeal squamous cell carcinoma

et al. 2020

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Fibrinogen and Neutrophil-to-lymphocyte Ratio Predicts Survival in Patients with Advanced Hypopharyngeal Squamous Cell Carcinoma

Abstract: F-NLR score was useful to stratify patients to extract poor prognostic characteristics in patients with advanced HPC.

Cited by 17 publications

References 38 publications

A Retrospective Study of The Prognostic Significance of Preoperative Plasma Fibrinogen, Mean Platelet Volume, and the Neutrophil-to-Lymphocyte Ratio in Patients with Laryngeal Squamous Cell Carcinoma

A Retrospective Study of The Prognostic Significance of Preoperative Plasma Fibrinogen, Mean Platelet Volume, and the Neutrophil-to-Lymphocyte Ratio in Patients with Laryngeal Squamous Cell Carcinoma

Prognostic value of combined pretreatment fibrinogen and neutrophil-lymphocyte ratio in digestive system cancers: a meta-analysis of 17 retrospective studies

Clinical significance of COL1A1 and COL1A2 expression levels in hypopharyngeal squamous cell carcinoma

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