Fibrinogen as a Marker of Overall and Complicated Acute Appendicitis: A Systematic Review and Meta-Analysis

Wu, Zhenfei; Zhao, Lingling; Liu, Yujun; Qian, Shuyang; Wu, Lianjun; Liu, Xian

doi:10.1016/j.jss.2022.07.001

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Appendicitis can affect people of any age, and there is no significant difference in the incidence between men and women. Therefore, AA should be diagnosed and treated as early as possible, and once suspected symptoms appear (such as right lower abdominal pain, fever, nausea, vomiting, and loss of appetite), people should seek medical attention to avoid potential complications and harm 9,10 .…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of abdominal ultrasound in patients with acute appendicitis and analysis of the expression of related inflammatory factors.

Yang,

Wang,

Yang

et al. 2024

Investigación Clínica

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Appendicitis is an inflammation of the appendix that, if left un-treated, can be life-threatening. Abdominal ultrasound helps diagnose it and differentiate it from other causes of abdominal pain. This study aimed to evalu-ate the diagnostic value of abdominal ultrasound in acute appendicitis (AA) and assess inflammatory factor levels in different types of appendicitis. One hundred patients with AA were selected as the observation group, and 30 pa-tients with simple abdominal pain as the control group. Among the 100 AA patients, 37 (37%) cases had blurred appendiceal boundaries, 24 (24%) cases had fecal calculus in the appendix cavity, 13 (13%) cases had enhanced echo intensity of surrounding fat, 15 (15%) cases presented enlarged outer diameter of the appendix (> 6mm), one (1%) case had peripheral lymphadenopathy, and one (1%) case had peripheral effusion. None of the cases (0%) presented a pe-ripheral mass. The levels of white blood cells (WBC) and inflammatory factors: C-reactive protein (CRP), interleukin-6 (IL -6), and tumor necrosis factor α(TNF-α)) patients with uncomplicated appendicitis were lower than those with suppurative appendicitis, gangrenous appendicitis, or peri-appendiceal abscess (p <0.05). The blurred boundary of the appendix, fecal stones in the appendix cavity, an enlarged outer diameter of the appendix (> 6mm), and an enhanced echogenicity of the surrounding fat are the most common ultrasonic signs of AA. Abdominal ultrasound has an excellent diagnostic value on pathological types of AA. The increase in the level of inflammatory factors can indicate the severity of the disease to a certain extent.

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Section: Introductionmentioning

confidence: 99%

Diagnostic value of abdominal ultrasound in patients with acute appendicitis and analysis of the expression of related inflammatory factors.

Yang,

Wang,

Yang

et al. 2024

Investigación Clínica

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“…Recent studies used hyperbilirubinemia to differentiate appendicular perforation and acute appendicitis based on serum bilirubin values. most of these studies are retrospective studies and have one or more limitations in their study design, and very limited prospective studies are available on this serum biomarker [5]. Outcomes in different appendicular pathology are variable; patients who are presented with acute appendicitis requiring surgical intervention will have good recovery, but when it comes to patients who are diagnosed with perforated appendix may have life-threatening complications, including the death of the patient [6,7].…”

Section: Introductionmentioning

confidence: 99%

Correlational study of Hyperbilirubinemia as a diagnostic predictor for perforation in acute appendicitis

Papanaidu,

Chinta

2024

JAPR

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Background: Appendicitis is an acute and life-threatening situation if not treated promptly encountered in surgery practice. Even today, most cases of appendicitis are diagnosed by clinical findings and imaging. Scanty information is available to diagnose the perforation of the appendix using serological tests; hence, an attempt is made. The present study aimed to find out the correlation of hyperbilirubinemia as a diagnostic predictor for perforation in acute appendicitis patients. Methods: This prospective observational study was conducted among patients diagnosed with acute appendicitis attending OPD of the general surgery department of Narayana Medical College Hospital. The duration of the study is between January 2023 and December 2023. A total of 400 patients with a diagnosis of either acute appendicitis or perforation were recruited into the study, and they collected blood samples for estimation of hyperbilirubinemia. Results: In the study population of 400 patients, 72 cases were diagnosed as appendicular perforation, and 328 patients had acute appendicitis. The cut-off value of hyperbilirubinemia was taken as serum bilirubin >1.0 mg/dl. Out of 72 cases of appendicular perforations, 64 patients have hyperbilirubinemia (89%), while in the acute appendicitis patients group, 82 of 328 patients have elevated serum bilirubin (25%). The observed mean values of serum bilirubin in the two groups were 1.74 and 0.89, and the difference in the standard error of the mean value of the two groups is statistically significant at a P-value of <0.001. Conclusions: Patients who presented with acute appendicitis symptoms and had serum bilirubin values >1.0 mg/dl had a higher probability of appendicular perforation. Hence, measuring serum bilirubin can be considered an additional diagnostic tool to existing clinical diagnosis and radiological evaluation for more precision in diagnosis.

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“…It is most often seen in patients between 10 and 30 years old (2) . If neglected, AA ultimately complicates (20-30%), leading to gangrene, perforation, local peritonitis, or diffuse peritonitis, among other potentially serious problems (3)(4)(5)(6)(7) . The diagnosis of complicated acute appendicitis (CAA) is primarily built on a combination of clinical suspicion of AA progression of severity, inflammatory laboratory blood markers, and pelviabdominal imaging such as ultrasonography (US) and computed tomography (CT) (6)(7)(8)(9) .…”

Section: Introductionmentioning

confidence: 99%

Management of Complicated Acute Appendicitis in Adults: Laparoscopic versus Open Appendectomy

Baz¹,

Orban²,

Heggy³

2023

The Egyptian Journal of Hospital Medicine

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Background: Nowadays laparoscopic appendectomy (LA) is the management of choice for acute appendicitis (AA) in simple, uncomplicated cases. For complicated acute appendicitis (CAA), laparoscopic or conventional open appendectomy (OA) is still in debate.Objective: This study aimed to compare minimally invasive LA and traditional OA in CAA cases. Methods: In this study, 44 patients with CAA (22 for LA and 22 for OA) with 18 years of age or older were enrolled. It was conducted in General Surgery Department, Helwan University Hospital. Results:The operative time difference between the LA and OA groups was statistically significant (18.5 minutes shorter in the OA group, (p<0.001). The median length of hospital stay, return to normal activity, and patient satisfaction were significantly better in the LA group (p-values of 0.001, 0.00, and 0.14 respectively). The need for analgesics in the LA group was significantly lower than in the OA group. There were no detectable statistically significant findings concerning the occurrence of surgical findings, postoperative vomiting, postoperative ileus, wound infection, wound dehiscence, or postoperative intra-abdominal collection. Conclusions: Laparoscopic appendectomy management of CAA is feasible, safe, and has numerous advantages over the traditional open procedure in terms of reducing postoperative pain, requiring fewer analgesics, shortening the postoperative hospital stay, having a low incidence of postoperative infectious complications, and allowing a rapid return to daily activities with improved comfort and satisfaction.

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Fibrinogen as a Marker of Overall and Complicated Acute Appendicitis: A Systematic Review and Meta-Analysis

Cited by 3 publications

References 17 publications

Diagnostic value of abdominal ultrasound in patients with acute appendicitis and analysis of the expression of related inflammatory factors.

Diagnostic value of abdominal ultrasound in patients with acute appendicitis and analysis of the expression of related inflammatory factors.

Correlational study of Hyperbilirubinemia as a diagnostic predictor for perforation in acute appendicitis

Management of Complicated Acute Appendicitis in Adults: Laparoscopic versus Open Appendectomy

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