Fibrinogen Assays for Cardiovascular Risk Assessment

Lowe, G. D. O.

doi:10.1373/clinchem.2010.145342

Cited by 17 publications

(12 citation statements)

References 13 publications

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“…Finally, fibrinogen is a blood plasma protein that is made in the liver. It is also an acute phase reactant, and levels rise when inflammation is present . Unfavorable levels of these three inflammatory biomarkers have been found to be associated with several physical and mental health conditions …”

Section: Introductionmentioning

confidence: 99%

“…It is also an acute phase reactant, and levels rise when inflammation is present. 16 Unfavorable levels of these three inflammatory biomarkers have been found to be associated with several physical and mental health conditions. [17][18][19] Inflammatory processes have also been linked with muscle atrophy (and thus weaker grip strength), 20 and muscle tissue expresses various transcriptional co-activators that may promote systemic anti-inflammatory effects.…”

Section: Introductionmentioning

confidence: 99%

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Handgrip strength, inflammatory markers, and mortality

Smıth

Yang

Hamer

2019

Scandinavian Med Sci Sports

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Purpose To investigate the extent to which inflammatory markers explain the association between handgrip strength and mortality. Methods Analyses of data from The English Longitudinal Study of Ageing. Handgrip strength and inflammatory marker data (C‐reactive protein and fibrinogen) were collected at baseline (2004/5) and inflammatory marker data at follow‐up (2012/13). Participant data were linked with death records. General linear models were used to explore associations between handgrip strength and inflammatory markers at follow‐up. Cox proportional hazards regression models were used to examine associations between grip strength and risk of death. Models were estimated with the covariates age, sex, wealth, physical activity, smoking, depressive symptoms, long‐standing illness, and adiposity. Results The sample comprised of 5,240 participants (mean age 65.9 (SD 9.4) years; 53.8% female). Over an average 9.7 ± 1.4 years follow‐up, there were 650 deaths. Inverse associations were evident between handgrip strength and change in inflammatory markers in women only. There was an association between grip strength and lower risk of mortality in women (hazard ratio = 0.85; 95% CI, 0.74, 0.98) after adjusting for age and wealth. The association was attenuated after adjustment for clinical and behavioral risk factors (0.92; 0.79, 1.07), and further attenuated after adjusting for inflammatory markers (0.95; 0.82, 1.11). Conclusion Higher grip strength is associated with lower levels of inflammation at 8‐year follow‐up, and inflammatory markers partly explained the association between handgrip strength and mortality.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Handgrip strength, inflammatory markers, and mortality

Smıth

Yang

Hamer

2019

Scandinavian Med Sci Sports

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“…Fibrinogen is the precursor of fibrin, which plays a fundamental role in homeostasis and mediator of platelet aggregation . Relationships between plasma fibrinogen and cardiovascular disease risk have been reported by several earlier studies . Moreover, fibrinogen could also play a crucial role in endothelial function, thrombosis, and inflammation .…”

Section: Introductionmentioning

confidence: 99%

Neopterin: An immune biomarker of coronary artery disease and its association with other CAD markers

et al. 2015

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Neopterin has been considered as an important marker of cellular inflammation. The primary objective of the current study was to determine the role of neopterin in cardiovascular disease and its association with other well known cardiac markers. The study was composed of total 200 subjects (100 confirmed coronary artery disease (CAD) patients, 50 recently diagnosed, and 50 managed CAD patients) both men and women and 100 healthy control individuals of matching age and weight. Serum neopterin analysis was done using commercial available ELISA kits. Other cardiac markers viz. troponin, creatine kinase (CK), CK MB isoenzyme (CKMB), lactate dehydrogenase (LDH), fibrinogen, C-reactive protein (CRP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) estimation was done by standard routine biochemical methods. Neopterin level was found to be remarkably enhanced by 150% and 513% in the recently diagnosed and managed CAD patients, respectively. CK level also showed a significant rise by 62% in the managed patients. However, recently diagnosed patients did not show any significant change. Moreover, cross correlation study showed statistically significant (P < 0.01) change in neopterin and CK levels between recently and managed patients. In the other studied CAD markers such as CKMB, fibrinogen and LDH also showed a significant increase in both categories of patients. CRP level was also found to be significantly enhanced by 357% (P < 0.01) and 341% (P < 0.05) in recently diagnosed and managed patients respectively. Because of cost effectiveness, easy and quick analysis of neopterin in the serum sample, we propose neopterin as the prognostic as well as diagnostic biomarker of CAD before other markers could be tested especially in Saudi population.

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“…In clinical pathological states, plasma levels of fibrinogen correlates well with the prognosis of patients including cardiovascular (12) and non-cardiovascular diseases (13), and has been accepted as a biochemical marker for the patient prognosis. Still unanswered question, however, is whether fibrinogen serves as the causative pathological protein or just an auxiliary inflammatory marker.…”

Section: Introductionmentioning

confidence: 99%

Role of Elevated Fibrinogen in Burn-Induced Mitochondrial Dysfunction

Ueki

Liu

Kashiwagi

et al. 2016

Shock

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Introduction Skeletal muscle wasting and weakness with mitochondrial dysfunction (MD) are major pathological problems in burn injury (BI) patients. Fibrinogen levels elevated in plasma is an accepted risk factor for poor prognosis in many human diseases, and is also designated one of damage-associated molecular pattern (DAMPs) protein. The roles of upregulated fibrinogen on muscle changes of critical illness including BI are unknown. The hypothesis tested was that BI-upregulated fibrinogen plays a pivotal role in the inflammatory responses and MD in muscles, and that DAMPs inhibitor, glycyrrhizin mitigates the muscle changes. Methods After third degree BI to mice, fibrinogen levels in the plasma and at skeletal muscles were compared between BI and sham-burn (SB) mice. Fibrinogen effects on inflammatory responses and mitochondrial membrane potential (MMP) loss were analyzed in C2C12 myotubes. In addition to survival, the anti-inflammatory and mitochondrial protective effects of glycyrrhizin were tested using in vivo microscopy of skeletal muscles of BI and SB mice. Results Fibrinogen in plasma and its extravasation to muscles significantly increased in BI versus SB mice. Fibrinogen applied to myotubes evoked inflammatory responses (increased MCP-1 and TNF-α; 32.6 and 3.9 fold, respectively) and reduced MMP; these changes were ameliorated by glycyrrhizin treatment. In vivo MMP loss and superoxide production in skeletal muscles of BI mice were significantly attenuated by glycyrrhizin treatment, together with improvement of BI survival rate. Conclusions Inflammatory responses and MMP loss in myotubes induced by fibrinogen were reversed by glycyrrhizin. . Anti-inflammatory and mitochondrial protective effect of glycyrrhizin in vivo leads to amelioration of muscle MD and improvement of BI survival rate.

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Fibrinogen Assays for Cardiovascular Risk Assessment

Cited by 17 publications

References 13 publications

Handgrip strength, inflammatory markers, and mortality

Handgrip strength, inflammatory markers, and mortality

Neopterin: An immune biomarker of coronary artery disease and its association with other CAD markers

Role of Elevated Fibrinogen in Burn-Induced Mitochondrial Dysfunction

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