Fibrinogen Concentration and Factor VIII Activity in Women with Preeclampsia

Williams, Vaughan; Griffiths, Adrian; Carbone, Sarah; Hague, William

doi:10.1080/10641950701548240

Cited by 22 publications

(13 citation statements)

References 20 publications

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“…We have also shown that the distribution of HRG in placental tissue is altered in early-but not in late-onset preeclampsia. This study supports earlier findings that pregnancy alters the balance of the coagulation system and that this imbalance is even more pronounced when the pregnancy is complicated by preeclampsia (8,9).…”

Section: Discussionsupporting

confidence: 92%

“…These thrombi are especially prevalent in the preeclamptic placenta. It has been shown that early‐onset preeclampsia is associated with a hypercoagulable state (8) and a disturbed fibrinolytic system. Additionally, women with severe early‐onset preeclampsia display increased D‐dimer levels as compared to women with normal pregnancy (9).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Fibrinogen and histidine‐rich glycoprotein in early‐onset preeclampsia

Kårehed

Wikström

Olsson

et al. 2010

Acta Obstet Gynecol Scand

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Fibrinogen and histidine‐rich glycoprotein in early‐onset preeclampsia

Kårehed

Wikström

Olsson

et al. 2010

Acta Obstet Gynecol Scand

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“…We did not detect any difference in fibrinogen in women who later developed CH, though preeclampsia is known to be a hypercoagulable state, primarily due to increases in thrombin and markers of thrombin activity, [9, 19, 20]. Fibrinogen has been reported to be higher in women with PE, and has been shown to correlate with severity of disease [21, 22]. Our evaluation of fibrinogen was before the onset of clinical disease in women who developed term PE, rather than more severe, early onset, forms of preeclampsia.…”

Section: Discussionmentioning

confidence: 95%

Coagulation and fibrinolytic system protein profiles in women with normal pregnancies and pregnancies complicated by hypertension

Hale

Sobel

Benvenuto

et al. 2012

Pregnancy Hypertension: An International Journal of Women's Car

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Objective The current study longitudinally evaluated concentrations of fibrinogen (Fib), D-Dimer, plasminogen activator type-1 (PAI-1) and tissue type plasminogen activator (T-Pa) before pregnancy and in the first and third trimesters of pregnancy with a focus on the pregnancy transition. Study design Twenty healthy, nonsmoking, nulliparous women, aged 29.8 ± 3.0 years, BMI 23.3 ± 3.2 kg/m2 were studied during menstrual cycle day 8 ± 4 and again in early (11 – 15 wks) and late (31 – 34 wks) pregnancy. Seventeen women had singleton conceptions and delivered at term with uncomplicated pregnancies (CTL) and three women developed complicated hypertension (CH) during pregnancy after the third trimester (late pregnancy) evaluation. Data are means ± SEM, Significance was based on p < 0.05. Results Fib was the only protein evaluated that increased in early pregnancy relative to the prepregnancy assessment. D-dimer, PAI-1 and T-Pa increased in the third trimester compared with prepregnant and early pregnant values (p < .001). T-PA was significantly higher during late pregnancy in CH subjects compared with CTL (8.1 ± 0.7 ng/ml vs. 5.0 ± 0.2 ng/ml, p = .02). There were no other differences between groups. Conclusions Increases in fibrinogen are evident in early pregnancy whereas fibrinolysis, perhaps in response to the procoagulant environment of pregnancy, is increased during late pregnancy. Before development of clinically overt hypertension, T-Pa is increased without concomitant changes in other proteins assessed. This is consistent with altered endothelial function with preeclampsia that may contribute to, or reflect, the vasculopathy accompanying this disorder.

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“…All of the above-mentioned pathways are reported to contribute to the pathogenesis of preeclampsia (45). Circulating levels of total fibrinogen increase 2-fold during the course of a healthy pregnancy (46) and are significantly increased in preeclampsia (7,47), providing a link with the hypercoagulable states of pregnancy and with preeclampsia in particular. Moreover, increased fibrinogen levels have been linked to an increased risk of coronary artery disease (48).…”

Section: Discussionmentioning

confidence: 99%

An altered pattern of circulating apolipoprotein E3 isoforms is implicated in preeclampsia

Atkinson

Blumenstein

Black³

et al. 2009

Journal of Lipid Research

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Preeclampsia is a common pregnancy complication that is an important cause of preterm birth and fetal growth restriction. Because there is no diagnostic test yet available for preeclampsia, we used a proteomic approach to identify novel serum/plasma biomarkers for this condition. We conducted case control studies comparing nulliparous women who developed preeclampsia at 36-38 weeks of gestation with healthy nulliparous women matched by gestational age at sampling. Serum/plasma was depleted of six abundant proteins and analyzed by two-dimensional gel electrophoresis (n 5 12 per group) and difference gel electrophoresis (n 5 12 per group). Differences in abundance of protein spots were detected by univariate and multivariate statistical analyses. Proteins were identified by mass spectrometry and expression of selected proteins was validated by immunoblotting. Proteins whose concentrations were selectively associated with preeclampsia included apolipoprotein E (apoE), apoC-II, complement factor C3c, fibrinogen, transthyretin, and complement factor H-related protein 2. An increase in a deglycosylated isoform of apoE3 and concomitantly decreased amounts of one apoE3 glycoisoform were identified in preeclamptic plasma and confirmed by immunoblotting. Altered production of these preeclampsia-related apoE3 isoforms might impair reverse cholesterol transport, contributing to arterial damage. These findings point to a novel mechanistic link between preeclampsia and subsequent cardiovascular disease.

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Fibrinogen Concentration and Factor VIII Activity in Women with Preeclampsia

Cited by 22 publications

References 20 publications

Fibrinogen and histidine‐rich glycoprotein in early‐onset preeclampsia

Fibrinogen and histidine‐rich glycoprotein in early‐onset preeclampsia

Coagulation and fibrinolytic system protein profiles in women with normal pregnancies and pregnancies complicated by hypertension

An altered pattern of circulating apolipoprotein E3 isoforms is implicated in preeclampsia

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