2010
DOI: 10.2169/internalmedicine.49.3770
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Fibrinogen/Fibrin Degradation Products in Acute Aortic Dissection

Abstract: Background The elevated D-dimer value is one of the clues used to diagnose acute aortic dissection (AAD), but the rapid D-dimer assay is not used at all emergency hospitals. The fibrinogen/fibrin degradation products (FDP) value is also an indicator of enhanced fibrinolysis and may therefore be a useful marker in patients with AAD. In addition, the association between FDP values and partial thrombosis of the false lumen is not elucidated. Patients The present study enrolled 50 patients (66.5±11.2 years of age;… Show more

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Cited by 27 publications
(25 citation statements)
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“…The D‐dimer concentrations were highest in our patients with a partially thrombosed FL, regardless of the extent of dissection. Nagaoka et al32 reported an elevated fibrinogen degradation products concentration in patients with acute type B aortic dissection and a partially thrombosed FL (n=14; median, 18.8 μg/mL) in comparison to that in similar patients with a patent or thrombosed FL (n=21; median, 5.5 μg/mL) ( P =0.01). Thrombogenicity of a partially thrombosed FL, in comparison to that of a patent FL, may be greater, and fibrinolytic activity may thus be markedly enhanced 32…”
Section: Discussionmentioning
confidence: 96%
“…The D‐dimer concentrations were highest in our patients with a partially thrombosed FL, regardless of the extent of dissection. Nagaoka et al32 reported an elevated fibrinogen degradation products concentration in patients with acute type B aortic dissection and a partially thrombosed FL (n=14; median, 18.8 μg/mL) in comparison to that in similar patients with a patent or thrombosed FL (n=21; median, 5.5 μg/mL) ( P =0.01). Thrombogenicity of a partially thrombosed FL, in comparison to that of a patent FL, may be greater, and fibrinolytic activity may thus be markedly enhanced 32…”
Section: Discussionmentioning
confidence: 96%
“…In parallel, plasmin is also involved in dissecting pathology. In particular, circulating plasmin–antiplasmin complex and fibrin degradation product have been proposed as markers of acute dissection, but this is probably due to the fibrinolysis of the clot in the false channel 20. Nevertheless, the participation of tissue plasmin is not excluded.…”
Section: Molecular Biologymentioning
confidence: 99%
“…As to false lumen condition, there had controversy result. For FDP, Hagiwara et al reported a significantly higher level in patients with patent false lumen than thrombosed, while opposite result was showed in study of Nagaoka et al (6,7). The lower value of D-dimer and FDP may be caused by the combined effect of those factors.…”
mentioning
confidence: 90%