Fibrinogen-induced Vitreous Membranes

Mansour, Ahmad M.; Chess, Jeremy; Henkind, Paul

doi:10.1159/000265489

Cited by 9 publications

(7 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These observations appear to corroborate and extend the findings from the EDCCS. In an animal model, fibrinogen induced the formation of vitreous membranes when injected into the vitreous [ 22 ]. Fibrinogen may be transformed into a long fibrin polymer that forms a matrix that allows surrounding cells to proliferate in the vitreous [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

A proteomic approach to understanding the pathogenesis of idiopathic macular hole formation

et al. 2017

View full text Add to dashboard Cite

Idiopathic macular holes (IMH) are full-thickness defects of retinal tissue that cause severe vision loss due to disruption of the anatomic fovea. Abnormal vitreous traction is involved in the formation of macular holes. Both glial cells and hyalocytes contribute to epiretinal membrane formation in IMH. In order to gain further insight into the pathophysiology of IMH, we conducted a discovery phase investigation of the vitreous proteome in four patients with macular holes and six controls using one-dimensional gel fractionation and liquid chromatography–tandem mass spectrometry analyses on an Orbitrap Elite mass spectrometer. Of a total of 5912 vitreous proteins, 32 proteins had increased and 39 proteins had decreased expression in IMH compared with controls, using a false discovery rate approach with p value < 0.001 and q value < 0.05. IMH was associated with increased expression of proteins in the complement pathway, α-2-macroglobulin, a major inducer of Müller glial cell migration, fibrinogen, and extracellular matrix proteins, and decreased expression of proteins involved in protein folding and actin filament binding. A proteomic approach revealed proteins and biological pathways that may be involved in the pathogenesis of IMH and could be targeted for future studies.Electronic supplementary materialThe online version of this article (10.1186/s12014-017-9172-y) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

A proteomic approach to understanding the pathogenesis of idiopathic macular hole formation

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Of these proteins, fibrinogen A was the most highly expressed protein in the vitreous compared to the aqueous fluid. Fibrinogen has been implicated in the development of vitreous membrane formation in a rat model [33]. The other 7 proteins have not been reported to play a role in iERM formation.…”

Section: Cytokines and Growth Factorsmentioning

confidence: 99%

Inflammatory Mechanisms of Idiopathic Epiretinal Membrane Formation

Joshi

Agrawal

Christoforidis

2013

Mediators of Inflammation

109

View full text Add to dashboard Cite

The pathogenesis of idiopathic epiretinal membranes (iERMs), a common pathology found in retina clinics, still eludes researchers to date. Ultrastructural studies of iERMs in the past have failed to identify the cells of origin due to the striking morphologic changes of cells involved via transdifferentiation. Thus, immunohistochemical techniques that stain for the cytostructural components of cells have confirmed the importance of glial cells and hyalocytes in iERM formation. The cellular constituents of iERMs are thought to consist of glial cells, fibroblasts, hyalocytes, etc. that, in concert with cytokines and growth factors present in the vitreous, lead to iERM formation. Recently, research has focused on the role of the posterior hyaloid in iERM formation and contraction, particularly the process of anomalous PVD as it relates to iERM formation. Recent advances in proteomics techniques have also elucidated the growth factors and cytokines involved in iERM formation, most notably nerve growth factor, glial cell line-derived growth factor, and transforming growth factor β1.

show abstract

“…Specific binding with collagen type IV is an additional significant observation 12. Of note, intraocular fibrinogen injection induces vitreous membrane formation in rabbits 13. Taken together, these findings could support the following hypothesis: The progress of retinal detachment causes elevation of the FPL.…”

Section: Discussionmentioning

confidence: 63%

Fibrinogen and rhegmatogenous retinal detachment: a pilot prospective study

Theocharis¹

2010

OPTH

View full text Add to dashboard Cite

Purpose:To examine the correlation, if any, between fibrinogen plasma levels (FPL) and the clinical features of rhegmatogenous retinal detachment (RRD).Methods:FPL were measured preoperatively in 33 patients with primary RRD. Patient characteristics and detachment features such as the numbers of breaks and the extent of the detachment were recorded;Results:No statistically significant correlation was found between FPL and the number of breaks. A statistically significant correlation was found between FPL and the extent of the RRD, even if the influence of the number of breaks was excluded.Conclusions:FPL correlate with retinal detachment extent, which implicates an acute inflammatory response to detachment traumatic phenomenon or a role of the fibrinogen molecule in retinal adhesiveness.

show abstract

Fibrinogen-induced Vitreous Membranes

Cited by 9 publications

References 14 publications

A proteomic approach to understanding the pathogenesis of idiopathic macular hole formation

A proteomic approach to understanding the pathogenesis of idiopathic macular hole formation

Inflammatory Mechanisms of Idiopathic Epiretinal Membrane Formation

Fibrinogen and rhegmatogenous retinal detachment: a pilot prospective study

Contact Info

Product

Resources

About