Fibrinolysis and Alimentary Lipaemia in Whites and Bantus; Their Relationship and Response to Intravenous Heparin

Abstract

Summary and Conclusion1. Diurnal variation in fibrinolysis is marked in the Whites and almost absent in the Bantu. >2. The difference in fibrinolytic activity beween White and Bantu has been confirmed, but was found to decrease over the course of the morning due to diurnal variation in the White subjects.3. The ingestion of butter fat does not inhibit fibrinolysis to any appreciable extent in either White or Bantu.4. The accelerating effect of heparin on fibrinolysis was found to be present in lipaemic plasma, but appears to be distinct from the fat-clearing effect.

Lipoproteins and Fibrinolysis

“…We have found that in normal healthy people alimentary lipemia due to ingestion of saturated fat has no effect upon euglobulin lysis time and therefore no effect upon plasminogen activation. This is in agreement with the work of Buckell & Elliot (1959) and Lackner & Sougin-Mibashan (1961), and Gajewski (1961), although the latter did find that euglobulin lysis time was prolonged during lipemia in men known to have severe atherosclerosis. Further investigation into the effect of alimentary lipemia upon the release of activator from endothelium shows that the increased release occurring in response to local ischlemia remains unmodified by the ingestion of saturated fat (Hawkey, Howell & Lansdown 1964, in preparation).…”

“…Some subsequent workers using similar techniques have agreed with this (Billimoria et al 1959, Farquhar et al 1961). Hougie & Ayers (1960), however, using a technique very similar to Greig's, were unable to demonstrate that lipcmia due to the ingestion of saturated fat had any effect upon fibrinolytic activity of plasma samples: and other workers have shown similar results (Lackner & Sougin-Mibashan 1961, Walker 1961, Ogston & Fullerton 1962.…”