Fibrinolysis and Obesity: The Effect of Weight Reduction

Grace, C. S.

doi:10.1111/imj.1969.18.1.32

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…This is in contrast to the findings o f several workers [1][2][3][4][5][6][7] who found decreased fibrinolytic activity in overweight individuals. One explanation of this discrepancy may be that the subjects included in the present study were all young (19-24 years of age) and healthy, whereas in the other reported series the age varied between 19-78 years with a mean in the range o f 40-50 years.…”

Section: Discussioncontrasting

confidence: 99%

Blood Fibrinolytic Activity in Young Britons, Africans and Asians in Relation to their <sup>‘</sup>Weight-for-Height’ Standard

Is¹

1970

J Vasc Res

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The blood fibrinolytic activity was studied in 93 volunteers belonging to 3 different racial groups and related to their body weight adjusted to the ‘weight-for-height’ standard. No difference was found in this activity when overweight, underweight and standard weight British and Asian males were compared. Increased blood fibrinolytic activity was observed in overweight African Negroes as compared to those of standard weight, and decreased blood fibrinolytic activity was discovered in underweight British women when compared to those of standard weight or overweight. It is suggested that the increased fibrinolytic activity in overweight African males may be due to their increased muscular bulk, since muscles are a potent contributor of plasminogen activator to the circulation.

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Section: Discussioncontrasting

confidence: 99%

Blood Fibrinolytic Activity in Young Britons, Africans and Asians in Relation to their <sup>‘</sup>Weight-for-Height’ Standard

Is¹

1970

J Vasc Res

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“…Weight reduction is known to be associated with a rise in fibrinolytic activity (Grace, 1969), and lest this might be responsible for changes in plasma fibrinolytic activity, the patients' weights were followed. No signscant difference was found between Groups A, B and C either before or during the first 6 mth of treatment and no patient described loss of appetite while on treatment with phenformin.…”

Section: Discussionmentioning

confidence: 99%

Fibrinolytic Enhancement by Stanozolol: A Double Blind Trial

et al. 1972

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Summary Thirty‐four men with ischaemic heart disease were given 10 mg stanozolol per day, 10 mg stanozolol plus 100 mg phenformin per day, or a placebo for 12 mth, in a double blind randomized study. A panel of fibrinolytic and coagulation tests was performed at monthly intervals. Throughout the study the groups on active treatment showed significant enhancement of plasma fibrinolytic activity compared with their base‐line values, and compared with the placebo group. No significant difference was found in the enhancement of fibrinolysis wliich was produced by either active treatment regimens, and it is concluded that 10 mg stanozolol daily‐is as effective as 10 mg stanozolol plus 100 mg phenformin daily in increasing plasma fibrinolytic activity in men with ischaemic heart disease.

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“…It has been reported that an increase in fibrinolytic activity occurs during weight reduction in the obese [4,13], and that short-term negative calorie balance also causes the fibrinolytic activity to increase in persons of normal body build [13], We report a study on the fibrinolytic enzyme system in patients with anorexia nervosa to determine whether chronic negative calorie balance is associated with a sustained increase in fibrinolytic activity and whether it results in alterations in the other components of the fibrinolytic system. …”

mentioning

confidence: 95%