Fibrinolysis: Biochemistry, Clinical Aspects, and Therapeutic Potential

Kwaan, Hau C.; Lisman, Ton; Medcalf, Robert L.

doi:10.1055/s-0036-1598000

Cited by 17 publications

(2 citation statements)

References 10 publications

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“…This activation is driven by tissue Plasminogen Activator (tPA) or urokinase Plasminogen Activator (uPA), the former being released by endothelial cells (specifically, the damaged endothelium of a blood vessel). Both tPA and uPA are regulated by the presence of plasminogen activator inhibitors PAI-I and PAI-2, maintaining the balance that is critical to the hemostatic system [14].…”

Section: Hemostasis and The Hemostatic Systemmentioning

confidence: 99%

Anticoagulants and the Hemostatic System: A Primer for Occupational Stress Researchers

Arble

Arnetz

2021

IJERPH

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Anticoagulation, the body’s mechanism to prevent blood clotting, is an internal biomarker of an individual’s response to stress. Research has indicated that understanding the causes, processes, and consequences of anticoagulation can provide important insight into the experience of individuals facing emotional and occupational strain. Unfortunately, despite their importance, the mechanisms and implications of anticoagulation are unfamiliar to many researchers and practitioners working with trauma-exposed professionals. This paper provides an accessible primer on the topic of anticoagulation, including an overview of the biological process, the research connecting these processes with emotional and occupational functioning, as well as some potential methods for assessment.

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Section: Hemostasis and The Hemostatic Systemmentioning

confidence: 99%

Anticoagulants and the Hemostatic System: A Primer for Occupational Stress Researchers

Arble

Arnetz

2021

IJERPH

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“…Plasmin role is in tissue homeostasis and another role is in acts as modulator of immune response [11]. Cardiovascular diseases (CVDs) is a leading cause of death.…”

Section: Introductionmentioning

confidence: 99%

Fibrinolytic Enzyme: Restoration Tool for Obliteration of Blood Clots

Ashraf¹,

Meer²,

Naz³

et al. 2017

J Mol Imaging Dynam

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Body interrelated complex system maintain body hemostasis but severe vascular injury reprehensible for thrombus formation. Fibrinogen is a prime protein in fibrinolysis. Complex cascade pathway involves in conversion of plasminogen to plasmin to perform fibrinolysis and plasminogen activating inhibitor (PAI) cease this pathway. The genetic and acquired factors influence clot formation while it curbs by factor VIII. This review aims to illustrate significance of fibrinolytic enzymes, Nattokinase, Urokinase, Staphylokinase and streptokinase as therapeutic agent to control myocardial infraction, venous stroke and pulmonary clotting.

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Overview of Hemostasis and Thrombosis and Contribution of Laboratory Testing to Diagnosis and Management of Hemostasis and Thrombosis Disorders

Bonar

Lippi

Favaloro

2017

Methods in Molecular Biology

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Hemostasis is a complex and tightly regulated process whereby the body attempts to maintain a homeostatic balance to permit normal blood flow, without bleeding or thrombosis. When this balance is disrupted, due to trauma or underlying congenital bleeding or thrombotic disorders, clinical intervention may be required. To assist clinicians in diagnosing and managing affected patients, hemostasis laboratories offer an arsenal of tests, both routine (screening) and more specialized (diagnostic). In general, screening assays are used to screen for hemostasis-related disease or to monitor or measure the effect of anticoagulant therapy, which may be applied to treat patients with recent thrombosis or at risk of thrombosis. Diagnostic assays are used to diagnose or exclude specific hemostasis-related diseases, and in some cases, to monitor or measure the effect of anticoagulant therapy, or alternatively procoagulant therapy that may be applied to those at risk of bleeding. This chapter provides an overview of hemostasis and thrombosis with respect to laboratory tests that may be applied to affected patients.

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Fibrinolysis: Biochemistry, Clinical Aspects, and Therapeutic Potential

Cited by 17 publications

References 10 publications

Anticoagulants and the Hemostatic System: A Primer for Occupational Stress Researchers

Anticoagulants and the Hemostatic System: A Primer for Occupational Stress Researchers

Fibrinolytic Enzyme: Restoration Tool for Obliteration of Blood Clots

Overview of Hemostasis and Thrombosis and Contribution of Laboratory Testing to Diagnosis and Management of Hemostasis and Thrombosis Disorders

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