Fibrinolysis Estimated by the Plasminogen/Antiplasmin Ratio in Diabetic Patients

Abnormal coagulation and enhanced fibrinolysis due to lysinuric protein intolerance associates with bleeds and renal impairment

“…Our in vitro coagulation assays revealed reduced ETP and prolonged CT. ETP displays thrombin predominantly generated after clot formation, and the clots formed by low concentrations of thrombin are less resistant to fibrinolysis . Elevated plasminogen/α2‐antiplasmin ratio even further promotes fibrinolysis, as evidenced by shortened CLT in fibrin generation‐clot lysis test. We conclude that impaired primary haemostasis and minor consumption coagulopathy together with enhanced fibrinolysis may explain the bleeding tendency associated with LPI.…”