Fibrinolysis in Cholestatic Jaundice

Jedrychowski, A; Hillenbrand, Peter; Ajdukiewicz, A.B.; Parbhoo, S. P.; Sherlock, Sheila

doi:10.1136/bmj.1.5854.640

Cited by 22 publications

(8 citation statements)

References 16 publications

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“…Our results agree with those of Jedrychowski et al [6] with respect to the finding of reduced fibrinolytic activity and increased fibrinogen levels in patients with primary biliary cirrhosis, but we were unable to detect any relationship between activator activity and serum bilirubin or alkaline phosphatase as indices of cholestasis.…”

Section: Discussionsupporting

confidence: 74%

“…There is abundant evidence that many patients with cirrhosis of the liver have increased plasminogen activator levels and decreased plasminogen con centrations, possibly due to impaired clearance of activator by the liver [4]. A few studies have pointed to changes in the fibrinolytic enzyme sys tem in other forms of hepatic disease: decreased fibrinolytic activity has been reported both in patients with cholestatic jaundice [6] and in pa tients with hepatic metastases [12].…”

mentioning

confidence: 99%

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The Fibrinolytic Enzyme System in Acute and Chronic Liver Injury

Mowat¹,

Brunt²,

Ogston³

1974

Acta Haematol

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Components of the fibrinolytic enzyme system were measured in patients with liver disease. Patients with hepatic cirrhosis and chronic active hepatitis had a trend towards increased plasminogen activator activity and decreased plasminogen levels. Patients with non-cirrhotic alcoholic liver damage had decreased activator activity with elevated fibrinogen and α₁-antitrypsin levels. Primary biliary cirrhosis was associated with reduced activator activity and high levels of fibrinogen, α₁-antitrypsin and α₂-macroglobulin.

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Section: Discussionsupporting

confidence: 74%

mentioning

confidence: 99%

The Fibrinolytic Enzyme System in Acute and Chronic Liver Injury

Mowat¹,

Brunt²,

Ogston³

1974

Acta Haematol

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“…Determinations of fibrinopeptide A may enable one to distinguish between 'primary' and 'secondary' fibrinolysis due to DIC as it is relased from fibrinogen only by thrombin -that is, in the secondary form (Nossel et al, 1974). Fibrinolytic activity is, however, decreased in biliary obstruction and was associated with decreased levels of plasminogen activator activity in the serum, in an investigation by Jedrychowski et al, 1973). These authors speculated that inhibition of fibrinolysis might be due to altered lipid metabolism--and that the patient with biliary obstruction undergoing surgery might run the risk of increased thrombosis.…”

Section: Bleeding Tendencymentioning

confidence: 99%

Some clinical features of liver cell failure: an appraisal of their causes.

Read¹

1978

Gut

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“…17,18 To date, studies on the effect of severe cholestasis on the systemic inflammatory state are limited in scope and did not include an incisive analysis of coagulation and fibrinolysis. 6,8,19,20 Therefore, this study was conducted to assess the activation state of coagulation and fibrinolysis in cholestatic patients before and after PBD.…”

mentioning

confidence: 99%