Fibrinolysis of mechanical prosthetic valve thrombosis

Abstract

These results indicate that FT is effective in most cases of PHVT, regardless of prosthesis or site involved. However, embolism, hemorrhage, and death were not uncommon after lytic therapy of left-sided PHVT, limiting its application to patients at high risk with alternative treatment.

Prevention and Treatment of Thrombosis in Pediatric and Congenital Heart Disease

“…In adults, success is ≈75% with a 25% rate of complications such as bleeding, systemic thromboembolism, failure resulting in reoperation, and death. 335,336,[341][342][343][344][345][346] There is experience with thrombolytic therapy in children for thrombotic occlusion of prosthetic valves, and the results seem similar to the adult experience. 51a,345,347-351 The management of pediatric patients with valve thrombosis should mirror that outlined for adults in the ACC/AHA guidelines for management of patients with valvular heart disease and the eighth edition of the American College of Chest Physicians evidence-based clinical practice guidelines.…”

Successful application of thrombolysis and angioplasty in case of mechanical aortic valve and coronary graft thrombosis

“…Despite the lack of randomized controlled prospective trials comparing surgery and thrombolytic therapy in the case of PVT, fibrinolysis has been recommended to critically sick patients with functional class III or IV, and high surgical operative risk as the class IIb recommendation (level of evidence: B) by ACC/AHA (1). The experience using thrombolysis has been summarized in recent European recommendations (2), review papers (3) and single center reports (4).…”

Trombose aguda de prótese mecânica mitral tratada efetivamente com trombólise

“…The argument in favor of surgery in NYHA functional class I or II patients is based on the low mortality in this group, as opposed to the high risk of embolism (12-17%) resulting from thrombolysis 7 . In a review of 200 articles on thrombolysis in PVT of left chambers, Lengyel et al found an initial success rate of 82%, with a thromboembolism rate of 12% and mortality rate of 10% 8 .…”