Fibrinolytic activity of the gastric mucosa in Ménétrièr's disease

Abstract

Biopsies of the gastric mucosa were collected from two patients with Ménétrièr's disease before, during, and after treatment with cimetidine and studied for fibrinolytic activity. The fibrinolytic activity in the homogenates or in the potassium thiocyanate soluble fractions increased markedly during the treatment. Immunological characterization of the activity indicated that its major component was an endothelium-derived type of plasminogen activator, and that the increase in activity was caused solely by an increase in the concentration of this component. This suggests an increase in the vascularity of the mucosal layers during treatment thus reflecting a repair process.

Guidelines for diagnosis and treatment of chronic gastritis inChina(2022,Shanghai)

“…There is a lack of effective treatment for Ménétrier's disease. Most previous studies are case reports that report the use of antibiotics, 128 glucocorticoids, 129 and acid‐suppressants, 130 etc. A previous study has indicated that long‐acting somatostatin may be effective for the treatment of Ménétrier's disease, 131 and that hypoalbuminemia and anemia should be corrected concurrently.…”