Fibrinolytic response in subjects with hypertriglyceridemia and low HDL cholesterol

Cimminiello, Claudio; P, Vigorelli; Piliego, T.; Soncini, Marco; Toschi, Vincenzo; Arpaia, Guido; Perolini, S.; Bonfardeci, C

doi:10.1016/s0753-3322(97)85585-0

Cited by 6 publications

(5 citation statements)

References 20 publications

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“…26 Furthermore, in a study of young adults, central obesity was correlated with high blood pressure and levels of insulin and PAI-1 while being negatively correlated with HDL-C. 27 Hypertriglyceridemia is suggested to stimulate abdominal adipocytes to excrete PAI-1 into blood. 28,29 PAI-1 levels are elevated in established hypertension. 30 Two studies reported differences between PAI-1 levels in WCH and NT groups.…”

Section: Discussionmentioning

confidence: 98%

Hypertension and hemostatic/fibrinolytic balance disorders

Tabak¹,

Gelışgen²,

Uzun³

et al. 2009

CIM

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Background: Hypertension is one of the principal risk factors for cardiovascular disease. We aimed to evaluate the impact of hypertension on fibrinolytic balance and endothelial function by measuring plasma levels of plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator antigen (tPA), tPA/PAI-1 complex and fibrinogen. Methods: Patients enrolled into the study were divided into four groups: 22 essential hypertensive (EH), 22 white coat hypertensive (WCH), 22 renovascular hypertensive (RH) and 22 normotensive control subjects. Plasma PAI-1, tPA, tPA/PAI-1 complex levels were measured by enzyme linked immunosorbent assays. Results: There was no difference in the systolic and diastolic blood pressure measurements of the EH and RH groups. The four groups were comparable for age, gender, smoking habits and BMI. Patients with EH, RH and WCH had increased plasma levels of PAI-1, tPA, tPA/PAI-1 complex and fibrinogen compared with controls. No fibrinolytic parameter was associated with blood pressure in hypretensive subjects. Conclusion: This prospective study showed that fibrinolytic markers such as PAI-1, tPA, tPA/PAI-1 complex are independently associated with the development of hypertension. This supports the hypothesis that disturbances in fibrinolysis precede a cardiovascular event. Therefore, hypertension may be associated with impaired fibrinolysis.

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Section: Discussionmentioning

confidence: 98%

Hypertension and hemostatic/fibrinolytic balance disorders

Tabak¹,

Gelışgen²,

Uzun³

et al. 2009

CIM

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“…The manifestation of both central obesity and the metabolic syndrome components among these young adults was similar to the presentation in the older adult populations, except that older adult populations with the metabolic syndrome tend to have higher percentages of central obesity and hypertriglyceridemia. Hypertriglyceridemia is believed to stimulate abdominal adipocytes to excrete free PAI-1 into the circulation (Cimminiello et al, 1997;Ford et al, 2002); therefore, the adult populations with metabolic syndrome tend to have higher free PAI-1 concentrations.…”

Section: Discussionmentioning

confidence: 99%

Central Obesity, the Metabolic Syndrome, and Plasminogen Activator Inhibitor‐1 in Young Adults

Appel¹,

Harrell²,

Davenport³

2005

Journal of the American Academy of Nurse Practitioners

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Purpose To determine the association of central obesity with the components of the metabolic syndrome (i.e., hyperinsulinemia, hypertension, hypertriglyceridemia, low levels of high‐density lipoprotein cholesterol [HDL‐C]) and plasma levels of plasminogen activator inhibitor‐1 (PAI‐1) in young adults. We hypothesized that central obesity as determined by waist circumference would be predictive of components of the metabolic syndrome and of PAI‐1. Data sources Participants in this descriptive study consisted of 85 healthy young adults aged 19–22 years, 62% women who fasted for 12 h prior to data collection in the General Clinical Research Center at a major university hospital medical center in the southeastern United States. Conclusions The majority of the participants had one or more components of the metabolic syndrome (n= 43, 51%). Central obesity was present in 14.1% and was more common in women than men (χ2= 5.11; p= 0.021). Central obesity was significantly and positively correlated with elevated blood pressure (BP) and levels of insulin and PAI‐1 while being negatively correlated with HDL‐C. In multiple regression analyses, diastolic BP, insulin, and HDL‐C were predictors of waist circumference (R2= 0.615). In a separate multiple regression, PAI‐1 was predicted by waist circumference (R2= 0.331). Implications for practice Many otherwise healthy young adults have one or more components of the metabolic syndrome. Assessment and institution of preventative measures for obesity and the components of the metabolic syndrome should begin in childhood. Furthermore, determination of waist circumference especially in young women may aid the practitioner to identify those at risk for the metabolic syndrome earlier in their disease trajectory. Furthermore, insulin resistance is believed to occur initially in the trajectory of the metabolic syndrome, making it a principal contender for suitable interventions to reduce risk for both type 2 diabetes and cardiovascular disease (CVD). Homeostatic model assessment for insulin resistance was used to assess for insulin resistance among the euglycemic participants. Recording the presence of insulin resistance will aid the practitioner in determining if a low‐risk patient is in peril for development of type 2 diabetes and/or CVD. Early cardiovascular risk recognition is vital to clinical practice as it allows more time for the practitioner to counsel patients for the essential planning needed to make lifestyle changes.

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“…TG increase in many infectious and inflammatory diseases and have often been considered as acute-phase proteins [18]. Moreover, such conditions are often associated with an imbalance of components of the fibrinolytic system (plasminogen activator inhibitor-1 and tissue-type plasminogen activator) and reduced fibrinolytic activity [21,22]. Moreover, such conditions are often associated with an imbalance of components of the fibrinolytic system (plasminogen activator inhibitor-1 and tissue-type plasminogen activator) and reduced fibrinolytic activity [21,22].…”

Section: Discussionmentioning

confidence: 99%

Untitled

Pasqui¹,

Puccetti

Bova

et al. 2002

Clin Exp Med

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Inflammatory and lipid factors share an important role in atherosclerosis. Recent studies showed the concomitant presence and increase of complement components and lipids both in the atherosclerotic plaque and the circulating blood. The aim of this study was to examine the relationship between the complement system and lipid disorders. We evaluated the circulating complement terminal complex C5b-9, a clear sign of complement activation, in three groups of 30 patients the first with hypercholesterolemia, the second with hypertriglyceridemia (associated with low values of HDL-cholesterol), the third with low levels of HDL-cholesterol compared with an equivalent group of matched normolipemic subjects. We found a significant increase of sC5b-9 in each group of patients compared with controls. The mean sC5b-9 level in the hypercholesterolemic population was 366.2 +/- 141.2 ng/ml (P<0.01), 395.4 +/- 118.2 ng/ml in the hypertrygliceridemic group (P<0.01), 414.8 +/- 126.4 ng/ml in the low HDL-chol subjects (P<0.01), and 182.0 +/- 40.8. ng/ml in the control group. Regression analysis showed a significant direct correlation between sC5b-9 and triglycerides (r=0.64), and a significant inverse correlation between sC5b-9, HDL-chol (r=-0.74), and apo-A1 (r=-0.68); no significant relationship was found between sC5b-9 and cholesterol. We suggest that complement activation is associated with the various lipid disorders and is more important in those dyslipidemic conditions in which other factors may be involved. In particular, hypertriglyceridemia may be associated with endothelial and fibrinolytic disturbances, and the decrease of HDL may induce the failure of the regulatory proteins transported by the same HDL.

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Fibrinolytic response in subjects with hypertriglyceridemia and low HDL cholesterol

Cited by 6 publications

References 20 publications

Hypertension and hemostatic/fibrinolytic balance disorders

Hypertension and hemostatic/fibrinolytic balance disorders

Central Obesity, the Metabolic Syndrome, and Plasminogen Activator Inhibitor‐1 in Young Adults

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