Fibrinolytic system of the armadillo Chaetophractus villosus (Xenarthra, Dasypodidae)

Comparative Fibrinolysis

“…Previous work from our laboratory, has identified the choice of the armadillo as an animal model because it adapts well to captivity conditions, endures repeated blood sampling, shows excellent tolerance to cardiac puncture and recovers quickly from anaesthesia (Bermúdez et al 2004;Casanave et al 2005;. Chaetophractus villosus has a hypercoagulable and hypofibrinolytic profile (Tentoni et al, 2008) as pigs, which are frequently used as an animal model in human research. Finally, the study of animals' haemostatic mechanisms is important in the field of zoology, for the advancement of scientific knowledge and in biomedicine, helping to select a suitable experimental animal model.…”

“…The α2PI concentration is similar to that measured in humans. DD was undetectable in the immunological test (Tentoni et al, 2008). Nevertheless we found FXIII activity in this mammal, with a range from 32 to 78 percent (%) in relation to the calibration curve obtained with a pool of healthy humans platelets poor plasma using Berichrom chromogenix assay (Dade Behring).…”

Fibrinolysis and Thrombolysis

“…Previous work from our laboratory, has identified the choice of the armadillo as an animal model because it adapts well to captivity conditions, endures repeated blood sampling, shows excellent tolerance to cardiac puncture and recovers quickly from anaesthesia (Bermúdez et al 2004;Casanave et al 2005;2006). Chaetophractus villosus has a hypercoagulable and hypofibrinolytic profile (Tentoni et al, 2008) as pigs, which are frequently used as an animal model in human research. Finally, the study of animals' haemostatic mechanisms is important in the field of zoology, for the advancement of scientific knowledge and in biomedicine, helping to select a suitable experimental animal model.…”