Among various benign fibro-osseous (BFO) lesions, cemento-osseous dysplasia (COD) is the most prevalent pathology. Placement of implants in the BFO tissue, especially in a jaw with COD, often presents clinical concerns. In this case report, we present an instance of complete removal of COD followed by bone grafting, and subsequent implant placement after confirming the restoration of normal bone structure. Radiographs confirmed that the implant and normal bone could be maintained without any problems during the long-term follow-up period. The area where COD was removed was filled with collagen material or xenogenic bone and replaced with normal bone. Therefore, if the COD lesion is removed from the area, replaced with normal bone, and an implant is placed, reasonable and stable outcomes can be anticipated.