Fibroadenomas: a multidisciplinary review of the variants

Akin, İşıl Başara; Balci, Pınar

doi:10.1016/j.clinimag.2020.10.058

Cited by 26 publications

(16 citation statements)

References 34 publications

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“…2c). Suppression of selection in the boundary-growth model is consistent with evidence of effectively neutral evolution in hepatocellular carcinoma 7 , as well as the existence of large, well-differentiated benign tumours such as leiomyomas 37 and fibroadenomas 38 that only rarely progress to malignancy.…”

Section: Resultssupporting

confidence: 62%

Spatial structure governs the mode of tumour evolution

et al. 2021

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Characterizing the mode—the way, manner or pattern—of evolution in tumours is important for clinical forecasting and optimizing cancer treatment. Sequencing studies have inferred various modes, including branching, punctuated and neutral evolution, but it is unclear why a particular pattern predominates in any given tumour. Here we propose that tumour architecture is key to explaining the variety of observed genetic patterns. We examine this hypothesis using spatially explicit population genetics models and demonstrate that, within biologically relevant parameter ranges, different spatial structures can generate four tumour evolutionary modes: rapid clonal expansion, progressive diversification, branching evolution and effectively almost neutral evolution. Quantitative indices for describing and classifying these evolutionary modes are presented. Using these indices, we show that our model predictions are consistent with empirical observations for cancer types with corresponding spatial structures. The manner of cell dispersal and the range of cell–cell interactions are found to be essential factors in accurately characterizing, forecasting and controlling tumour evolution.

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Section: Resultssupporting

confidence: 62%

Spatial structure governs the mode of tumour evolution

et al. 2021

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“…Myxoid broadenomas in patients with Carney complex are usually numerous (23). Myxoid broadenoma commonly presents as hypo-intense on T1WI and hyper-intense on T2WI with rapid homogenous enhancement and washout on DCE-MRI (24). US ndings of a myxoid broadenoma are similar with those of a simple broadenoma, as oval, parallel, circumscribed, homogeneous isoechoic or hypoechoic mass with thin internal echogenic septation.…”

Section: Discussionmentioning

confidence: 96%

Superficial angiomyxoma of the breast in a 25-year-old woman without carney’s complex: case report and literature review

Meng

Yin

Chen

et al. 2022

Preprint

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Background: Superficial angiomyxoma (SAM) is a rare, benign tumor characterized by scattered stellate or spindle cells and thin-walled blood vessels embedded in abundant myxoid stroma. It was first reported as a cutaneous myxoma associated with Carney complex in 1985, and lesions are commonly located in the eyelids, external ear canal, and nipples and often appear in multiples. In cases with no evidence of Carney complex, the incidence of breast SAM is extremely rare. Case presentation: We reported a case of a 25-year-old Chinese woman presented with a left breast lump in the subareolar region for three years and gradually increased in size. No evidence of Carney complex was noted. Breast ultrasonography (US) and magnetic resonance imaging (MRI) were undertaken with US BI-RADS 4A and MR BI-RADS 4, respectively. The patient denied biopsy and underwent a lumpectomy and was diagnosed with SAM. There was no tumor recurrence after 18 months of follow-up. Conclusion: This case report suggests that the preoperative US and MRI characteristics of breast SAM are specific and in accordance well with the histological appearances. Recognition of these imaging features may be helpful for the diagnosis of SAM. And complete excision and long-time regular follow-up after surgery are recommended.

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“…In MRI, they may have a variable appearance, as oval or round shaped masses, well-circumscribed or lobulated, either presenting a hypointense signal in T 1 weighted sequences, hyperintense signal in T 2 weighted sequences (usually due to hypercellularity) with enhancement, 5 they can also appear in a low signal intensity in T2 without any enhancement. When the lesion is enhanced, it may contain some internal septations, corresponding to collagenous bands.…”

Section: Discussionmentioning

confidence: 99%

Child gigantomastia revealing juvenile giant fibroadenomas

Belkouchi¹,

Haddad²,

Alaoui³

et al. 2022

BJR|case reports

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Breast masses in children and adolescents are uncommon. They can be caused by tumors such as fibroadenomas and phyllode tumors. These masses can cause gigantomastia, due to their rapidly increasing size. We report the case of a 12- year-old patient admitted in our department for a rapidly growing gigantomastia evolving in a matter of 8 months. Imaging features were in favor of juvenile giant fibroadenomas and diagnosis was confirmed by biopsy. Juvenile giant fibroadenomas are rare and represent 0.5–2% of all fibroadenomas, their exact etiology is unknown. They affect children and adolescents, with a predominance in African-American females. They may cause breast enlargement and asymmetry. The rapid growth causes anxiety and is the main cause of consultation. These tumors although benign, have to be treated rapidly because they can destruct up to 80% of the surrounding normal breast tissue, and conservatory treatment cannot be done.

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Fibroadenomas: a multidisciplinary review of the variants

Cited by 26 publications

References 34 publications

Spatial structure governs the mode of tumour evolution

Spatial structure governs the mode of tumour evolution

Superficial angiomyxoma of the breast in a 25-year-old woman without carney’s complex: case report and literature review

Child gigantomastia revealing juvenile giant fibroadenomas

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