Fibroblast-derived CXCL14 aggravates crystalline silica–induced pulmonary fibrosis by mediating polarization and recruitment of interstitial macrophages

You, Yichuan; Yuan, Haoyang; Min, Hui; Li, Chao; Chen, Jie

doi:10.1016/j.jhazmat.2023.132489

Cited by 12 publications

(7 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Speci cally, broblasts take on different roles as in ammatory cells themselves, recruiting leukocytes, enabling chronic in ammation in tissues (6). Our previous study indicated broblasts could mediate the polarization and recruitment of interstitial macrophages (7), highlighting the immunomodulatory role of broblasts in silicosis. As major proliferating stromal cells in silicosis, the critical immunomodulatory role of broblasts was underestimated.…”

Section: Introductionmentioning

confidence: 91%

“…CS particles were purchased from the U.S. Silica Company (Frederick, MD, USA). The characteristics of crystalline silica particles are described in detail (7,46). Brie y, the size distribution of CS particles was 97% < 5 µm in diameter and 80% < 3 µm in diameter, with a median diameter of 1.4 µm.…”

Section: Crystalline Silica Particlesmentioning

confidence: 99%

“…The mouse model of silicosis was established according to our previously published method (7,42,46). To establish silicosis model, mice were treated with 3.0 mg/50 µL CS suspension by intratracheal installation after anesthetization with pentobarbital sodium (30 mg/kg, Sigma-Aldrich) intraperitoneally.…”

Section: Murine Model Of Silicosis and Other Treatmentsmentioning

confidence: 99%

See 2 more Smart Citations

Mechanics-activated Fibroblasts orchestrating the plasticity of group 2 innate lymphoid cells propel the progression of silicosis

Li,

He,

Yuan

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Exposure to crystalline silica particle leads to silicosis characterized as progressive fibrosis. Fibroblasts are described as vital effector cells in fibrogenesis. Emerging studies identified immune sentinel role of fibroblasts in chronic disease, while their immune-modulatory role in silicosis remained elusive. Herein, we confirmed that a conversion of ILC2 to ILC1 closely involved in silicosis was mediated by activated fibroblast via IL-18. Mechanistically, Notch3 signaling in mechanics-activated fibroblasts modulated IL-18 production. The mice specific knockout Notch3 in fibroblast exerted retardatory progression of pulmonary fibrosis that tightly linked to attenuated conversion of ILCs. Our results indicated that the activated-fibroblast in silicotic lung served as a regulator of ILC2-ILC1 conversion that associated with silicosis progression via Notch3-IL-18 axis. The findings broadened the cognitive boundaries of the immune regulation of silicosis, also provide potential therapeutic targets in treating lung fibrotic diseases.

show abstract

Section: Introductionmentioning

confidence: 91%

Section: Crystalline Silica Particlesmentioning

confidence: 99%

See 1 more Smart Citation

Mechanics-activated Fibroblasts orchestrating the plasticity of group 2 innate lymphoid cells propel the progression of silicosis

Li,

He,

Yuan

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…In a crystalline silica-induced mouse PF, CXCL14 derived from fibroblast CXCL14 can mediate macrophages recruitment and M2 polarisation. 114 The regulation of PF by Tcells is intricate and multifaceted. Among them, Th cells are the predominant cell types regulating fibroblast functions.…”

Section: Pulmonary Fibrosismentioning

confidence: 99%

“…Moreover, fibroblasts can regulate macrophages in pulmonary fibrosis to form a regulatory circuit with each other to aggravate pulmonary fibrosis. In a crystalline silica‐induced mouse PF, CXCL14 derived from fibroblast CXCL14 can mediate macrophages recruitment and M2 polarisation 114 …”

Section: Fibroblast‐immunocyte Interactions and Organ Fibrosismentioning

confidence: 99%

Crosstalk between fibroblasts and immunocytes in fibrosis: From molecular mechanisms to clinical trials

Di,

Chen,

et al. 2024

Clinical & Translational Med

View full text Add to dashboard Cite

BackgroundThe impact of fibroblasts on the immune system provides insight into the function of fibroblasts. In various tissue microenvironments, multiple fibroblast subtypes interact with immunocytes by secreting growth factors, cytokines, and chemokines, leading to wound healing, fibrosis, and escape of cancer immune surveillance. However, the specific mechanisms involved in the fibroblast‐immunocyte interaction network have not yet been fully elucidated.Main body and conclusionTherefore, we systematically reviewed the molecular mechanisms of fibroblast‐immunocyte interactions in fibrosis, from the history of cellular evolution and cell subtype divisions to the regulatory networks between fibroblasts and immunocytes. We also discuss how these communications function in different tissue and organ statuses, as well as potential therapies targeting the reciprocal fibroblast‐immunocyte interplay in fibrosis. A comprehensive understanding of these functional cells under pathophysiological conditions and the mechanisms by which they communicate may lead to the development of effective and specific therapies targeting fibrosis.

show abstract

The multifaceted role of macrophage mitophagy in SiO₂‐induced pulmonary fibrosis: A brief review

Zhou,

Li,

et al. 2024

J of Applied Toxicology

View full text Add to dashboard Cite

Prolonged exposure to environments with high concentrations of crystalline silica (CS) can lead to silicosis. Macrophages play a crucial role in the pathogenesis of silicosis. In the process of silicosis, silica (SiO2) invades alveolar macrophages (AMs) and induces mitophagy which usually exists in three states: normal, excessive, and/or deficiency. Different mitophagy states lead to corresponding toxic responses, including successful macrophage repair, injury, necrosis, apoptosis, and even pulmonary fibrosis. This is a complex process accompanied by various cytokines. Unfortunately, the details have not been fully systematically summarized. Therefore, it is necessary to elucidate the role of macrophage mitophagy in SiO2‐induced pulmonary fibrosis by systematic analysis on the literature reports. In this review, we first summarized the current data on the macrophage mitophagy in the development of SiO2‐induced pulmonary fibrosis. Then, we introduce the molecular mechanism on how SiO2‐induced mitophagy causes pulmonary fibrosis. Finally, we focus on introducing new therapies based on newly developed mitophagy‐inducing strategies. We conclude that macrophage mitophagy plays a multifaceted role in the progression of SiO2‐induced pulmonary fibrosis, and reprogramming the macrophage mitophagy state accordingly may be a potential means of preventing and treating pulmonary fibrosis.

show abstract

Fibroblast-derived CXCL14 aggravates crystalline silica–induced pulmonary fibrosis by mediating polarization and recruitment of interstitial macrophages

Cited by 12 publications

References 55 publications

Mechanics-activated Fibroblasts orchestrating the plasticity of group 2 innate lymphoid cells propel the progression of silicosis

Mechanics-activated Fibroblasts orchestrating the plasticity of group 2 innate lymphoid cells propel the progression of silicosis

Crosstalk between fibroblasts and immunocytes in fibrosis: From molecular mechanisms to clinical trials

The multifaceted role of macrophage mitophagy in SiO₂‐induced pulmonary fibrosis: A brief review

Contact Info

Product

Resources

About

Fibroblast-derived CXCL14 aggravates crystalline silica–induced pulmonary fibrosis by mediating polarization and recruitment of interstitial macrophages

Cited by 12 publications

References 55 publications

Mechanics-activated Fibroblasts orchestrating the plasticity of group 2 innate lymphoid cells propel the progression of silicosis

Mechanics-activated Fibroblasts orchestrating the plasticity of group 2 innate lymphoid cells propel the progression of silicosis

Crosstalk between fibroblasts and immunocytes in fibrosis: From molecular mechanisms to clinical trials

The multifaceted role of macrophage mitophagy in SiO2‐induced pulmonary fibrosis: A brief review

Contact Info

Product

Resources

About

The multifaceted role of macrophage mitophagy in SiO₂‐induced pulmonary fibrosis: A brief review