Fibroblast growth factor 2

Nickle, Audrey; Ko, Sebastian; Merrill, Amy E.

doi:10.1016/j.diff.2023.10.001

Differentiation

2024

DOI: 10.1016/j.diff.2023.10.001

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Fibroblast growth factor 2

Audrey Nickle,

Sebastian Ko,

Amy E. Merrill

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2024

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Cited by 2 publications

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MicroRNA binding site variants–new potential markers of primary osteoporosis in men and women

Yalaev,

Deev,

Tyurin

et al. 2024

Front. Genet.

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IntroductionThe identification of significant DNA markers of primary osteoporosis may gain new insights by studying genome regions involved in mechanisms of epigenetic regulation through interactions with microRNAs.MethodsThe authors searched for associations of polymorphic variants of microRNA binding sites of mRNA target genes and polymorphic loci of microRNA genes with primary osteoporosis in a cohort of women and men from the Volga-Ural region of Russia (N = 1.177).ResultsUsing case-control association analysis, the authors found that rs1061947 (COL1A1), rs10793442 (ZNF239), rs6854081 (FGF2), and rs11614913 (miR-196a) were associated with osteoporotic fractures; rs5854 (MMP1) and rs2910164 (miR-146a) were associated with low bone mineral density; and rs10098470 (TPD52), rs11540149 (VDR), rs1042673 (SOX9), rs1054204 (SPARC), and rs1712 (FBXO5) were markers of both fractures and low bone mineral density. Among the identified associations, ethno specific trends were found, as well as sex-specific associations. Prognostic models were developed, among which the model for predicting osteoporosis in general in women (Area Under Curve = 0.909) achieved the highest level of predictive value. Thus, the potential role of polymorphic variants of microRNA binding sites in the development of primary osteoporosis in men and women from the Volga-Ural region of Russia was demonstrated.

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MicroRNA binding site variants–new potential markers of primary osteoporosis in men and women

Yalaev,

Deev,

Tyurin

et al. 2024

Front. Genet.

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Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases

Issa,

Fayoud,

Shaimardanova

et al. 2024

Biomedicines

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Hereditary neurodegenerative diseases (hNDDs) such as Alzheimer’s, Parkinson’s, Huntington’s disease, and others are primarily characterized by their progressive nature, severely compromising both the cognitive and motor abilities of patients. The underlying genetic component in hNDDs contributes to disease risk, creating a complex genetic landscape. Considering the fact that growth factors play crucial roles in regulating cellular processes, such as proliferation, differentiation, and survival, they could have therapeutic potential for hNDDs, provided appropriate dosing and safe delivery approaches are ensured. This article presents a detailed overview of growth factors, and explores their therapeutic potential in treating hNDDs, emphasizing their roles in neuronal survival, growth, and synaptic plasticity. However, challenges such as proper dosing, delivery methods, and patient variability can hinder their clinical application.

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Fibroblast growth factor 2

Cited by 2 publications

References 150 publications

MicroRNA binding site variants–new potential markers of primary osteoporosis in men and women

MicroRNA binding site variants–new potential markers of primary osteoporosis in men and women

Growth Factors and Their Application in the Therapy of Hereditary Neurodegenerative Diseases

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