2022
DOI: 10.3390/vision6040058
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Fibroblast Growth Factor-2 (FGF-2) Expression in Pterygia Using Cell Spot Arrays

Abstract: Fibroblast growth factor (FGF) is a main regulator of cell differentiation, cell migration and angiogenesis in normal and abnormal conjunctiva epithelia, but specific mechanisms of its aberrant expression are yet to be investigated. In the present study, we investigated FGF-2 protein expression within several pterygia. Using a liquid-based cytology assay, we obtained cell specimens from pterygia and healthy tissues directly from patients. A combination of immunocytochemistry followed by digital image analysis … Show more

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Cited by 2 publications
(2 citation statements)
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“…The balance of pro-and anti-angiogenic factors determines the ability of these cancer cells. Vascular Endothelial Growth Factor (VEGF) [64], Platelet-derived Growth Factor (PDGF) [65], acidic and basic fibroblast growth factors (FGF 1 and 2) [66], and IL-8 are pro-angiogenic factors [67]. Interferons, proteolytic fragments such as angiostatin and endostatin, and thrombospondin-1 are all negative regulators of angiogenesis [1,64,65,66,68].…”
Section: Oscc Capable Of Inducing Angiogenesismentioning
confidence: 99%
“…The balance of pro-and anti-angiogenic factors determines the ability of these cancer cells. Vascular Endothelial Growth Factor (VEGF) [64], Platelet-derived Growth Factor (PDGF) [65], acidic and basic fibroblast growth factors (FGF 1 and 2) [66], and IL-8 are pro-angiogenic factors [67]. Interferons, proteolytic fragments such as angiostatin and endostatin, and thrombospondin-1 are all negative regulators of angiogenesis [1,64,65,66,68].…”
Section: Oscc Capable Of Inducing Angiogenesismentioning
confidence: 99%
“…The balance of pro-and anti-angiogenic factors determines the ability of these cancer cells. Vascular Endothelial Growth Factor (VEGF) [64], Platelet-derived Growth Factor (PDGF) [65], acidic and basic fibroblast growth factors (FGF 1 and 2) [66], and IL-8 are pro-angiogenic factors [67]. Interferons, proteolytic fragments such as angiostatin and endostatin, and thrombospondin-1 are all negative regulators of angiogenesis [1,64,65,66,68].…”
Section: Oscc Capable Of Inducing Angiogenesismentioning
confidence: 99%