Fibroblast Growth Factor 22 Is Not Essential for Skin Development and Repair but Plays a Role in Tumorigenesis

Jarosz, Monika; Robbez-Masson, Luisa; Chioni, Athina‐Myrto; Cross, Barbara A.; Rosewell, Ian; Grose, Richard

doi:10.1371/journal.pone.0039436

Cited by 23 publications

(13 citation statements)

References 33 publications

(62 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FGF22 is preferentially expressed in the inner root sheath of the hair follicle40, but its role in hair development or maintenance is not yet clearly understood41. The independent, damaging mutations in baleen and toothed whales suggest that FGF22 was no longer necessary when the common ancestor of the cetaceans lost its body hair (Fig.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans

Nam

Lee

Chung

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Cetacean body structure and physiology exhibit dramatic adaptations to their aquatic environment. Fibroblast growth factors (FGFs) are a family of essential factors that regulate animal development and physiology; however, their role in cetacean evolution is not clearly understood. Here, we sequenced the fin whale genome and analysed FGFs from 8 cetaceans. FGF22, a hair follicle-enriched gene, exhibited pseudogenization, indicating that the function of this gene is no longer necessary in cetaceans that have lost most of their body hair. An evolutionary analysis revealed signatures of positive selection for FGF3 and FGF11, genes related to ear and tooth development and hypoxia, respectively. We found a D203G substitution in cetacean FGF9, which was predicted to affect FGF9 homodimerization, suggesting that this gene plays a role in the acquisition of rigid flippers for efficient manoeuvring. Cetaceans utilize low bone density as a buoyancy control mechanism, but the underlying genes are not known. We found that the expression of FGF23, a gene associated with reduced bone density, is greatly increased in the cetacean liver under hypoxic conditions, thus implicating FGF23 in low bone density in cetaceans. Altogether, our results provide novel insights into the roles of FGFs in cetacean adaptation to the aquatic environment.

show abstract

Section: Discussionmentioning

confidence: 99%

Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans

Nam

Lee

Chung

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Since TGF- β 1 signaling has been implicated in collagen deposition, TGF- β 1 is also important in multiple aspects of wound healing, including epithelial growth, vascular endothelial growth, and collagen deposition [ 25 ]. FGF7 is known to regulate genes that encode cytoprotective mediators [ 26 ] and the transcription factor Nrf2, in addition to the antioxidant enzyme gene targets of Nrf2 [ 27 ]. Interestingly, a recombinant form of FGF7 is used clinically in the treatment of oral mucositis [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…Because of inflammation, serum levels of ROM also increase in periodontitis patients [ 36 ]. Additionally, administration of hydrogen-rich water decreases periodontitis-induced systemic ROM, which in turn inhibits inflammation [ 26 ]. It is known that NO and nitrotyrosine levels significantly increase in wounds and wounded tissue [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Hydrogen‐Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model

Tamaki

Orihuela-Campos

Fukui

et al. 2015

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

The wound healing process attempts to restore the integrity and function of the injured tissue. Additionally, proinflammatory cytokines, growth factors, and oxidative stress play important roles in wound healing. The aim of this study was to determine whether hydrogen-rich water intake induces the activation of the Nrf2/antioxidant defense pathway in rat palatal tissue, thereby reducing systemic oxidative stress and proinflammatory cytokine levels and promoting healing-associated genes. A circular excisional wound was created in the oral palatal region, and the wound healing process was observed. The rats were divided into two experimental groups in which either hydrogen-rich water or distilled water was consumed. In the drinking hydrogen-rich water, the palatal wound healing process was accelerated compared to that in the control group. As molecular hydrogen upregulated the Nrf2 pathway, systemic oxidative stresses were decreased by the activation of antioxidant activity. Furthermore, hydrogen-rich water intake reduced proinflammatory cytokine levels and promoted the expression of healing-associated factors in rat palatal tissue. In conclusion, hydrogen-rich water intake exhibited multiple beneficial effects through activation of the Nrf2/antioxidant defense pathway. The results of this study support the hypothesis that oral administration of hydrogen-rich water benefits the wound healing process by decreasing oxidative stress and inflammatory responses.

show abstract

“…In contrast to the oncogenic properties of many FGF ligands, in some human colon and endometrial cancers that lack β‐catenin activation, homozygosity for loss‐of‐function somatic mutations in FGF9 have been observed. Additionally, mice lacking Fgf22 have normal skin, but show increased papilloma formation in a DMBA/TPA induced tumorigenesis model (Table (a)). These examples show that in at least some cases, FGF signaling can also function to suppress tumorigenesis, possibly by promoting cell differentiation .…”

Section: Fgfr3mentioning

confidence: 99%

The Fibroblast Growth Factor signaling pathway

Ornitz

Itoh

2015

WIREs Developmental Biology

1,679

1,791

View full text Add to dashboard Cite

The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF receptors (FGFRs). Interaction of FGF ligands with their signaling receptors is regulated by protein or proteoglycan cofactors and by extracellular binding proteins. Activated FGFRs phosphorylate specific tyrosine residues that mediate interaction with cytosolic adaptor proteins and the RAS-MAPK, PI3K-AKT, PLCγ, and STAT intracellular signaling pathways. Four structurally related intracellular non-signaling FGFs interact with and regulate the family of voltage gated sodium channels. Members of the FGF family function in the earliest stages of embryonic development and during organogenesis to maintain progenitor cells and mediate their growth, differentiation, survival, and patterning. FGFs also have roles in adult tissues where they mediate metabolic functions, tissue repair, and regeneration, often by reactivating developmental signaling pathways. Consistent with the presence of FGFs in almost all tissues and organs, aberrant activity of the pathway is associated with developmental defects that disrupt organogenesis, impair the response to injury, and result in metabolic disorders, and cancer. © 2015 Wiley Periodicals, Inc.

show abstract

Fibroblast Growth Factor 22 Is Not Essential for Skin Development and Repair but Plays a Role in Tumorigenesis

Cited by 23 publications

References 33 publications

Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans

Analysis of the FGF gene family provides insights into aquatic adaptation in cetaceans

Hydrogen‐Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model

The Fibroblast Growth Factor signaling pathway

Contact Info

Product

Resources

About