Fibroblast Growth Factor 5 Inhibits Hair Growth by Blocking Dermal Papilla Cell Activation

Ota, Yutaka; Saitoh, Yuhei; Suzuki, Satoshi; Ozawa, Kazuo; Kawano, Mitsuko; Imamura, Toru

doi:10.1006/bbrc.2001.6140

Cited by 65 publications

(53 citation statements)

References 44 publications

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“…Finally, it has been shown that what we call the LPC is a source of FGF5 that controls features of the anagen including its duration (Hebert et al, 1994;Ota et al, 2002). More generally, it is possible that the LPC plays a wider role as a signalling centre, potentially interacting with the dermal papilla and the PPZ.…”

Section: The Basal Ors and Its Growthmentioning

confidence: 98%

Redefining the structure of the hair follicle by 3D clonal analysis

Sequeira

Nicolas

2012

Development

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SUMMARYThe hair follicle (HF) is a multi-tissue mini-organ that self-renews periodically. However, the cellular organisation of this much-studied model is not fully understood. The structures of the outer layer and of the bulb, which ensures HF growth, have not been completely established. To clarify these points, we have conducted in vivo clonal analyses with 3D imaging in mice. The upper two-thirds of the HF outer layer consists of two clonally unrelated groups of cells that exhibit different modes of growth. They correspond to the basal outer root sheath (ORS) and the companion layer (Cp). The basal ORS has an unusual anisotropic mode of growth from a suprabulbar zone, which we named the privileged proliferation zone. The Cp has a stem/transient-amplifying mode of growth and is shown to be an HF internal structure. Furthermore, we describe an additional element, the bulb outer layer, which is contiguous and shares markers (e.g. Lgr5) with the basal ORS but is formed by a separate lineage that belongs neither to the ORS nor Cp lineage. It represents a novel element with proximal cells that are contiguous with the germinative layer in the bulb. In reference to its shape and position we named it the lower proximal cup (LPC). These clonal hierarchies reveal a novel model of HF organisation and growth based on two major entities: the basal ORS and the LPC plus the seven internal layers.

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Section: The Basal Ors and Its Growthmentioning

confidence: 98%

Redefining the structure of the hair follicle by 3D clonal analysis

Sequeira

Nicolas

2012

Development

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“…The Th22 expression profile revealed several FGFs: FGF1 is a powerful mitogen exhibiting strong action on different cell types, including endothelial cells (32,33), and FGF5 also acts on neuronal differentiation (34) and is associated with inhibition of hair growth (35,36). These cytokines play a role in various stages of development and morphogenesis as well as in angiogenesis and wound healing processes.…”

Section: Figurementioning

confidence: 99%

Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling

et al. 2009

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Th subsets are defined according to their production of lineage-indicating cytokines and functions. In this study, we have identified a subset of human Th cells that infiltrates the epidermis in individuals with inflammatory skin disorders and is characterized by the secretion of IL-22 and TNF-α, but not IFN-γ, IL-4, or IL-17. In analogy to the Th17 subset, cells with this cytokine profile have been named the Th22 subset. Th22 clones derived from patients with psoriasis were stable in culture and exhibited a transcriptome profile clearly separate from those of Th1, Th2, and Th17 cells; it included genes encoding proteins involved in tissue remodeling, such as FGFs, and chemokines involved in angiogenesis and fibrosis. Primary human keratinocytes exposed to Th22 supernatants expressed a transcriptome response profile that included genes involved in innate immune pathways and the induction and modulation of adaptive immunity. These proinflammatory Th22 responses were synergistically dependent on IL-22 and TNF-α. Furthermore, Th22 supernatants enhanced wound healing in an in vitro injury model, which was exclusively dependent on IL-22. In conclusion, the human Th22 subset may represent a separate T cell subset with a distinct identity with respect to gene expression and function, present within the epidermal layer in inflammatory skin diseases. Future strategies directed against the Th22 subset may be of value in chronic inflammatory skin disorders.

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“…Finally, the expression of dickkopf 1, a potent diffusible inhibitor of Wnt action, in the skin of transgenic mice produces a complete failure of placode formation prior to morphological or molecular signs of hair differentiation (Andl et al, 2002). In addition to Wnt, a number of other key signaling pathways, including those modulated by fibroblast growth factors (FGFs) (du Cros, 1993;Ota et al, 2002;Rosenquist and Martin, 1996;, bone morphogenetic proteins (BMPs) (Blessing et al, 1993;Botchkarev et al, 2001;Botchkarev et al, 2002;Kulessa et al, 2000), TGFβ (Foitzik et al, 2000;Foitzik et al, 1999;Paus et al, 1997) and Shh (Bitgood and McMahon, 1995;Chiang et al, 1999;StJacques et al, 1998), participate a reiterative manner during the hair follicle development (reviewed by Millar, 2002). More recently, different members of the TNFα receptor superfamily Kojima et al, 2000;Koppinen et al, 2001;Laurikkala et al, 2001;Laurikkala et al, 2002;Mikkola et al, 1999;Monreal et al, 1999;Naito et al, 2002;Schneider et al, 2001;Thesleff and Mikkola, 2002) and subsequent signaling through NFκB family of transcription factors (Schmidt-Ullrich et al, 2001) have also been involved in hair follicle morphogenesis and cycling.…”

Section: Introductionmentioning

confidence: 99%

Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130

et al. 2003

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The functions of p107 and p130, members of the retinoblastoma family, include the control of cell cycle progression and differentiation in several tissues. Our previous studies suggested a role for p107 and p130 in keratinocyte differentiation in vitro. We now extend these data using knockout animal models. We found impaired terminal differentiation in the interfollicular keratinocytes of p107/p130-double-null mice epidermis. In addition, we observed a decreased number of hair follicles and a clear developmental delay in hair, whiskers and tooth germs. Skin grafts of p107/p130-deficient epidermis onto NOD/scid mice showed altered differentiation and hyperproliferation of the interfollicular keratinocytes, thus demonstrating that the absence of p107 and p130 results in the deficient control of differentiation in keratinocytes in a cell-autonomous manner. Besides normal hair formation, follicular cysts, misoriented and dysplastic follicles, together with aberrant hair cycling, were also observed in the p107/p130 skin transplants. Finally, the hair abnormalities in p107/p130-null skin were associated with altered Bmp4-dependent signaling including decreased ∆Np63 expression. These results indicate an essential role for p107 and p130 in the epithelial-mesenchimal interactions.

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Fibroblast Growth Factor 5 Inhibits Hair Growth by Blocking Dermal Papilla Cell Activation

Cited by 65 publications

References 44 publications

Redefining the structure of the hair follicle by 3D clonal analysis

Redefining the structure of the hair follicle by 3D clonal analysis

Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling

Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130

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