Fibroblast growth factor and epidermal growth factor in hair development

Cros, D. L. du

doi:10.1016/0022-202x(93)90509-g

Cited by 46 publications

(27 citation statements)

References 75 publications

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“…EGFR is also localized in tissues that do not undergo rapid proliferation (Nanney et al, 1984), which suggests a complex regulatory role for this receptor. Previous reports demonstrate the effect of EGFR activation in hair physiology (Moore et al, 1983;Philip et al, 1985;Vassar and Fuchs, 1991;Cros, 1993). These data, together with EGFR localization in the outer root sheath of hair follicles (Nanney et al, 1984), point to EGFR as a major regulator of hair biology (reviewed in Hardy, 1992).…”

Section: Introductionmentioning

confidence: 81%

Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure.

et al. 1995

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Epidermal growth factor receptor (EGFR) is a key regulator of keratinocyte biology. However, the physiological role of EGFR in vivo has not been well established. To analyze the role of EGFR in skin, we have generated transgenic mice expressing an EGFR dominant negative mutant in the basal layer of epidermis and outer root sheath of hair follicles. Mice expressing the mutant receptor display short and waved pelage hair and curly whiskers during the first weeks of age, but subsequently pelage and vibrissa hairs become progressively sparser and atrophic. Eventually, most mice present severe alopecia. Histological examination of the skin of transgenic mice shows striking alterations in the development of hair follicles, which fail to enter into catagen stage. These alterations eventually lead to necrosis and disappearance of the follicles, accompanied by strong infiltration of the skin with inflammatory elements. The interfollicular epidermis of these mice shows marked hyperplasia, expression of hyperproliferation‐associated keratin K6 and increased 5‐bromo‐2‐deoxyuridine incorporation. EGFR function was inhibited in transgenic skin keratinocytes, since in vivo and in vitro autophosphorylation of EGFR was almost completely abolished on EGF stimulation. These results implicate EGFR in the control of hair cycle progression, and provide new information about its role in epidermal growth and differentiation.

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Section: Introductionmentioning

confidence: 81%

Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure.

et al. 1995

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“…Nine pathways are active only in embryonic skin. These include such important pathways for skin morphogenesis as FGF 34,40,[46][47][48][49] and WNT 20,[33][34][35][36][37] . Four pathways are specifically active in wounded skin, and included known regulators of wound-induced skin repair SPP1 (osteopontin) interactions are defined by the interactions with multi-subunits that are partially identified by these tools.…”

Section: Joint Learning Of Conserved and Context-specific Communicatimentioning

confidence: 99%

Inference and analysis of cell-cell communication using CellChat

Jin¹,

Guerrero‐Juarez²,

Zhang³

et al. 2020

Preprint

254

417

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Understanding global communications among cells requires accurate representation of cell-cell signaling links and effective systems-level analyses of those links. We constructed a database of interactions among ligands, receptors and their cofactors that accurately represents known heteromeric molecular complexes. Based on mass action models, we then developed CellChat, a tool that is able to quantitively infer and analyze intercellular communication networks from single-cell RNA-sequencing (scRNA-seq) data. CellChat predicts major signaling inputs and outputs for cells and how those cells and signals coordinate for functions using network analysis and pattern recognition approaches. Through manifold learning and quantitative contrasts, CellChat classifies signaling pathways and delineates conserved and context-specific pathways across different datasets. Applications of CellChat to several mouse skin scRNA-seq datasets for embryonic development and adult wound healing shows its ability to extract complex signaling patterns, both previously known as well as novel. Our versatile and easy-to-use toolkit CellChat and a web-based Explorer (http://www.cellchat.org/) will help discover novel intercellular communications and build a cell-cell communication atlas in diverse tissues.

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“…The main reservoir of growth factors in the body are alphagranules of platelets (23) and growth factors involved on hair follicle cycling are mainly vascular endothelial growth factor (VEGF) (24) epidermal growth factor (EGF) (25), fibroblast growth factor (26,27) and insulin-like growth factor (IGF) (28). Adenosine diphosphate (ADP), serotonin and calcium are also released from dense granules and are important in the recruitment of new platelets and coagulation cascade (29).…”

Section: Introductionmentioning

confidence: 99%

Randomized controlled trial on a PRP-like cosmetic, biomimetic peptides based, for the treatment of alopecia areata

Rinaldi

Mora

Pinto

et al. 2019

Journal of Dermatological Treatment

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Background: Alopecia areata (AA) is a non-scarring auto-immune hair disorder. Recent researches explained the role of growth factors (GFs) in hair follicle cycling. The main reservoir of GFs are alpha-granules of platelets and novel procedures have been implemented aimed at collecting platelet-rich plasma (PRP). PRP has been safely implemented in many medical applications and has also been successfully used as alternative cell-based therapy for the treatment of hair growth disorders, among which also AA. Objectives: By means of a randomized double-blinded, placebo and active-controlled, parallel group study we have studied the efficacy of a cosmetic product (named TR-M-PRP plus) comprising biomimetic peptides specific for hair growth, mimicking PRP composition for the treatment of AA. Subjects were treated for three months and evaluated, at the end of the study and after one month of follow-up, as regards hair growth using SALT score. Results: TR-M-PRP plus-like topic produced a statistically significant (p < .001) clinical improvement in SALT score after 3 months of therapy, compared to baseline. Hair growth results further improved after 1 month of follow-up. Conclusions: This clinical investigation suggests that the biotechnological designed PRP-like cosmetic could represent a valid and safer alternative to autologous PRP for the treatment of AA.

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Fibroblast growth factor and epidermal growth factor in hair development

Cited by 46 publications

References 75 publications

Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure.

Expression of a dominant negative mutant of epidermal growth factor receptor in the epidermis of transgenic mice elicits striking alterations in hair follicle development and skin structure.

Inference and analysis of cell-cell communication using CellChat

Randomized controlled trial on a PRP-like cosmetic, biomimetic peptides based, for the treatment of alopecia areata

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