Fibroblast growth factor stimulates bone formation Bone induction studied in rats

Basic fibroblast growth factor and bone induction in rats

“…The way of applying the bFGF is important: dropping a bFGF-saline solution (140 ng) onto the dry implant was not effective (Aspenberg and Lohmander 1989). Risto et al (1991) found that continuous application of a PDGF solution with a tube into similar implants seemed to cause resorption, and this was our experience with bFGF also.…”

“…The mean gel volume per implant was 32.9 k 7.3 pL. In previous studies there was no difference between implants which were treated with the gel alone or moistened with saline (Aspenberg and Lohmander 1989). In this study, controls were only treated with saline.…”

Local application of recombinant human fibroblast growth factor‐2 on bone repair: A dose–escalation prospective trial on patients with osteotomy

“…Based on the evidence of extensive studies using various animal models, [6][7][8][9][10][11][12][13][14][15] this study for the first time showed clinical evidence that rhFGF-2 in gelatin hydrogel accelerated radiographic bone union of the closing wedge high tibial osteotomy. Because most osteotomies can heal only with appropriate fixations, and in fact, all patients even of the low dosage group eventually achieved radiographic bone union in the present study, the rhFGF-2 application may not have yielded bone union by preventing nonunion, but just accelerated bone union.…”

“…We and others have reported the anabolic effect of local and systemic administrations of FGF-2 on bone formation using several animal models including nonhuman primates. [6][7][8][9][10][11][12][13][14][15] A single local application of FGF-2 facilitated the healing of bone fracture and segmental bone defect in normal and diabetic rats, rabbits, dogs, and monkeys; [6][7][8][9][10][11][12] stimulated bone formation in callotasis bone lengthening in rabbits; 13 and increased bone mass intraosseously in normal and ovariectomized rats and rabbits. 14 In addition, a daily systemic administration of FGF-2 facilitated endosteal bone formation.…”

Fibroblast Growth Factor (FGF)-2 Directly Stimulates Mature Osteoclast Function through Activation of FGF Receptor 1 and p42/p44 MAP Kinase

“…In bone tissues, FGF-2 is produced by cells of osteoblastic lineage, is accumulated in bone matrix, and acts as an autocrine/paracrine factor for bone cells (6 -10). We and others have reported that the exogenous application of FGF-2 has stimulatory effects on bone formation in several in vivo models as a pharmacological action of FGF-2 (11)(12)(13)(14)(15)(16)(17). On the other hand, in vitro studies revealed that high concentrations of FGF-2 (10 Ϫ9 -10 Ϫ8 M) stimulated osteoclastogenesis in bone marrow culture (18) and bone resorption in bone organ cultures (19,20).…”