Fibroblastic and myofibroblastic tumors of the head and neck: Comprehensive imaging-based review with pathologic correlation

Hourani, Roula; Taslakian, Bedros; Shabb, Nina S.; Nassar, Lara; Hourani, Mukbil; Moukarbel, Roger V; Sabri, Alain; Rizk, T.

doi:10.1016/j.ejrad.2014.10.017

Cited by 30 publications

(22 citation statements)

References 36 publications

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“…The histological diagnosis of juvenile angiofibroma does not usually pose a problem for the experienced head and neck pathologist, particularly when excised specimens are examined. Inflammatory sinonasal polyps, pyogenic granulomas, glomangiopericytomas, and solitary fibrous tumors should be considered in the differential diagnosis but, in our opinion, the diagnostic difficulties have been overemphasized, even in cases of hyalinized inflammatory sinonasal polyps . Distinction from the rare sinonasal vascular leiomyoma may be more challenging, although clinical setting, sex, age, and site should be of help.…”

Section: Introductionmentioning

confidence: 94%

Nasal juvenile angiofibroma: Current perspectives with emphasis on management

et al. 2017

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Juvenile angiofibroma is an uncommon, benign, locally aggressive vascular tumor. It is found almost exclusively in young men. Common presenting symptoms include nasal obstruction and epistaxis. More advanced tumors may present with facial swelling and visual or neurological disturbances. The evaluation of patients with juvenile angiofibroma relies on diagnostic imaging. Preoperative biopsy is not recommended. The mainstay of treatment is resection combined with preoperative embolization. Endoscopic surgery is the approach of choice in early stages, whereas, in advanced stages, open or endoscopic approaches are feasible in expert hands. Postoperative radiotherapy (RT) or stereotactic radiosurgery seem valuable in long-term control of juvenile angiofibroma, particularly those that extend to anatomically critical areas unsuitable for complete resection. Chemotherapy and hormone therapy are ineffective. The purpose of the present review was to update current aspects of knowledge related to this rare and challenging disease. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1033-1045, 2017.

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Section: Introductionmentioning

confidence: 94%

Nasal juvenile angiofibroma: Current perspectives with emphasis on management

et al. 2017

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“…GCT-TS is generally located near joint spaces, while cystic lesion and metaplastic bone formation are absent, and calcification or ossification are very rare. The degree of contrast enhancement of GCT-TS is always higher [17,18] . NF is usually located in subcutaneous tissue and it shows hyperintensity on T 2 -weighted images caused by fluid-filled mucoid spaces.…”

Section: Some Authors Have Reported Considerable Overlap Between the mentioning

confidence: 93%

“…The MRI appearance of the NF is more variable. Emphasis is placed on the differential diagnosis of these giant cell-rich soft tissue neoplasms because clinical behavior, prognosis and treatment can significantly differ [15][16][17][18][19][20][21][22] .…”

Section: Some Authors Have Reported Considerable Overlap Between the mentioning

confidence: 99%

A Pilot Evaluation of Magnetic Resonance Imaging Characteristics Seen With Primary Soft Tissue Giant Cell Tumor in 2 patients

Zhang

Kang

Zhang

et al. 2019

Preprint

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Background Primary soft tissue giant cell tumor (GCT-ST) is a rare tumor with low malignant potential. Here we reported two cases of patients with soft tissue giant cell tumor in the limb, including their clinical and imaging findings (conventional Magnetic resonance imaging (MRI) and Diffusion weighted imaging (DWI)).Methods This retrospective study included two pathology-confirmed GCT-ST patients. Plain MRI, dynamic contrast enhancement MRI (DCE-MRI), and DWI were performed with a 3.0T whole-body MR scanner before surgery. The following characteristics of lesion were recorded: signal intensity on T 1 FSPGR and T 2 WI, morphology, maximum lesion size, time intensity curve (TIC) on DCE-MRI, and apparent diffusion coefficient (ADC) value from DWI.Results The maximum lesion size ranged from 4.0 cm to 6.0 cm. Signal intensities of all lesions were heterogeneous on T 1 FSPGR and T 2 WI. Nodular enhancements were observed for all lesions with either oval or irregular shapes on MRI. All lesion margins were blurred, and internal enhancements were heterogeneous on DCE-MRI. TIC appeared with a slow increase type. Lesions on DWI (b=500s/mm 2 ) were hyperintense with an higher mean ADC value of 2.19×10 −3 mm 2 /s compared to surrounding normal soft tissue (1.03×10 −3 mm 2 /s).Conclusions DWI may be a useful tool for differentiating benign soft tissue mass from giant cell-rich soft tissue neoplasms or malignant tumors.

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“…This arrangement usually contains a variable degree and arrangement of lymphocytes, plasma cells, histiocytes and eosinophils [5]. The spindle cells of IMTs are strongly immunoreactive for vimentin whereas the immunoreactivity for smooth muscle actin and desmin is variable [6]. The management of IMTs varies widely due to the rarity of the tumour and the lack of evidence and treatment protocols.…”

Section: Inflammatory Myofibroblastic Tumour (Imt)mentioning

confidence: 99%

“…The management of IMTs varies widely due to the rarity of the tumour and the lack of evidence and treatment protocols. Currently, the literature supports surgical excision as the mainstay of treatment with adjuvant radiotherapy for more aggressive IMTs [6]. Local recurrence is well known, but the risk of distant metastasis is small [3].…”

Section: Inflammatory Myofibroblastic Tumour (Imt)mentioning

confidence: 99%

Inflammatory Myofibroblastic Tumour of the Submandibular Gland

Triantafyllou¹,

Chudek²,

Thomas³

et al. 2019

SCR

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A 77-year-old man presented with a two-month history of a left sided, firm, and non-tender submandibular mass. The patient was systemically well with no history of weight loss or night sweats. On examination, there were no oropharyngeal abnormalities and flexible nasendoscopy was normal. An ultrasound scan and magnetic resonance imaging (MRI) confirmed a 2.8 x 2.4 x 4.3cm irregular mass in level I of the neck with a chain of small lymph nodes. Following inconclusive fine needle aspirations (FNA) and a core biopsy, an excision of the submandibular gland was performed. The pathology revealed an inflammatory myofibroblastic tumour (IMT) of the submandibular gland. To complete treatment a selective neck dissection and post-operative radiotherapy was performed. IMTs are rare, poorly understood tumours that can occur anywhere in the body. The incidence in the head and neck regions accounts for a small number of all cases. We present a rare case of IMT in the submandibular gland.

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Fibroblastic and myofibroblastic tumors of the head and neck: Comprehensive imaging-based review with pathologic correlation

Cited by 30 publications

References 36 publications

Nasal juvenile angiofibroma: Current perspectives with emphasis on management

Nasal juvenile angiofibroma: Current perspectives with emphasis on management

A Pilot Evaluation of Magnetic Resonance Imaging Characteristics Seen With Primary Soft Tissue Giant Cell Tumor in 2 patients

Inflammatory Myofibroblastic Tumour of the Submandibular Gland

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