2019
DOI: 10.1038/s41559-018-0768-z
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Fibroblasts and alectinib switch the evolutionary games played by non-small cell lung cancer

Abstract: Heterogeneity in strategies for survival and proliferation among the cells which constitute a tumour is a driving force behind the evolution of resistance to cancer therapy. The rules mapping the tumour’s strategy distribution to the fitness of individual strategies can be represented as an evolutionary game. We develop a game assay to measure effective evolutionary games in co-cultures of non-small cell lung cancer cells which are sensitive and resistant to the anaplastic lymphoma kinase inhibitor Alectinib. … Show more

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Cited by 137 publications
(202 citation statements)
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“…Bacevic et al [12] make similar observations for CDKi resistant cells and a number of further examples can be found in the literature (e.g. [19,20,21,22,23]). In their original work on adaptive therapy, Gatenby et al [2,3] used the cost of resistance to motivate adaptive therapy, and most theoretical studies since have made this assumption [12,13,14].…”
Section: Introductionmentioning
confidence: 64%
“…Bacevic et al [12] make similar observations for CDKi resistant cells and a number of further examples can be found in the literature (e.g. [19,20,21,22,23]). In their original work on adaptive therapy, Gatenby et al [2,3] used the cost of resistance to motivate adaptive therapy, and most theoretical studies since have made this assumption [12,13,14].…”
Section: Introductionmentioning
confidence: 64%
“…(such as the 1mL proposed by Toprak and colleagues) can be specified so that the about the interactions of the different species/types of bacteria [27,28].…”
mentioning
confidence: 99%
“…The present study suggests that intermittent rather than continuous chemotherapy may result in better outcomes in lung cancer. As far as we are aware, such an approach, although investigated in some other solid tumors (Cunningham et al, 2015; Zhang et al, 2017), has never been looked into in lung cancer although, the observations by Kaznatcheev et al (2019) are inferred to support the concept that treatment influences the character of the resistance response in cancer cells (Staňková K, 2019). Such a treatment approach may not cure the patient of the disease, but it would at least result in stable disease that can be managed while sparing the patient of undesirable effects of excessive chemotherapy.…”
Section: Discussionmentioning
confidence: 99%
“…Several studies have applied evolutionary game theory to cancer(Wu et al, 2014; Wu et al, 2015; Zhang et al, 2017; You et al, 2017; Swierniak et al, 2018; Kareva and Karev, 2019; Kaznatcheev et al, 2019; Stanková et al, 2019; West et al, 2019) but as far as we are aware, the adaptive strategies that drug naïve and drug tolerant or resistant NSCLC cancer cells adopt in response to environmental perturbations have not been investigated. A recent paper byKaznatcheev et al (2019) is the only other study where the authors developed an assay to measure effective evolutionary games in co-cultures of isogenic NSCLC cells that are sensitive and resistant to the anaplastic lymphoma kinase inhibitor alectinib. In contrast, in the present study we investigated a broad spectrum chemotherapy (cisplatin) and naturally occurring cisplatin-sensitive and tolerant NSCLC cell lines and developed the PSMSR model to model the experimental observations.…”
mentioning
confidence: 99%