Fibroblasts in Orchestrating Colorectal Tumorigenesis and Progression

Abudukelimu, Subinuer; de Miranda, Noel F.C.C.; Hawinkels, Lukas J.A.C.

doi:10.1016/j.jcmgh.2024.01.013

Cellular and Molecular Gastroenterology and Hepatology

2024

DOI: 10.1016/j.jcmgh.2024.01.013

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Fibroblasts in Orchestrating Colorectal Tumorigenesis and Progression

Subinuer Abudukelimu,

Noel F.C.C. de Miranda,

Lukas J.A.C. Hawinkels

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2024

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Cited by 3 publications

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The role of Hippo/YAP1 in cancer-associated fibroblasts: Literature review and future perspectives

Athavale,

Balch,

Zhang

et al. 2024

Cancer Letters

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The role of Hippo/YAP1 in cancer-associated fibroblasts: Literature review and future perspectives

Athavale,

Balch,

Zhang

et al. 2024

Cancer Letters

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Fibroblast activation protein constitutes a novel target of chimeric antigen receptor T‐cell therapy in solid tumors

Meng,

Hara,

Miura

et al. 2024

Cancer Science

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With recent advances in tumor immunotherapy, chimeric antigen receptor T (CAR‐T) cell therapy has achieved unprecedented success in several hematologic tumors, significantly improving patient prognosis. However, in solid tumors, the efficacy of CAR‐T cell therapy is limited because of high antigen uncertainty and the extremely restrictive tumor microenvironment (TME). This challenge has led to the exploration of new targets, among which fibroblast activation protein (FAP) has gained attention for its relatively stable and specific expression in the TME of various solid tumors, making it a potential new target for CAR‐T cell therapy. This study comprehensively analyzed the biological characteristics of FAP and discussed its potential application in CAR‐T cell therapy, including the theoretical basis, and preclinical and clinical research progress of targeting FAP with CAR‐T cell therapy for solid tumor treatment. The challenges and future optimization directions of this treatment strategy were also explored, providing new perspectives and strategies for CAR‐T cell therapy in solid tumors.

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Unraveling the role of cancer-associated fibroblasts in colorectal cancer

Cui,

Ma,

Gao

et al. 2024

World J Gastrointest Oncol

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Within the intricate milieu of colorectal cancer (CRC) tissues, cancer-associated fibroblasts (CAFs) act as pivotal orchestrators, wielding considerable influence over tumor progression. This review endeavors to dissect the multifaceted functions of CAFs within the realm of CRC, thereby highlighting their indispensability in fostering CRC malignant microenvironment and indicating the development of CAFs-targeted therapeutic interventions. Through a comprehensive synthesis of current knowledge, this review delineates insights into CAFs-mediated modulation of cancer cell proliferation, invasiveness, immune evasion, and neovascularization, elucidating the intricate web of interactions that sustain the pro-tumor metabolism and secretion of multiple factors. Additionally, recognizing the high level of heterogeneity within CAFs is crucial, as they encompass a range of subtypes, including myofibroblastic CAFs, inflammatory CAFs, antigen-presenting CAFs, and vessel-associated CAFs. Innovatively, the symbiotic relationship between CAFs and the intestinal microbiota is explored, shedding light on a novel dimension of CRC pathogenesis. Despite remarkable progress, the orchestrated dynamic functions of CAFs remain incompletely deciphered, underscoring the need for continued research endeavors for therapeutic advancements in CRC management.

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Fibroblasts in Orchestrating Colorectal Tumorigenesis and Progression

Cited by 3 publications

References 50 publications

The role of Hippo/YAP1 in cancer-associated fibroblasts: Literature review and future perspectives

The role of Hippo/YAP1 in cancer-associated fibroblasts: Literature review and future perspectives

Fibroblast activation protein constitutes a novel target of chimeric antigen receptor T‐cell therapy in solid tumors

Unraveling the role of cancer-associated fibroblasts in colorectal cancer

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