2020
DOI: 10.1002/ca.23590
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Fibrocartilaginous metaplasia and neovascularization of the anterior cruciate ligament in patients with osteoarthritis

Abstract: IntroductionThe anterior cruciate ligament (ACL) prevents the anterior translocation and medial rotation of the tibia against the femur. It is typically composed of dense regular connective tissue (DRCT), small amount of loose connective tissue, little vasculature, and few nerve endings. The objective of the current study was to evaluate the details of histological changes in ACLs of patients with clinically diagnosed osteoarthritis (OA).Materials and MethodsThe ACLs of six patients undergoing total knee repla… Show more

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Cited by 7 publications
(4 citation statements)
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“…Stem cells capable of developing into adipocytes, chondrocytes, and osteocytes have been found within human ligaments (Im & Kim, 2020) and the formation of fibrocartilage-like tissue within the anterior cruciate ligament has been observed (Komro et al, 2020). seen in a case of CCJ described by Lewis (1959).…”
Section: Etiologymentioning
confidence: 98%
See 1 more Smart Citation
“…Stem cells capable of developing into adipocytes, chondrocytes, and osteocytes have been found within human ligaments (Im & Kim, 2020) and the formation of fibrocartilage-like tissue within the anterior cruciate ligament has been observed (Komro et al, 2020). seen in a case of CCJ described by Lewis (1959).…”
Section: Etiologymentioning
confidence: 98%
“…Metaplasia has also been proposed as the etiology of the CCJ. Stem cells capable of developing into adipocytes, chondrocytes, and osteocytes have been found within human ligaments (Im & Kim, 2020) and the formation of fibrocartilage‐like tissue within the anterior cruciate ligament has been observed (Komro et al, 2020). Over 130 years ago, Lane (1888) and Anderson (1891) noted that during shoulder extension, when the root of the coracoid process makes contact with the clavicle, the conoid part of the coracoclavicular ligament relaxes and the trapezoid part is compressed.…”
Section: Etiologymentioning
confidence: 99%
“…When considering the biology of the anterior cruciate ligament (ACL) on its own, prior literature has described changes that occur to the histology in both acute and long-term timelines. 12 Native and graft tissues can experience microvascular changes and overall connective tissue structural remodeling called ligamentization" that typically occurs around 6 months but may not finalize until up to 18 months following surgery. 13,14 When performing an ACLR, surgeons have the option of utilizing an autograft or an allograft.…”
Section: Accepted Manuscriptmentioning
confidence: 99%
“…Out of the 14 studies on ligaments, 12 studies focussed on ACL and/or PCL of the knee [33][34][35][36][37][38][39][40][41][42][43][44], and two studies looked at ligaments in the thumb, one covering the palmar beak ligament and one covering volar anterior oblique (AOL) and dorsoradial (DRL) ligaments [45,46]. Studies mostly focussed on collagen fibre organisation, which generally decreased in OA compared to control [38,39,41].…”
Section: Ligaments In Human Oamentioning
confidence: 99%