Fibrocystic disease of pancreas and Crohn's disease.

O’Connor, J. Barry; Lawson, J. T.

doi:10.1136/bmj.4.5840.610

Cited by 13 publications

(6 citation statements)

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“…The combination of CF and Crohn's disease has been reported previously [1][2][3][4][5][6][7][8][9][10]. However, the uniqueness of this case is the fact that the presenting feature of Crohn's disease was masked as abdominal wall cellulitis localized at the right lumbar region.…”

Section: Discussionmentioning

confidence: 56%

Soft tissue inflammation: Presenting feature of Crohn's disease in a cystic fibrosis adolescent

Panagopoulou

Fotoulaki

Tsitouridis

et al. 2007

Journal of Cystic Fibrosis

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We report Crohn's disease in an adolescent with cystic fibrosis (CF). The patient suffered from recurrent abdominal symptoms, which were attributed to distal intestinal obstruction syndrome (DIOS) until a soft tissue inflammation at the right lumbar region and iliac crest revealed an enterosubcutaneous fistula. The diagnosis of Crohn's disease was confirmed on the basis of radiological, endoscopic and histological findings.

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Section: Discussionmentioning

confidence: 56%

Soft tissue inflammation: Presenting feature of Crohn's disease in a cystic fibrosis adolescent

Panagopoulou

Fotoulaki

Tsitouridis

et al. 2007

Journal of Cystic Fibrosis

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“…The concurrence of CF and CD was first reported in a 7-y-old girl in 1972 [1]. Since that time, additional cases reports have emerged, followed by individual reports and small case series from Germany, the United States, Israel, the United Kingdom, and Australia [2,4–11].…”

Section: Discussionmentioning

confidence: 99%

“…Cystic fibrosis (CF) and Crohn's disease (CD) were first described in the same patient in 1972 [1]. Subsequent reports and a national survey in the United States revealed that the incidence of CD in patients with CF is significantly increased over that of the general population [2] Giant inflammatory polyposis (GIP) is a rare manifestation of idiopathic inflammatory bowel disease (IBD).…”

Section: Introductionmentioning

confidence: 99%

Giant Inflammatory Polyposis Coli as a Manifestation of Crohn's Disease in Patients with Coexistent Cystic Fibrosis

et al. 2006

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Crohn's disease (CD) arising in children with cystic fibrosis (CF) is well recognized. Indeed, reports suggest that CD is significantly more common in patients with CF than in the general population. Giant inflammatory polyposis is a rare manifestation of idiopathic inflammatory bowel disease and may complicate both ulcerative colitis and CD. Giant inflammatory polyposis has not been specifically reported in patients with coexistent CF and CD. Herein, we report the occurrence of giant inflammatory polyposis in 2 boys attending a tertiary care hospital, with an established diagnosis of CF who subsequently developed CD. Both boys required surgical treatment for CD. In addition to classical features of CD, both colonic resection specimens showed giant inflammatory polyposis. The appearances were modified by the presence of a layer of thick mucus. It is suggested that the coexistence of CF in patients with CD may predispose to the development of giant inflammatory polyposis. In addition to contributing to their development, it also appears that there is a propensity for CF to alter the morphological appearance of giant inflammatory polyposis. This may lead to diagnostic confusion when examining endoscopic biopsies.

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“…Thus far, three publications have dealt with the simultaneous occurrence of CF and CD (10-12). In the girl described by O'Connor and Lawson (10), CF was diagnosed by the age of I year. Rectal bleeding, diarrhea, and an anal fistula resistant to therapy were the presenting symptoms of CD by the age of9 years .…”

Section: Discussionmentioning

confidence: 99%